SOD1, superoxide dismutase 1

SOD1, superoxide dismutase 1

• The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (superoxide dismutase [Cu-Zn], Cu/Zn superoxide dismutase, SOD, soluble, epididymis secretory protein Li 44, indophenoloxidase A, superoxide dismutase 1, soluble, superoxide dismutase, cystolic, ALS, ALS1, HEL-S-44, IPOA, SOD, STAHP, hSod1, homodimer,)
• NCBI Gene ID: 6647
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P00441
  UNIPROT ID#>>V9HWC9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

superoxide dismutase 1 interacts with:

• 3-hydroxyisobutyrate dehydrogenase
  3-hydroxyisobutyryl-CoA hydrolase
  6-phosphogluconolactonase
  activating signal cointegrator 1 complex subunit 1
  acyl-CoA thioesterase 7
  adaptor related protein complex 3 subunit delta 1
  adenosylhomocysteinase like 1
  adhesion regulating molecule 1
  ADP-ribosylserine hydrolase
  aldo-keto reductase family 1 member A1
  aldo-keto reductase family 1 member B15
  aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
  apolipoprotein L2
  apoptosis inhibitor 5
  BAF nuclear assembly factor 1
  BCL2 like 13
  brain abundant membrane attached signal protein 1
  cell cycle and apoptosis regulator 2
  centromere protein V
  centrosomal protein 55
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  chloride intracellular channel 4
  chromosome 11 open reading frame 54
  claudin 17
  cleavage and polyadenylation specific factor 7
  coiled-coil-helix-coiled-coil-helix domain containing 2
  collectin subfamily member 10
  COPI coat complex subunit gamma 1
  copper chaperone for superoxide dismutase
  copper chaperone for superoxide dismutase
  copper metabolism domain containing 1
  cutA divalent cation tolerance homolog
  cytochrome c oxidase copper chaperone COX17
  DAZ associated protein 1
  destrin, actin depolymerizing factor
  DExD-box helicase 39B
  DnaJ heat shock protein family (Hsp40) member A1
  dynamin 1 like
  dynein light chain Tctex-type 1
  ependymin related 1
  eukaryotic translation initiation factor 3 subunit A
  eukaryotic translation initiation factor 3 subunit D
  eukaryotic translation initiation factor 3 subunit H
  eukaryotic translation initiation factor 3 subunit I
  eukaryotic translation initiation factor 4A3
  exosome component 6
  FA core complex associated protein 20
  far upstream element binding protein 1
  ferredoxin 2
  FKBP prolyl isomerase 7
  glucosamine-6-phosphate deaminase 2
  glucosidase II alpha subunit
  glutathione S-transferase kappa 1
  glutathione S-transferase omega 1
  glyoxalase domain containing 4
  glyoxylate and hydroxypyruvate reductase
  H1.10 linker histone
  H2A clustered histone 4
  heat shock 105kDa/110kDa protein 1
  heat shock protein 1B
  heat shock protein 2
  heat shock protein 4
  heat shock protein 4 like
  heat shock protein 5
  heat shock protein 8
  heat shock protein 90 beta family member 1
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  histidine triad nucleotide binding protein 2
  histone deacetylase 6
  hornerin
  IQ motif containing GTPase activating protein 1
  kinesin light chain 2
  lactamase beta 2
  lactate dehydrogenase A like 6A
  lactate dehydrogenase A like 6B
  lamin B2
  leucyl-tRNA synthetase 1
  MARCKS like 1
  membrane associated ring-CH-type finger 5
  mitochondrial antiviral signaling protein
  mitogen-activated protein kinase kinase kinase kinase 1
  MOB kinase activator 1B
  MYB binding protein 1a
  myotrophin
  neudesin neurotrophic factor
  NFS1 cysteine desulfurase
  NME1-NME2 readthrough
  NOP10 ribonucleoprotein
  NOP2/Sun RNA methyltransferase 2
  nuclear distribution C, dynein complex regulator
  nuclear transport factor 2
  nucleoporin 93
  optineurin
  Parkinsonism associated deglycase
  PEDS1-UBE2V1 readthrough
  peptidylprolyl isomerase A like 4A
  peptidylprolyl isomerase F
  peptidylprolyl isomerase like 3
  peroxiredoxin 2
  peroxiredoxin 4
  peroxiredoxin 5
  peroxiredoxin 6
  PHD finger protein 21A
  phosphatidylinositol transfer protein beta
  pirin
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 4
  programmed cell death 6 interacting protein
  proline rich 12
  proteasome 26S subunit, non-ATPase 14
  protein disulfide isomerase family A member 4
  protein disulfide isomerase family A member 6
  protein O-glucosyltransferase 3
  pyridoxal kinase
  pyruvate dehyrogenase phosphatase catalytic subunit 1
  RAB21, member RAS oncogene family
  RAB9A, member RAS oncogene family
  regucalcin
  ribonucleic acid export 1
  ring finger protein 19A, RBR E3 ubiquitin protein ligase
  RNA binding motif protein 8A
  RNA transcription, translation and transport factor
  RuvB like AAA ATPase 1
  RuvB like AAA ATPase 2
  SCY1 like pseudokinase 2
  sepiapterin reductase
  signal recognition particle 19
  signal sequence receptor subunit 4
  small RNA binding exonuclease protection factor La
  sorbitol dehydrogenase
  sorcin
  spectrin beta, non-erythrocytic 1
  spectrin repeat containing nuclear envelope protein 2
  spindlin 1
  staphylococcal nuclease and tudor domain containing 1
  STIP1 homology and U-box containing protein 1
  STIP1 homology and U-Box containing protein 1
  stress induced phosphoprotein 1
  succinate-CoA ligase GDP/ADP-forming subunit alpha
  succinate-CoA ligase GDP-forming subunit beta
  sulfatase modifying factor 2
  SUMO1 activating enzyme subunit 1
  superoxide dismutase 1
  superoxide dismutase 1, soluble
  superoxide dismutase 2
  syntaxin binding protein 2
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  thioredoxin
  thioredoxin 2
  thioredoxin like 1
  thyroid hormone receptor interactor 4
  TIA1 cytotoxic granule associated RNA binding protein like 1
  TNF receptor associated protein 1
  TNFAIP3 interacting protein 2
  transgelin 2
  transketolase
  transketolase like 2
  translocase of inner mitochondrial membrane 13
  translocated promoter region, nuclear basket protein
  transport and golgi organization 2 homolog
  triosephosphate isomerase 1
  tripartite motif containing 28
  tubulin folding cofactor A
  tumor protein D52
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquitin C
  ubiquitin conjugating enzyme E2 L3
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 N
  ubiquitin conjugating enzyme E2 V1
  ubiquitin C-terminal hydrolase L1
  ubiquitin fold modifier 1
  ubiquitin like modifier activating enzyme 1
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 9 X-linked
  ubiquitin-fold modifier conjugating enzyme 1
  valosin containing protein
  vesicle amine transport 1
  X-ray repair cross complementing 5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.