HCK, HCK proto-oncogene, Src family tyrosine kinase

HCK, HCK proto-oncogene, Src family tyrosine kinase

• The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

• Gene Synonyms (tyrosine-protein kinase HCK, hematopoietic cell kinase, hemopoietic cell kinase, p59-HCK/p60-HCK, JTK9, p59Hck, p61Hck,)
• NCBI Gene ID: 3055
• Species: Homo sapiens (Human)
• UNIPROT ID#>>F6SF04
  UNIPROT ID#>>P08631
  UNIPROT ID#>>A8K4G3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

HCK proto-oncogene, Src family tyrosine kinase interacts with:

• acylglycerol kinase
  ADAM metallopeptidase domain 15
  anterior gradient 2, protein disulphide isomerase family member
  ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
  BCAR1 scaffold protein, Cas family member
  BPI fold containing family A member 1
  cancer/testis antigen 1A
  carbohydrate sulfotransferase 15
  CD2 associated protein
  cell division cycle 37, HSP90 cochaperone
  coiled-coil domain containing 88B
  cysteine rich tail 1
  cytochrome b5 domain containing 2
  docking protein 2
  Enah/Vasp-like
  engulfment and cell motility 1
  fibroblast growth factor receptor substrate 3
  four and a half LIM domains 5
  golgi associated PDZ and coiled-coil motif containing
  HCK proto-oncogene, Src family tyrosine kinase
  heat shock protein 90 alpha family class A member 1
  heat shock transcription factor 2 binding protein
  heterogeneous nuclear ribonucleoprotein K
  HEXIM P-TEFb complex subunit 1
  inhibitor of CDK, cyclin A1 interacting protein 1
  inositol polyphosphate-5-phosphatase D
  interferon regulatory factor 2 binding protein like
  interleukin 6 signal transducer
  keratin 31
  keratin 34
  keratin 35
  keratin 36
  keratin 40
  keratin associated protein 10-7
  keratin associated protein 10-8
  keratin associated protein 10-9
  keratin associated protein 1-1
  keratin associated protein 1-3
  keratin associated protein 3-1
  keratinocyte proline rich protein
  KH RNA binding domain containing, signal transduction associated 1
  KIT proto-oncogene, receptor tyrosine kinase
  KRAS proto-oncogene, GTPase
  La ribonucleoprotein 7, transcriptional regulator
  lamin A/C
  LETM1 domain containing 1
  lymphocyte cytosolic protein 2
  makorin ring finger protein 3
  MDM2 proto-oncogene
  mediator complex subunit 28
  microtubule associated scaffold protein 2
  midkine
  midline 2
  mitogen-activated protein kinase kinase kinase kinase 5
  MYC proto-oncogene, bHLH transcription factor
  myelin basic protein
  NBPF member 19
  neuronal guanine nucleotide exchange factor
  notch 2 N-terminal like A
  oligodendrocyte transcription factor 1
  p21 (RAC1) activated kinase 2
  phenylethanolamine N-methyltransferase
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  phosphoinositide-3-kinase regulatory subunit 1
  phosphoinositide-3-kinase regulatory subunit 2
  phosphoinositide-3-kinase regulatory subunit 3
  phospholipase C gamma 1
  phospholipase C gamma 2
  plasminogen activator, urokinase receptor
  platelet and endothelial cell adhesion molecule 1
  pleckstrin homology and RhoGEF domain containing G4
  PNMA family member 1
  protein tyrosine kinase 2
  RAS p21 protein activator 1
  RAS p21 protein activator 3
  ribosomal protein L10
  RNA binding protein, mRNA processing factor
  RUN and FYVE domain containing 1
  SH2B adaptor protein 2
  SH3 domain binding protein 1
  SH3 domain containing kinase binding protein 1
  signal transducer and activator of transcription 3
  small proline rich protein 2A
  SOS Ras/Rac guanine nucleotide exchange factor 1
  splicing factor 3b subunit 3
  src kinase associated phosphoprotein 2
  SRC proto-oncogene, non-receptor tyrosine kinase
  tektin 4
  TEPSIN adaptor related protein complex 4 accessory protein
  thyroid hormone receptor interactor 6
  TOX high mobility group box family member 2
  transient receptor potential cation channel subfamily V member 4
  tripartite motif containing 27
  tumor protein p73
  tumor susceptibility 101
  tyrosine kinase non receptor 2
  ubiquitin specific peptidase 14
  unc-119 lipid binding chaperone
  vav guanine nucleotide exchange factor 1
  WAS/WASL interacting protein family member 1
  WASP actin nucleation promoting factor
  WD repeat and coiled coil containing
  Wnt family member 2
  zinc finger and SCAN domain containing 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.