DDX46, DEAD-box helicase 46

DDX46, DEAD-box helicase 46

• This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]

• Gene Synonyms (probable ATP-dependent RNA helicase DDX46, DEAD (Asp-Glu-Ala-Asp) box polypeptide 46, DEAD box protein 46, PRP5 homolog, Prp5-like DEAD-box protein, RNA helicase, PRPF5, Prp5,)
• NCBI Gene ID: 9879
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q7L014
  UNIPROT ID#>>A0A0C4DG89
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DEAD-box helicase 46 interacts with:

• AAR2 splicing factor
  bromodomain containing 7
  CD2 cytoplasmic tail binding protein 2
  DDB1 and CUL4 associated factor 15
  fucose mutarotase
  gem nuclear organelle associated protein 5
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  hes related family bHLH transcription factor with YRPW motif 1
  INO80 complex subunit B
  jumonji domain containing 6, arginine demethylase and lysine hydroxylase
  La ribonucleoprotein 7, transcriptional regulator
  LEO1 homolog, Paf1/RNA polymerase II complex component
  LUC7 like 2, pre-mRNA splicing factor
  mab-21 like 2
  methyltransferase like 14
  microtubule associated scaffold protein 2
  myosin XVIIIA
  obscurin like cytoskeletal adaptor 1
  pleckstrin homology domain containing A4
  pre-mRNA processing factor 40 homolog A
  pre-mRNA processing factor 8
  REST corepressor 1
  reticulon 4
  ring finger and CCCH-type domains 1
  SIN3 transcription regulator family member A
  sirtuin 7
  small integral membrane protein 20
  small nuclear ribonucleoprotein U4/U6.U5 subunit 27
  SNW domain containing 1
  spindle apparatus coiled-coil protein 1
  splicing factor 3a subunit 1
  splicing factor 3a subunit 3
  splicing factor 3a, subunit 1
  thioredoxin interacting protein
  transcription activation suppressor
  ubiquitin protein ligase E3 component n-recognin 4
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.