PSMB7, proteasome 20S subunit beta 7

PSMB7, proteasome 20S subunit beta 7

• The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Jul 2012]

• Gene Synonyms (proteasome subunit beta type-7, epididymis secretory sperm binding protein, macropain chain Z, multicatalytic endopeptidase complex chain Z, proteasome (prosome, macropain) subunit, beta type, 7, proteasome catalytic subunit 2, proteasome subunit Z, proteasome subunit alpha, proteasome subunit beta 7, proteasome subunit beta2, protein serine kinase c17,)
• NCBI Gene ID: 5695
• Species: Homo sapiens (Human)
• UNIPROT ID#>>E9KL30
  UNIPROT ID#>>Q99436
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteasome 20S subunit beta 7 interacts with:

• adhesion regulating molecule 1
  aurora kinase A
  catenin beta like 1
  cell division cycle 37, HSP90 cochaperone
  chloride intracellular channel 4
  chromobox 8
  chromosome 11 open reading frame 58
  derlin 1
  desumoylating isopeptidase 1
  EMG1 N1-specific pseudouridine methyltransferase
  F-box protein 7
  FKBP prolyl isomerase 8
  glycogen phosphorylase L
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  IQ motif containing B1
  L3MBTL histone methyl-lysine binding protein 1
  LEO1 homolog, Paf1/RNA polymerase II complex component
  limb development membrane protein 1 like
  mitochondrial ribosomal protein L22
  N-alpha-acetyltransferase 25, NatB auxiliary subunit
  NudC domain containing 2
  obscurin like cytoskeletal adaptor 1
  proteasome (prosome, macropain) subunit, beta type 4
  proteasome (prosome, macropain) subunit, beta type 5
  proteasome 20S subunit alpha 8
  proteasome 20S subunit beta 7
  proteasome 20S subunit beta 8
  proteasome 20S subunit beta 9
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 4
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 4
  proteasome 26S subunit, non-ATPase 5
  proteasome 26S subunit, non-ATPase 6
  proteasome 26S subunit, non-ATPase 7
  proteasome 26S subunit, non-ATPase 8
  proteasome activator subunit 1
  proteasome activator subunit 2
  proteasome activator subunit 4
  proteasome assembly chaperone 1
  proteasome assembly chaperone 2
  proteasome assembly chaperone 3
  proteasome inhibitor subunit 1
  proteasome maturation protein
  protein tyrosine phosphatase non-receptor type 2
  pyrin and HIN domain family member 1
  RAD23 homolog A, nucleotide excision repair protein
  RAD23 homolog B, nucleotide excision repair protein
  RecQ like helicase 4
  required for meiotic nuclear division 5 homolog A
  ribonucleic acid export 1
  RNA polymerase I and III subunit C
  S100 calcium binding protein A9
  serpin family A member 10
  S-phase kinase associated protein 1
  synapse associated protein 1
  synoviolin 1
  tripartite motif containing 14
  tripartite motif containing 25
  tropomodulin 3
  ubiquitin C
  ubiquitin conjugating enzyme E2 D1
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 15
  vir like m6A methyltransferase associated
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.