SOAT1, sterol O-acyltransferase 1

SOAT1, sterol O-acyltransferase 1

• The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

• Gene Synonyms (sterol O-acyltransferase 1, acyl-coenzyme A:cholesterol acyltransferase 1, sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1, ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT,)
• NCBI Gene ID: 6646
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P35610
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sterol O-acyltransferase 1 interacts with:

• ADAM metallopeptidase domain 33
  adhesion G protein-coupled receptor G5
  Aly/REF export factor
  apoptosis inducing factor mitochondria associated 1
  ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
  ATP synthase membrane subunit f
  ATPase family AAA domain containing 3A
  ATPase family AAA domain containing 3B
  BAF nuclear assembly factor 1
  bolA family member 2
  bolA family member 2B
  bone morphogenetic protein receptor, type 1A
  carnosine N-methyltransferase 1
  centriolin
  charged multivesicular body protein 4B
  charged multivesicular body protein 4B
  chromatin target of PRMT1
  complement component 1, q subcomponent binding protein
  dermcidin
  EH domain binding protein 1
  ER lipid raft associated 2
  eukaryotic translation elongation factor 1 alpha 1
  eukaryotic translation elongation factor 1 epsilon 1
  EvC ciliary complex subunit 2
  family with sequence similarity 187 member B
  family with sequence similarity 189 member A2
  filaggrin family member 2
  glucosidase II alpha subunit
  glycosylphosphatidylinositol anchor attachment 1
  golgi transport 1B
  H1.10 linker histone
  H4 clustered histone 1
  heat shock protein 90 beta family member 1
  hornerin
  katanin catalytic subunit A1
  kinectin 1
  LIM domain and actin binding 1
  LY6/PLAUR domain containing 6
  MARCKS like 1
  membrane bound O-acyltransferase domain containing 7
  MOB kinase activator 2
  myosin, heavy polypeptide 9, non-muscle
  myotubularin related protein 14
  myotubularin related protein 6
  myotubularin related protein 7
  myotubularin related protein 8
  OTU deubiquitinase with linear linkage specificity like
  PDZ and LIM domain 7
  peptidylprolyl isomerase A like 4A
  peroxiredoxin 3
  peroxiredoxin 6
  phosphatidylinositol glycan anchor biosynthesis class S
  phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
  pleckstrin homology domain containing A4
  popeye domain containing 2
  programmed cell death 6 interacting protein
  protocadherin beta 15
  RAB11A, member RAS oncogene family
  RAB5C, member RAS oncogene family
  RAB7A, member RAS oncogene family
  RBMX like 2
  regulator of microtubule dynamics 3
  reticulon 4 receptor
  ring finger protein 11
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  SCY1 like pseudokinase 2
  Sec24 related gene family, member C (S. cerevisiae)
  semaphorin 7A (John Milton Hagen blood group)
  SERPINE1 mRNA binding protein 1
  sideroflexin 1
  solute carrier family 25 member 13
  spastin
  sphingomyelin phosphodiesterase 3
  staufen double-stranded RNA binding protein 1
  stomatin like 2
  synoviolin 1
  tectonic family member 2
  tectonic family member 3
  telomeric repeat binding factor 1
  tetraspanin 5
  thioredoxin
  TNF receptor associated protein 1
  trans-2,3-enoyl-CoA reductase
  transcription factor 7 like 2
  transketolase
  translocase of outer mitochondrial membrane 22
  transmembrane p24 trafficking protein 2
  transmembrane protein 128
  transmembrane protein 17
  transmembrane protein 216
  transmembrane protein 41B
  transmembrane protein 63B
  transmembrane serine protease 12
  triosephosphate isomerase 1
  tripartite motif containing 25
  tropomyosin 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  UbiA prenyltransferase domain containing 1
  ubiquinol-cytochrome c reductase core protein 1
  ubiquinol-cytochrome c reductase core protein 2
  uroplakin 1A
  vacuole membrane protein 1
  VAMP associated protein A
  vanin 2
  voltage dependent anion channel 1
  voltage dependent anion channel 2
  voltage dependent anion channel 3
  Yip1 domain family member 3
  zinc activated ion channel

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.