IMPDH2, inosine monophosphate dehydrogenase 2

IMPDH2, inosine monophosphate dehydrogenase 2

• This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]

• Gene Synonyms (inosine-5'-monophosphate dehydrogenase 2, IMP (inosine 5'-monophosphate) dehydrogenase 2, IMP (inosine monophosphate) dehydrogenase 2, IMP oxireductase 2, IMPD 2, IMPDH 2, epididymis secretory sperm binding protein, inosine 5' phosphate dehydrogenase 2, inosine monophosphate dehydrogenase type II, IMPD2, IMPDH-II,)
• NCBI Gene ID: 3615
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P12268
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

inosine monophosphate dehydrogenase 2 interacts with:

• 3-hydroxyisobutyrate dehydrogenase
  acetyl-CoA acyltransferase 2
  activator of HSP90 ATPase activity 1
  adaptor related protein complex 4 subunit mu 1
  ADP-ribosylserine hydrolase
  anaphase promoting complex subunit 13
  ankyrin repeat domain 9
  anterior gradient 2, protein disulphide isomerase family member
  APAF1 interacting protein
  apoptosis inhibitor 5
  ataxin 3
  autophagy related 16 like 1
  autophagy related 5
  BCAR3 adaptor protein, NSP family member
  bone morphogenetic protein receptor, type 1A
  CD2 associated protein
  cereblon
  charged multivesicular body protein 4B
  ciliogenesis and planar polarity effector 2
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  cullin 3
  cullin 7
  DExD-box helicase 39B
  dynamin 1 like
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  enolase-phosphatase 1
  ER membrane protein complex subunit 2
  FA complementation group I
  Fas associated factor 1
  F-box protein 25
  F-box protein 6
  glomulin, FKBP associated protein
  golgi brefeldin A resistant guanine nucleotide exchange factor 1
  guanine monophosphate synthase
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  histone deacetylase 5
  inhibitor of nuclear factor kappa B kinase subunit epsilon
  inosine monophosphate dehydrogenase 2
  integrator complex subunit 13
  integrin alpha FG-GAP repeat containing 1
  interleukin 1 family member 10
  jun B proto-oncogene
  lactate dehydrogenase A
  limb development membrane protein 1 like
  mediator complex subunit 9
  mediator of DNA damage checkpoint 1
  membrane magnesium transporter 1
  membrane metalloendopeptidase
  methyltransferase like 3
  minichromosome maintenance complex component 2
  mitogen-activated protein kinase 10
  MYC proto-oncogene, bHLH transcription factor
  myosin IC
  NEDD4 E3 ubiquitin protein ligase
  nestin
  neurotrophic receptor tyrosine kinase 1
  NK2 homeobox 1
  NMD3 ribosome export adaptor
  NOP9 nucleolar protein
  nuclear cap binding protein subunit 1
  nuclear receptor subfamily 2 group C member 2
  nucleophosmin 1
  nucleoporin 50
  OFD1 centriole and centriolar satellite protein
  parkin RBR E3 ubiquitin protein ligase
  Parkinsonism associated deglycase
  patched 1
  PCI domain containing 2
  peroxisomal biogenesis factor 14
  phosphoribosyl pyrophosphate amidotransferase
  pleckstrin homology domain containing A4
  poly(rC) binding protein 1
  POU class 6 homeobox 2
  protein inhibitor of activated STAT 4
  protein kinase cAMP-dependent type II regulatory subunit alpha
  pseudouridine synthase like 1
  PTEN induced kinase 1
  PTTG1 regulator of sister chromatid separation, securin
  RecQ like helicase 4
  replication protein A1
  replication protein A2
  replication protein A3
  ribosomal protein L15
  ribosomal protein S6
  ring finger protein 4
  SEC16 homolog A, endoplasmic reticulum export factor
  secreted protein acidic and cysteine rich
  serine/threonine kinase like domain containing 1
  SH3 domain containing kinase binding protein 1
  signal transducer and activator of transcription 3
  sirtuin 6
  sirtuin 7
  small nuclear ribonucleoprotein 13
  small nuclear RNA activating complex polypeptide 1
  small ubiquitin like modifier 4
  SMCR8-C9orf72 complex subunit
  snail family transcriptional repressor 1
  solute carrier family 25 member 44
  sorting nexin 2
  sorting nexin 6
  S-phase kinase associated protein 2
  spindle and kinetochore associated complex subunit 3
  SRY-box transcription factor 2
  staufen double-stranded RNA binding protein 1
  superoxide dismutase 1
  TEPSIN adaptor related protein complex 4 accessory protein
  TNF receptor associated factor 2
  TNFAIP3 interacting protein 2
  transcription factor CP2
  transforming growth factor beta 1
  tripartite motif containing 25
  U2 small nuclear RNA auxiliary factor 2
  ubiquilin 2
  ubiquilin 4
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L3
  ubiquitin like modifier activating enzyme 6
  ubiquitin specific peptidase 14
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  von Hippel-Lindau tumor suppressor
  WW domain containing oxidoreductase
  X-ray repair cross complementing 3
  Yes1 associated transcriptional regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.