NCBP1, nuclear cap binding protein subunit 1

NCBP1, nuclear cap binding protein subunit 1

• The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008]

• Gene Synonyms (CBP80, NCBP, Sto1, nuclear cap-binding protein subunit 1, 80 kDa nuclear cap-binding protein, NCBP 80 kDa subunit, nuclear cap binding protein subunit 1, 80kDa,)
• NCBI Gene ID: 4686
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R179
  UNIPROT ID#>>Q09161
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nuclear cap binding protein subunit 1 interacts with:

• 5'-3' exoribonuclease 2
  adaptor related protein complex 1 subunit mu 1
  Aly/REF export factor
  anterior gradient 2, protein disulphide isomerase family member
  apolipoprotein L2
  arginine and serine rich coiled-coil 1
  autophagy related 16 like 1
  biorientation of chromosomes in cell division 1 like 1
  BRCA1 associated ATM activator 1
  cell division cycle 16
  centrosomal protein 85-like
  ceramide kinase
  COP9 signalosome subunit 5
  cullin 1
  cullin 3
  cullin 5
  cullin associated and neddylation dissociated 1
  DEAD-box helicase 20
  DENN/MADD domain containing 6A
  DExD-box helicase 39B
  DNA polymerase delta interacting protein 3
  ELKS/RAB6-interacting/CAST family member 1
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  eukaryotic translation initiation factor 3 subunit B
  exportin 1
  family with sequence similarity 50 member A
  fermitin family member 3
  G1 to S phase transition 2
  GCN1 activator of EIF2AK4
  gem nuclear organelle associated protein 2
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  influenza virus NS1A binding protein
  integrator complex subunit 5
  kinesin light chain 3
  La ribonucleoprotein 7, transcriptional regulator
  LETM1 domain containing 1
  lin-28 homolog A
  lin-28 homolog B
  LUC7 like
  Ly1 antibody reactive
  major vault protein
  mediator complex subunit 20
  mediator complex subunit 23
  methylphosphate capping enzyme
  methyltransferase like 3
  Mtr4 exosome RNA helicase
  myosin, heavy polypeptide 3, skeletal muscle, embryonic
  N-alpha-acetyltransferase 10, NatA catalytic subunit
  negative elongation factor complex member A
  negative elongation factor complex member B
  negative elongation factor complex member C/D
  negative elongation factor complex member E
  neurotrophic receptor tyrosine kinase 1
  NKAP domain containing 1
  nuclear cap binding protein subunit 1
  nuclear cap binding protein subunit 2
  nuclear cap binding protein subunit 2
  nuclear cap binding subunit 3
  nuclear distribution C, dynein complex regulator
  nuclear factor I C
  nuclear receptor subfamily 2 group C member 2
  nucleolin
  nucleoporin 42
  obscurin like cytoskeletal adaptor 1
  phosphogluconate dehydrogenase
  phosphorylated adaptor for RNA export
  pleckstrin homology domain containing A4
  poly(rC) binding protein 1
  PPARG related coactivator 1
  prohibitin
  proline-serine-threonine phosphatase interacting protein 1
  protein arginine methyltransferase 5
  protein phosphatase 2 scaffold subunit Abeta
  protein phosphatase, Mg2+/Mn2+ dependent 1G
  protein tyrosine phosphatase receptor type A
  pseudouridine synthase 1
  pyrin and HIN domain family member 1
  pyruvate dehydrogenase E1 subunit alpha 1
  RAD18 E3 ubiquitin protein ligase
  RecQ like helicase 4
  regulation of nuclear pre-mRNA domain containing 2
  ribosomal protein S6 kinase B1
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 123
  ring finger protein 2
  ring finger protein 20
  ring finger protein 4
  ring finger protein 40
  RNA binding motif protein 27
  RNA binding motif protein 7
  RuvB like AAA ATPase 1
  SEC23 interacting protein
  serine and arginine rich splicing factor 9
  serine/threonine kinase like domain containing 1
  serpin family E member 2
  serrate, RNA effector molecule
  sirtuin 7
  Smad nuclear interacting protein 1
  small nuclear ribonucleoprotein polypeptide A'
  small nuclear ribonucleoprotein U1 subunit 70
  small nuclear RNA activating complex polypeptide 1
  SNW domain containing 1
  sorting nexin 2
  splicing factor 3a subunit 2
  staufen double-stranded RNA binding protein 1
  stem-loop binding protein
  structural maintenance of chromosomes 1A
  structural maintenance of chromosomes 3
  succinate dehydrogenase complex subunit C
  SUMO specific peptidase 3
  superoxide dismutase 1, soluble
  SUZ12 polycomb repressive complex 2 subunit
  synuclein alpha
  TAR DNA binding protein
  TATA-box binding protein associated factor 15
  tetratricopeptide repeat domain 1
  thioredoxin interacting protein
  THO complex 1
  THO complex 2
  THO complex 3
  THO complex 5
  THO complex 6
  TNFAIP3 interacting protein 2
  TPX2, microtubule-associated
  transcriptional adaptor 2A
  transformation/transcription domain associated protein
  transmembrane p24 trafficking protein 2
  tubulin, gamma 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin like 4A
  unk zinc finger
  UPF1 RNA helicase and ATPase
  UPF3B regulator of nonsense mediated mRNA decay
  USO1 vesicle docking factor
  vesicle amine transport 1
  vir like m6A methyltransferase associated
  zinc finger and SCAN domain containing 26
  zinc finger DHHC-type palmitoyltransferase 17
  zinc finger protein 346
  zinc finger protein 574

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.