PKP2, plakophilin 2

PKP2, plakophilin 2

• This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]

• Gene Synonyms (plakophilin-2, ARVD9,)
• NCBI Gene ID: 5318
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q99959
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

plakophilin 2 interacts with:

• A-kinase anchoring protein 9
  armadillo repeat containing 8
  calcium/calmodulin dependent serine protein kinase
  caspase recruitment domain family member 9
  centrosomal protein 250
  coiled-coil alpha-helical rod protein 1
  coiled-coil domain containing 120
  coiled-coil domain containing 125
  cullin 3
  developmental pluripotency-associated 3
  DMRT like family B with proline rich C-terminal 1
  drosha ribonuclease III
  egl-9 family hypoxia inducible factor 3
  embryonic ectoderm development
  G2 and S-phase expressed 1
  G3BP stress granule assembly factor 1
  GRIP1 associated protein 1
  GTF2I repeat domain containing 1
  hepatitis A virus cellular receptor 2
  hook microtubule tethering protein 2
  kelch like family member 40
  kinesin light chain 4
  leucine rich repeat containing 4C
  lysophosphatidic acid receptor 6
  mago homolog B, exon junction complex subunit
  matrin 3
  microtubule associated scaffold protein 2
  microtubule associated serine/threonine kinase 3
  MINDY lysine 48 deubiquitinase 3
  NCK interacting protein with SH3 domain
  N-terminal glutamine amidase 1
  nudE neurodevelopment protein 1 like 1
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  plakophilin 2
  pleckstrin homology and RhoGEF domain containing G4
  pleckstrin homology domain containing A4
  progesterone immunomodulatory binding factor 1
  prostaglandin E receptor 3
  protocadherin gamma subfamily B, 1
  PTEN induced kinase 1
  rabaptin, RAB GTPase binding effector protein 1
  required for meiotic nuclear division 5 homolog A
  rhophilin associated tail protein 1
  ring finger and CCCH-type domains 2
  ring finger protein 2
  ring finger protein 31
  RNA binding motif protein 5
  RNA polymerase III subunit A
  RPGRIP1 like
  SEC16 homolog A, endoplasmic reticulum export factor
  Sec24 related gene family, member C (S. cerevisiae)
  small nuclear ribonucleoprotein U1 subunit 70
  solute carrier family 14 member 2
  spectrin alpha, erythrocytic 1
  tachykinin receptor 1
  tektin 4
  TNF receptor superfamily member 19
  transmembrane protein 17
  transmembrane protein 52B
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  USO1 vesicle docking factor
  vir like m6A methyltransferase associated
  WW domain containing E3 ubiquitin protein ligase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.