SART3, spliceosome associated factor 3, U4/U6 recycling protein

SART3, spliceosome associated factor 3, U4/U6 recycling protein

• The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. [provided by RefSeq, Jul 2008]

• Gene Synonyms (squamous cell carcinoma antigen recognized by T-cells 3, HIV-1 Tat-interacting protein of 110kDa, PRP24 homolog, SART-3, hSART-3, p110 nuclear RNA-binding protein, squamous cell carcinoma antigen recognized by T cells 3, tat-interacting protein of 110 kDa, DSAP1, P100, RP11-13G14, TIP110, p110, p110(nrb),)
• NCBI Gene ID: 9733
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15020
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

spliceosome associated factor 3, U4/U6 recycling protein interacts with:

• acyl-CoA dehydrogenase family member 11
  agmatinase
  Aly/REF export factor
  angiomotin
  ariadne RBR E3 ubiquitin protein ligase 2
  BCL2 associated transcription factor 1
  biogenesis of ribosomes BRX1
  CDKN2A interacting protein
  centromere protein U
  centrosomal AT-AC splicing factor
  cilia and flagella associated protein 20
  cms1 ribosomal small subunit homolog
  COP9 signalosome subunit 5
  cullin associated and neddylation dissociated 1
  DEAD-box helicase 24
  DEAD-box helicase 31
  DEAD-box helicase 47
  decapping enzyme, scavenger
  DExH-box helicase 30
  DExH-box helicase 57
  DnaJ heat shock protein family (Hsp40) member C9
  ecdysoneless cell cycle regulator
  FCF1 rRNA-processing protein
  forkhead box Q1
  FtsJ RNA 2'-O-methyltransferase 3
  GTP binding protein 4
  heterochromatin protein 1 binding protein 3
  HEXIM P-TEFb complex subunit 1
  immunoglobulin superfamily member 8
  integrin alpha FG-GAP repeat containing 1
  karyopherin (importin) alpha 2
  La ribonucleoprotein 1, translational regulator
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich pentatricopeptide repeat containing
  LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM8 homolog, U6 small nuclear RNA associated
  methylphosphate capping enzyme
  M-phase phosphoprotein 10
  multiple EGF like domains 10
  NSA2 ribosome biogenesis factor
  nuclear receptor binding protein 1
  nucleolar complex associated 4 homolog
  nucleolar protein 12
  nucleolus and neural progenitor protein
  nucleoporin 160
  nucleoporin 50
  Obg like ATPase 1
  PALM2 and AKAP2 fusion
  peptidylprolyl isomerase H
  POP1 homolog, ribonuclease P/MRP subunit
  POP7 homolog, ribonuclease P/MRP subunit
  PPAN-P2RY11 readthrough
  pre-mRNA processing factor 3
  pre-mRNA processing factor 31
  pre-mRNA processing factor 8
  proteasome activator subunit 4
  pyrin and HIN domain family member 1
  RAD18 E3 ubiquitin protein ligase
  ribosomal protein L13a
  ribosomal protein L26 like 1
  ribosomal protein L7 like 1
  ribosomal RNA processing 12 homolog
  ribosomal RNA processing 15 homolog
  ribosomal RNA processing 1B
  ribosome production factor 1 homolog
  ribosome production factor 2 homolog
  ring finger and CCCH-type domains 1
  ring finger protein 126
  RIO kinase 1
  RNA binding motif protein 28
  RNA binding motif single stranded interacting protein 3
  RNA binding protein with serine rich domain 1
  RUN and FYVE domain containing 1
  S1 RNA binding domain 1
  sirtuin 6
  sirtuin 7
  SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5)
  spliceosome associated factor 3, U4/U6 recycling protein
  splicing factor 3b subunit 1
  SPT2 chromatin protein domain containing 1
  target of EGR1, exonuclease
  terminal uridylyl transferase 1, U6 snRNA-specific
  thioredoxin interacting protein
  thyroid hormone receptor associated protein 3
  TNFAIP3 interacting protein 2
  tripartite motif containing 28
  ubiquitin protein ligase E3 component n-recognin 4
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 39
  vir like m6A methyltransferase associated
  WW domain containing E3 ubiquitin protein ligase 2
  zinc finger and SCAN domain containing 25
  zinc finger CCCH-type and G-patch domain containing
  zinc finger protein 169
  zinc finger protein 48
  zinc finger protein 574
  zinc finger protein 589
  zinc finger protein 620
  zinc finger protein 71
  zinc finger protein 746
  zinc finger protein 845

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.