DDX17, DEAD-box helicase 17

DDX17, DEAD-box helicase 17

• DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species, but not by dsDNA. This protein, and that encoded by DDX5 gene, are more closely related to each other than to any other member of the DEAD box family. This gene can encode multiple isoforms due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) start codon. [provided by RefSeq, Apr 2011]

• Gene Synonyms (P72, RH70, probable ATP-dependent RNA helicase DDX17, DEAD (Asp-Glu-Ala-Asp) box helicase 17, DEAD (Asp-Glu-Ala-Asp) box polypeptide 17, DEAD box protein p72, DEAD box protein p82, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD), RNA-dependent helicase p72,)
• NCBI Gene ID: 10521
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A1W2PQ51
  UNIPROT ID#>>Q92841
  UNIPROT ID#>>Q59F66
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DEAD-box helicase 17 interacts with:

• AAR2 splicing factor
  anterior gradient 2, protein disulphide isomerase family member
  apoptotic chromatin condensation inducer 1
  ataxin 2 like
  bromodomain containing 7
  cap methyltransferase 1
  CCCTC-binding factor
  cell division cycle 37, HSP90 cochaperone
  centrosomal protein 250
  cleavage and polyadenylation specific factor 6
  coiled-coil domain containing 187
  coiled-coil domain containing 8
  coiled-coil domain containing 9
  COP9 signalosome subunit 5
  cullin associated and neddylation dissociated 1
  DEAD-box helicase 17
  developmental pluripotency-associated 3
  DGCR8 microprocessor complex subunit
  Fas associated factor 1
  F-box and WD repeat domain containing 7
  F-box protein 6
  F-box protein 7
  formin binding protein 4
  fused in sarcoma
  heterogeneous nuclear ribonucleoprotein A3
  HEXIM P-TEFb complex subunit 1
  immunoglobulin superfamily member 8
  influenza virus NS1A binding protein
  INO80 complex subunit B
  integrin alpha FG-GAP repeat containing 1
  KH RNA binding domain containing, signal transduction associated 1
  KH RNA binding domain containing, signal transduction associated 2
  Kin17 DNA and RNA binding protein
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat containing G protein-coupled receptor 4
  ligand of numb-protein X 1
  LSM1 homolog, mRNA degradation associated
  methylphosphate capping enzyme
  methyltransferase like 14
  microtubule associated protein 1 light chain 3 alpha
  NGG1 interacting factor 3 like 1
  nitric oxide synthase interacting protein
  obscurin like cytoskeletal adaptor 1
  parvin alpha
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  pre-mRNA processing factor 8
  prolyl 3-hydroxylase 1
  PTEN induced kinase 1
  pyridoxal phosphate binding protein
  replication termination factor 2
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 31
  RIO kinase 1
  RNA binding motif protein 15
  RNA binding protein with serine rich domain 1
  SBDS ribosome maturation factor
  serine and arginine-rich splicing factor 1
  SH3 domain containing kinase binding protein 1
  splicing regulatory glutamic acid and lysine rich protein 1
  SprT-like N-terminal domain
  SUMO specific peptidase 3
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  TAR DNA binding protein
  taxilin alpha
  taxilin gamma
  THO complex 7
  TNFAIP3 interacting protein 2
  tripartite motif containing 3
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin like modifier activating enzyme 5
  WW domain binding protein 11
  WW domain binding protein 2
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  YLP motif containing 1
  zinc finger FYVE-type containing 21
  ZW10 interacting kinetochore protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.