PRPF18, pre-mRNA processing factor 18

PRPF18, pre-mRNA processing factor 18

• Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to the yeast splicing factor Prp18. [provided by RefSeq, Jul 2008]

• Gene Synonyms (pre-mRNA-splicing factor 18, PRP18 homolog, PRP18 pre-mRNA processing factor 18 homolog, PRP18 pre-mRNA processing factor 18 homolog(PRPF18), PRP18, hPrp18,)
• NCBI Gene ID: 8559
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q99633
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pre-mRNA processing factor 18 interacts with:

• activating signal cointegrator 1 complex subunit 2
  angiomotin like 2
  angiotensin II receptor associated protein
  BICD cargo adaptor 2
  brain enriched guanylate kinase associated
  cactin, spliceosome C complex subunit
  calcium binding and coiled-coil domain 2
  calcium dependent secretion activator
  caspase recruitment domain family member 10
  caspase recruitment domain family member 9
  centrosomal protein 70
  chibby family member 2
  coiled-coil domain containing 102B
  coiled-coil domain containing 136
  coiled-coil domain containing 150
  coiled-coil domain containing 57
  cysteine and serine rich nuclear protein 1
  damage specific DNA binding protein 1
  ecotropic viral integration site 5 like
  EF-hand domain containing 2
  fermitin family member 3
  fibronectin type III and SPRY domain containing 2
  GC-rich promoter binding protein 1
  golgin A6 family like 9
  GRIP and coiled-coil domain containing 1
  GRIP1 associated protein 1
  heat shock transcription factor 2 binding protein
  homeobox and leucine zipper encoding
  homeobox containing 1
  hook microtubule tethering protein 2
  IKAROS family zinc finger 1
  keratin 39
  keratin 40
  KN motif and ankyrin repeat domains 2
  LDOC1 regulator of NFKB signaling
  leucine zipper tumor suppressor 1
  leucine zipper tumor suppressor 2
  LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
  microtubule associated scaffold protein 2
  mitotic spindle organizing protein 1
  NIMA (never in mitosis gene a)-related expressed kinase 2
  ninein like
  N-terminal EF-hand calcium binding protein 2
  nucleus accumbens associated 1
  NUT family member 2F
  NUT midline carcinoma family member 1
  oxysterol binding protein like 3
  peptidylprolyl isomerase H
  pleckstrin homology and RhoGEF domain containing G4
  PNMA family member 1
  potassium channel tetramerization domain containing 7
  pre-mRNA processing factor 18
  progesterone immunomodulatory binding factor 1
  protein interacting with PRKCA 1
  RAD50 interactor 1
  ras homolog family member U
  schwannomin interacting protein 1
  sprouty related EVH1 domain containing 1
  syntaxin 11
  translin associated factor X interacting protein 1
  tripartite motif containing 54
  UBX domain protein 11
  zinc finger protein 526
  zinc finger protein 639
  zinc finger RANBP2-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.