YBX1, Y-box binding protein 1

YBX1, Y-box binding protein 1

• This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015]

• Gene Synonyms (BP-8, CBF-A, CSDA2, CSDB, DBPB, EFI-A, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1, Y-box-binding protein 1, CCAAT-binding transcription factor I subunit A, DNA-binding protein B, Y-box transcription factor, enhancer factor I subunit A, major histocompatibility complex, class II, Y box-binding protein I, nuclease-sensitive element-binding protein 1,)
• NCBI Gene ID: 4904
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P67809
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Y-box binding protein 1 interacts with:

• 2'-5'-oligoadenylate synthetase like
  AAR2 splicing factor
  Aly/REF export factor
  ankyrin repeat domain 2
  anterior gradient 2, protein disulphide isomerase family member
  apoptosis inhibitor 5
  argonaute RISC catalytic component 2
  argonaute RISC component 4
  ariadne RBR E3 ubiquitin protein ligase 2
  aurora kinase A
  autophagy related 16 like 1
  BAG cochaperone 6
  basic helix-loop-helix family member a15
  bromodomain containing 7
  BUB3 mitotic checkpoint protein
  cap methyltransferase 1
  CCCTC-binding factor
  chromobox 1
  chromobox 6
  chromobox 8
  coiled-coil domain containing 8
  complement component 1, q subcomponent binding protein
  COP9 signalosome subunit 5
  cullin 1
  cullin 2
  cullin 3
  cullin 4B
  cullin 7
  cullin associated and neddylation dissociated 1
  cytochrome c oxidase subunit 5A
  DDB1 and CUL4 associated factor 4 like 2
  developmental pluripotency-associated 3
  DIMT1 rRNA methyltransferase and ribosome maturation factor
  elongation factor Tu GTP binding domain containing 2
  eukaryotic translation initiation factor 2B subunit beta
  eukaryotic translation initiation factor 3 subunit I
  eukaryotic translation initiation factor 3 subunit K
  eukaryotic translation initiation factor 4A3
  exosome component 9
  exportin 1
  Fas associated factor 1
  F-box and WD repeat domain containing 11
  F-box and WD repeat domain containing 7
  F-box protein 33
  F-box protein 6
  fermitin family member 2
  flotillin 1
  G3BP stress granule assembly factor 1
  GDNF inducible zinc finger protein 1
  GRB10 interacting GYF protein 2
  H2A clustered histone 4
  H4 clustered histone 1
  HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
  hes related family bHLH transcription factor with YRPW motif 1
  HEXIM P-TEFb complex subunit 1
  hyaluronan binding protein 4
  immunoglobulin superfamily member 8
  influenza virus NS1A binding protein
  integrin alpha FG-GAP repeat containing 1
  IQ motif containing B1
  IQ motif containing GTPase activating protein 1
  junctional adhesion molecule 2
  KH RNA binding domain containing, signal transduction associated 2
  kinase suppressor of ras 1
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat kinase 2
  LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
  maelstrom spermatogenic transposon silencer
  major vault protein
  matrin 3
  metadherin
  methylphosphate capping enzyme
  methyltransferase like 14
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 13
  mono-ADP ribosylhydrolase 1
  Mtr4 exosome RNA helicase
  negative elongation factor complex member B
  neurotrophic receptor tyrosine kinase 1
  NOP53 ribosome biogenesis factor
  NOP56 ribonucleoprotein
  nuclear receptor subfamily 2 group C member 2
  nucleolus and neural progenitor protein
  obscurin like cytoskeletal adaptor 1
  OTU deubiquitinase 3
  PAX interacting protein 1
  PHD finger protein 5A
  phosphoinositide-3-kinase regulatory subunit 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  poly(A) specific ribonuclease subunit PAN2
  poly(rC) binding protein 1
  poly(rC) binding protein 2
  polypyrimidine tract binding protein 1
  POU class 5 homeobox 1
  pre-mRNA processing factor 40 homolog A
  pre-mRNA processing factor 8
  prohibitin
  proliferating cell nuclear antigen
  proliferation-associated 2G4
  proteasome 20S subunit alpha 2
  proteasome 20S subunit alpha 4
  proteasome 20S subunit beta 2
  proteasome 20S subunit beta 4
  proteasome 20S subunit beta 5
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 4
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 1 catalytic subunit gamma
  PTEN induced kinase 1
  purine rich element binding protein A
  RAD21 cohesin complex component
  RB binding protein 6, ubiquitin ligase
  RE1 silencing transcription factor
  RecQ like helicase 4
  ribosomal protein L23a
  ribosomal protein L6
  ribosomal protein S2
  ribosomal protein S6 kinase A1
  ribosomal protein S6 kinase A3
  ribosomal protein S6 kinase B2
  ribosome biogenesis regulator 1 homolog
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 2
  ring finger protein 31
  ring finger protein 4
  ring-box 1
  RIO kinase 1
  RNA polymerase II associated protein 2
  serine and arginine rich splicing factor 9
  serine/arginine repetitive matrix 2
  signal recognition particle 72
  single stranded DNA binding protein 1
  sirtuin 1
  SMAD specific E3 ubiquitin protein ligase 1
  SMAD specific E3 ubiquitin protein ligase 2
  small nuclear ribonucleoprotein D1 polypeptide
  small nuclear ribonucleoprotein D2 polypeptide
  small nuclear ribonucleoprotein polypeptide A'
  small nuclear ribonucleoprotein U1 subunit 70
  small nuclear ribonucleoprotein U5 subunit 200
  SMU1 DNA replication regulator and spliceosomal factor
  snail family transcriptional repressor 1
  solute carrier family 6 member 4
  sortilin 1
  spindle apparatus coiled-coil protein 1
  spliceosome associated factor 3, U4/U6 recycling protein
  splicing factor 3a subunit 2
  splicing factor 3b subunit 2
  splicing factor 3b subunit 3
  splicing regulatory glutamic acid and lysine rich protein 1
  SprT-like N-terminal domain
  SRSF protein kinase 2
  SRY-box transcription factor 2
  staufen double-stranded RNA binding protein 1
  structural maintenance of chromosomes 2
  surfeit 2
  SUZ12 polycomb repressive complex 2 subunit
  synaptotagmin binding cytoplasmic RNA interacting protein
  THUMP domain containing 1
  thymopoietin
  thyroid hormone receptor interactor 4
  TNF receptor associated factor 6
  TNFAIP3 interacting protein 2
  transcription factor AP-2 alpha
  transcription factor CP2
  tripartite motif containing 25
  tubulin alpha 4a
  tubulin beta class I
  tumor protein p53
  tumor susceptibility 101
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin associated protein 2 like
  ubiquitin conjugating enzyme E2 A
  ubiquitin specific peptidase 10
  unk zinc finger
  valosin containing protein
  VAMP associated protein B and C
  vascular endothelial growth factor A
  vir like m6A methyltransferase associated
  VPS37B subunit of ESCRT-I
  WD repeat domain 76
  Y-box binding protein 1
  Yes1 associated transcriptional regulator
  YY1 associated factor 2
  zinc finger CCCH-type containing, antiviral 1
  zinc finger CCHC-type and RNA binding motif containing 1
  zinc finger protein 324B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.