NMT1, N-myristoyltransferase 1

NMT1, N-myristoyltransferase 1

• Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]

• Gene Synonyms (NMT, glycylpeptide N-tetradecanoyltransferase 1, alternative, short form NMT-S, long form, NMT-L, myristoyl-CoA:protein N-myristoyltransferase 1, type I N-myristoyltransferase,)
• NCBI Gene ID: 4836
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P30419
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

N-myristoyltransferase 1 interacts with:

• Abelson helper integration site 1
  acyl-CoA binding domain containing 6
  ADP ribosylation factor like GTPase 5A
  angiopoietin like 4
  angiopoietin like 7
  anterior gradient 2, protein disulphide isomerase family member
  apoptosis inducing factor mitochondria associated 3
  ariadne RBR E3 ubiquitin protein ligase 1
  BAG cochaperone 4
  BICD cargo adaptor 2
  bromodomain containing 7
  calcium binding protein 1
  calcium binding protein 2
  cell division cycle associated 3
  centrosomal protein 19
  centrosomal protein 89
  coiled-coil domain containing 77
  DIMT1 rRNA methyltransferase and ribosome maturation factor
  DnaJ heat shock protein family (Hsp40) member C13
  elongation factor Tu GTP binding domain containing 2
  enhancer of mRNA decapping 4
  EP300 interacting inhibitor of differentiation 3
  erythroid differentiation regulatory factor 1
  eukaryotic translation initiation factor 2B subunit beta
  eukaryotic translation initiation factor 2B subunit gamma
  eukaryotic translation initiation factor 3, subunit A
  ezrin
  Fas binding factor 1
  F-box and WD repeat domain containing 7
  F-box protein 17
  FYN binding protein 2
  G protein-coupled receptor class C group 5 member C
  glutaminyl-tRNA synthetase 1
  insulin like growth factor 2 mRNA binding protein 3
  interferon regulatory factor 2 binding protein 1
  LRAT domain containing 2
  MARCKS like 1
  MTOR associated protein, eak-7 homolog
  negative elongation factor complex member B
  neuronal calcium sensor 1
  neurotrophic receptor tyrosine kinase 1
  nitric oxide synthase 3
  NOP56 ribonucleoprotein
  nuclear RNA export factor 1
  outer dense fiber of sperm tails 3 like 2
  phosphatidylinositol specific phospholipase C X domain containing 1
  programmed cell death 6
  proliferation-associated 2G4
  protein kinase cAMP-activated catalytic subunit alpha
  raftlin family member 2
  replication factor C subunit 4
  ribosomal protein L19
  ribosomal protein L23a
  ribosomal protein L35
  ribosomal protein L38
  ribosome binding protein 1
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA polymerase I and III subunit C
  RNA transcription, translation and transport factor
  RP2 activator of ARL3 GTPase
  SERPINE1 mRNA binding protein 1
  sodium channel and clathrin linker 1
  SRC proto-oncogene, non-receptor tyrosine kinase
  STIL centriolar assembly protein
  suppressor of cytokine signaling 6
  transforming growth factor beta 1
  tubulin folding cofactor E
  tumor protein p53
  ubiquitin specific peptidase 14
  valosin containing protein
  vimentin
  vir like m6A methyltransferase associated
  WD repeat domain 61
  Y-box binding protein 1
  Y-box binding protein 3
  zinc and ring finger 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.