SIAH1, siah E3 ubiquitin protein ligase 1

SIAH1, siah E3 ubiquitin protein ligase 1

• This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

• Gene Synonyms (E3 ubiquitin-protein ligase SIAH1, RING-type E3 ubiquitin transferase SIAH1, seven in absentia homolog 1, siah-1a, SIAH1A,)
• NCBI Gene ID: 6477
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8IUQ4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

siah E3 ubiquitin protein ligase 1 interacts with:

• AAR2 splicing factor
  AF4/FMR2 family member 4
  aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
  armadillo repeat containing 9
  axin 1
  axin 2
  BAG cochaperone 3
  BAG cochaperone 4
  calcyclin binding protein
  cell division cycle 23
  cellular communication network factor 4
  coiled-coil domain containing 198
  COP9 signalosome subunit 5
  cyclin dependent kinase 5 regulatory subunit 1
  DEAD-box helicase 41
  developmental pluripotency-associated 3
  DnaJ heat shock protein family (Hsp40) member C15
  dynein axonemal light intermediate chain 1
  elongation factor for RNA polymerase II 2
  eukaryotic translation initiation factor 3 subunit J
  exocyst complex component 3 like 2
  family with sequence similarity 90 member A1
  frizzled class receptor 9
  glutamine rich 1
  glycerophosphodiester phosphodiesterase domain containing 5
  H4 histone 16
  homeodomain interacting protein kinase 1
  homeodomain interacting protein kinase 2
  homeodomain interacting protein kinase 3
  homocysteine inducible ER protein with ubiquitin like domain 1
  hypoxia inducible factor 1 subunit alpha inhibitor
  IQ motif containing N
  junctional sarcoplasmic reticulum protein 1
  katanin catalytic subunit A1 like 1
  KH RNA binding domain containing, signal transduction associated 3
  KIAA0319 like
  KIAA1217
  kinesin family member 1B
  Kruppel like factor 10
  lactamase beta 2
  LanC like 2
  large tumor suppressor kinase 2
  meiosis 1 associated protein
  microtubule associated protein RP/EB family member 3
  mitochondrial translational initiation factor 3
  mitogen-activated protein kinase binding protein 1
  MOB kinase activator 3C
  myeloblastosis oncogene
  nanos C2HC-type zinc finger 2
  nanos C2HC-type zinc finger 3
  negative elongation factor complex member A
  N-terminal glutamine amidase 1
  nucleolar protein 6
  NUMB endocytic adaptor protein
  NUMB like endocytic adaptor protein
  OTU deubiquitinase, ubiquitin aldehyde binding 2
  par-3 family cell polarity regulator
  par-6 family cell polarity regulator beta
  paternally expressed 10
  phospholipase C epsilon 1
  PICALM interacting mitotic regulator
  PIH1 domain containing 1
  poly(U) binding splicing factor 60
  pre-mRNA processing factor 31
  proline rich 20A
  proline rich 20B
  proline rich 20C
  proline rich 20D
  proline rich 20E
  protein inhibitor of activated STAT 1
  protein inhibitor of activated STAT 2
  protein inhibitor of activated STAT 3
  protein tyrosine phosphatase mitochondrial 1
  pumilio RNA binding family member 1
  pumilio RNA binding family member 2
  RAB33A, member RAS oncogene family
  RAB33B, member RAS oncogene family
  RAD51 associated protein 1
  RAD54 like 2
  Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
  ribosomal protein S19 binding protein 1
  ring finger protein, LIM domain interacting
  Scm like with four mbt domains 2
  SH3 domain containing ring finger 1
  siah E3 ubiquitin protein ligase 1
  siah E3 ubiquitin protein ligase 2
  signal transducer and activator of transcription 3
  SLC9A3 regulator 2
  spermatogenesis and centriole associated 1 like
  spermatogenesis associated 4
  synaptophysin
  synaptotagmin 7
  synuclein alpha
  synuclein alpha interacting protein
  TBC1 domain family member 22B
  telomeric repeat binding factor 2
  thioredoxin
  toll interacting protein
  transcription factor Dp-1
  transducin beta like 1 X-linked
  transmembrane protein 43
  tribbles pseudokinase 3
  tripartite motif containing 7
  tripartite motif containing 8
  tubulin alpha 1a
  tubulin alpha 1b
  tubulin alpha 3c
  tubulin alpha 4a
  tubulin alpha 8
  tumor protein p53 binding protein 2
  tyrosine kinase non receptor 2
  ubiquitin conjugating enzyme E2 D1
  ubiquitin conjugating enzyme E2 D2
  ubiquitin conjugating enzyme E2 D3
  ubiquitin conjugating enzyme E2 D4 (putative)
  ubiquitin conjugating enzyme E2 E2
  ubiquitin conjugating enzyme E2 E3
  ubiquitin conjugating enzyme E2 I
  ubiquitin conjugating enzyme E2 L6
  ubiquitin conjugating enzyme E2 N
  ubiquitin conjugating enzyme E2 V2
  ubiquitin specific peptidase 19
  ubiquitously expressed prefoldin like chaperone
  uridine phosphorylase 2
  vav guanine nucleotide exchange factor 1
  Z-DNA binding protein 1
  zinc finger CCHC-type containing 10
  zinc finger CCHC-type containing 13
  zinc finger FYVE-type containing 21
  zinc finger matrin-type 3
  zinc finger protein 148
  zinc finger protein 512B
  zinc finger protein 671
  zyxin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.