HERC2, HECT and RLD domain containing E3 ubiquitin protein ligase 2

HERC2, HECT and RLD domain containing E3 ubiquitin protein ligase 2

• This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]

• Gene Synonyms (E3 ubiquitin-protein ligase HERC2, HECT-type E3 ubiquitin transferase HERC2, hect domain and RCC1-like domain-containing protein 2, hect domain and RLD 2, probable E3 ubiquitin-protein ligase HERC2, D15F37S1, MRT38, SHEP1, jdf2, p528,)
• NCBI Gene ID: 8924
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A8KAQ8
  UNIPROT ID#>>O95714
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

HECT and RLD domain containing E3 ubiquitin protein ligase 2 interacts with:

• adaptor related protein complex 3 subunit delta 1
  adaptor related protein complex 3 subunit sigma 2
  A-kinase anchoring protein 9
  ankyrin repeat domain 26
  aquarius intron-binding spliceosomal factor
  ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
  arginine and glutamate rich 1
  assembly factor for spindle microtubules
  ATR interacting protein
  aurora kinase B
  baculoviral IAP repeat containing 6
  BICD cargo adaptor 2
  BUB3 mitotic checkpoint protein
  calcium homeostasis endoplasmic reticulum protein
  centriolar coiled-coil protein 110
  centrosomal protein 104
  centrosomal protein 135
  centrosomal protein 162
  centrosomal protein 170
  centrosomal protein 170
  centrosomal protein 250
  centrosomal protein 290
  charged multivesicular body protein 4B
  chromobox 2
  cilia and flagella associated protein 20
  claspin
  coiled-coil domain containing 136
  coiled-coil domain containing 151
  coiled-coil domain containing 186
  coiled-coil domain containing 22
  coiled-coil domain containing 65
  coiled-coil domain containing 8
  coiled-coil domain containing 88A
  COPI coat complex subunit beta 2
  COPI coat complex subunit epsilon
  COPI coat complex subunit gamma 1
  COPI coat complex subunit gamma 2
  COPI coat complex subunit zeta 1
  cyclin dependent kinase 12
  cyclin L1
  DEAD-box helicase 41
  DEAD-box helicase 46
  DExD-box helicase 39A
  DnaJ heat shock protein family (Hsp40) member B5
  dpy-30 histone methyltransferase complex regulatory subunit
  drebrin like
  dual specificity phosphatase 26
  EH domain containing 4
  enoyl-CoA delta isomerase 2
  ENY2 transcription and export complex 2 subunit
  ER lipid raft associated 2
  essential meiotic structure-specific endonuclease 1
  ETAA1 activator of ATR kinase
  eukaryotic translation elongation factor 1 alpha 1
  eukaryotic translation initiation factor 3 subunit K
  eukaryotic translation initiation factor 3 subunit L
  eukaryotic translation initiation factor 3 subunit M
  eukaryotic translation initiation factor 4A3
  eukaryotic translation initiation factor 5B
  exonuclease 3'-5' domain containing 2
  family with sequence similarity 83 member H
  family with sequence similarity 98 member A
  FAST kinase domains 5
  F-box and leucine rich repeat protein 5
  F-box and WD repeat domain containing 7
  FERM, ARH/RhoGEF and pleckstrin domain protein 2
  fibronectin type III domain containing 3A
  formin homology 2 domain containing 3
  G protein subunit alpha 13
  G2 and S-phase expressed 1
  GAR1 ribonucleoprotein
  glyoxylate reductase 1 homolog
  GRIP and coiled-coil domain containing 2
  guided entry of tail-anchored proteins factor 4
  H3.5 histone
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
  HIG1 hypoxia inducible domain family member 1A
  histocompatibility minor 13
  hook microtubule tethering protein 1
  HPS3 biogenesis of lysosomal organelles complex 2 subunit 1
  HPS5 biogenesis of lysosomal organelles complex 2 subunit 2
  hydroxysteroid 17-beta dehydrogenase 12
  hydroxysteroid dehydrogenase like 2
  importin 11
  kelch domain containing 4
  keratin 80
  kinesin family member 15
  kinesin family member 19A
  kinesin family member 20A
  lactamase beta
  lamin B2
  leucine rich repeat kinase 2
  LUC7 like
  LUC7 like 2, pre-mRNA splicing factor
  LUC7 like 3 pre-mRNA splicing factor
  lysine rich nucleolar protein 1
  mago homolog B, exon junction complex subunit
  malectin
  mannose-P-dolichol utilization defect 1
  MAP7 domain containing 2
  mediator complex subunit 10
  mediator complex subunit 14
  mediator complex subunit 17
  mediator complex subunit 19
  mediator complex subunit 30
  mediator complex subunit 4
  mediator of DNA damage checkpoint 1
  meiosis regulator for oocyte development
  MINDY lysine 48 deubiquitinase 1
  mitochondrial antiviral signaling protein
  MUS81 structure-specific endonuclease subunit
  MUS81 structure-specific endonuclease subunit
  N-acetyltransferase 10
  NCCRP1, F-box associated domain containing
  neuralized E3 ubiquitin protein ligase 4
  NFKB activating protein
  NHL repeat containing 2
  NIMA related kinase 11
  ninein
  NOP10 ribonucleoprotein
  NPR2 like, GATOR1 complex subunit
  nucleoporin 153
  NudC domain containing 2
  obscurin like cytoskeletal adaptor 1
  PAX3 and PAX7 binding protein 1
  pellino E3 ubiquitin protein ligase 1
  peptidylprolyl isomerase G
  phosphatidylserine synthase 1
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 1
  poly(U) binding splicing factor 60
  pre-mRNA processing factor 38B
  pre-mRNA processing factor 40 homolog A
  primase and DNA directed polymerase
  proline rich 14 like
  proline, glutamate and leucine rich protein 1
  proteasome 26S subunit, non-ATPase 14
  protein inhibitor of activated STAT 4
  RAB34, member RAS oncogene family
  rabaptin, RAB GTPase binding effector protein 1
  RecQ mediated genome instability 1
  RecQ mediated genome instability 2
  retention in endoplasmic reticulum sorting receptor 1
  ribosomal protein L35
  RIC8 guanine nucleotide exchange factor A
  ring finger protein 11
  ring finger protein 115
  ring finger protein 166
  ring finger protein 168
  ring finger protein 8
  RING1 and YY1 binding protein
  RNA binding motif protein 25
  RNA binding motif protein 39
  RNA binding protein with serine rich domain 1
  RNA polymerase I subunit F
  RPA1 related single stranded DNA binding protein, X-linked
  SAP domain containing ribonucleoprotein
  sclerostin
  SEC23 interacting protein
  selenoprotein O
  serine and arginine repetitive matrix 1
  serine and arginine rich splicing factor 11
  serine palmitoyltransferase long chain base subunit 2
  serine/threonine kinase 33
  sirtuin 1
  sirtuin 3
  sirtuin 7
  SLIT-ROBO Rho GTPase activating protein 2
  small nuclear ribonucleoprotein U4/U6.U5 subunit 27
  SNAP associated protein
  solute carrier family 27 member 4
  solute carrier family 30 member 9
  sorting nexin 6
  sperm antigen with calponin homology and coiled-coil domains 1 like
  spermatogenic leucine zipper 1
  splicing regulatory glutamic acid and lysine rich protein 1
  SPOUT domain containing methyltransferase 1
  SSX family member 2 interacting protein
  structural maintenance of chromosomes 3
  SUMO specific peptidase 1
  suppressor of glucose, autophagy associated 1
  synthesis of cytochrome C oxidase 2
  TANK binding kinase 1
  tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
  tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
  TATA-box binding protein associated factor 1 like
  TATA-box binding protein associated factor 8
  taxilin gamma
  testis expressed 10
  THO complex 6
  TNFAIP3 interacting protein 2
  TRAF family member associated NFKB activator
  translation machinery associated 16 homolog
  transmembrane protein 33
  tRNA methyltransferase 2 homolog A
  tubulin alpha 1c
  tubulin beta 3 class III
  tuftelin interacting protein 11
  U2 small nuclear RNA auxiliary factor 2
  U2 snRNP associated SURP domain containing
  ubiquitin C-terminal hydrolase L5
  ubiquitin protein ligase E3 component n-recognin 4
  ubiquitin specific peptidase 16
  ubiquitin specific peptidase 19
  ubiquitin specific peptidase 20
  ubiquitin specific peptidase 42
  vir like m6A methyltransferase associated
  WD repeat domain 24
  WD repeat domain 59
  WD repeat domain 62
  WD repeat domain 92
  zinc finger and BTB domain containing 5
  zinc finger CCHC-type containing 17
  zinc finger DHHC-type palmitoyltransferase 17
  zinc finger FYVE-type containing 9
  zinc finger protein 286A
  zinc finger protein 622
  zinc finger RANBP2-type containing 1
  zinc ribbon domain containing 2
  zymogen granule protein 16B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.