LMO2, LIM domain only 2

LMO2, LIM domain only 2

• LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]

• Gene Synonyms (LMO-2, RBTN2, RBTNL1, RHOM2, TTG2, rhombotin-2, LIM domain only protein 2, T-cell translocation gene 2, T-cell translocation protein 2, cysteine-rich protein TTG-2, rhombotin-like 1,)
• NCBI Gene ID: 4005
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P25791
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

LIM domain only 2 interacts with:

• abhydrolase domain containing 8
  abl interactor 2
  ADAMTS like 4
  afadin, adherens junction formation factor
  AHNAK nucleoprotein 2
  aldehyde dehydrogenase 6 family member A1
  aminoacyl tRNA synthetase complex interacting multifunctional protein 2
  angiotensin II receptor associated protein
  armadillo repeat containing 5
  aryl hydrocarbon receptor nuclear translocator 2
  AT-rich interaction domain 5A
  axin 1
  basic leucine zipper nuclear factor 1
  BCAS2 pre-mRNA processing factor
  brain expressed X-linked 2
  BTG3 associated nuclear protein
  calcium binding and coiled-coil domain 2
  CCZ1 homolog, vacuolar protein trafficking and biogenesis associated
  checkpoint kinase 2
  chibby family member 2
  chromosome 1 open reading frame 109
  chromosome 1 open reading frame 94
  CKLF like MARVEL transmembrane domain containing 5
  clathrin heavy chain linker domain containing 1
  coiled-coil domain containing 33
  coronin 1A
  coronin 1C
  DAZ associated protein 2
  DBF4 zinc finger B
  dehydrogenase/reductase 4
  doublesex and mab-3 related transcription factor 3
  DPY30 domain containing 1
  DR1 associated protein 1
  EF-hand domain containing 1
  EF-hand domain containing 2
  enkurin domain containing 1
  erbb2 interacting protein
  euchromatic histone lysine methyltransferase 2
  eukaryotic translation initiation factor 3 subunit B
  FA core complex associated protein 20
  family with sequence similarity 214 member B
  family with sequence similarity 228 member A
  family with sequence similarity 90 member A1
  four and a half LIM domains 5
  glucocorticoid modulatory element binding protein 2
  golgin, RAB6 interacting
  GPN-loop GTPase 1
  GPN-loop GTPase 3
  heterogeneous nuclear ribonucleoprotein M
  histone deacetylase 5
  hook microtubule tethering protein 1
  IKAROS family zinc finger 1
  IKAROS family zinc finger 3
  inhibitor of CDK, cyclin A1 interacting protein 1
  interactor of HORMAD1 1
  interferon regulatory factor 2 binding protein 2
  intraflagellar transport 43
  ISL LIM homeobox 2
  islet cell autoantigen 1 like
  ISY1 splicing factor homolog
  kazrin, periplakin interacting protein
  kelch like family member 23
  kelch repeat and BTB domain containing 6
  kelch repeat and BTB domain containing 7
  keratin 40
  keratin 75
  keratin 80
  keratin associated protein 10-7
  keratinocyte proline rich protein
  kinesin family member 3B
  KN motif and ankyrin repeat domains 2
  LDOC1 regulator of NFKB signaling
  leiomodin 3
  leucine zipper tumor suppressor 1
  leucine zipper tumor suppressor 2
  LIM domain binding 1
  LIM domain binding 2
  LIM domain only 2
  LIM domain only 4
  LIM domains containing 1
  LYL1 basic helix-loop-helix family member
  lysine acetyltransferase 14
  lysine demethylase 5A
  lysine demethylase 5B
  MAGE family member A8
  MAP3K12 binding inhibitory protein 1
  mediator complex subunit 14
  mediator complex subunit 17
  mediator complex subunit 20
  mediator complex subunit 24
  mex-3 RNA binding family member C
  mex-3 RNA binding family member D
  microtubule associated protein RP/EB family member 1
  microtubule associated protein RP/EB family member 2
  microtubule associated protein RP/EB family member 3
  microtubule associated scaffold protein 2
  mitotic spindle positioning
  MN1 proto-oncogene, transcriptional regulator
  moesin
  Morf4 family associated protein 1 like 1
  mutS homolog 3
  myozenin 3
  NADH:ubiquinone oxidoreductase subunit AB1
  NADH:ubiquinone oxidoreductase subunit B7
  NADPH dependent diflavin oxidoreductase 1
  NADPH oxidase activator 1
  NEDD4 binding protein 2 like 2
  nescient helix-loop-helix 1
  NFKB inhibitor delta
  NGG1 interacting factor 3 like 1
  NMDA receptor synaptonuclear signaling and neuronal migration factor
  non-SMC condensin II complex subunit H2
  notch 2 N-terminal like A
  N-terminal glutamine amidase 1
  nucleoporin 62
  NUT midline carcinoma family member 1
  paired box 9
  PBX homeobox 4
  phosphodiesterase 9A
  potassium channel tetramerization domain containing 10
  POZ/BTB and AT hook containing zinc finger 1
  PR/SET domain 6
  proteasome 20S subunit alpha 1
  protein kinase cGMP-dependent 1
  protein phosphatase 1 regulatory subunit 32
  RAD50 interactor 1
  RANBP2-type and C3HC4-type zinc finger containing 1
  RB binding protein 8, endonuclease
  RB transcriptional corepressor 1
  RecQ like helicase 5
  regulation of nuclear pre-mRNA domain containing 1A
  regulation of nuclear pre-mRNA domain containing 1B
  regulation of nuclear pre-mRNA domain containing 2
  REL proto-oncogene, NF-kB subunit
  RELA proto-oncogene, NF-kB subunit
  reticulocalbin 1
  retrotransposon Gag like 8C
  Rho associated coiled-coil containing protein kinase 1
  Rho guanine nucleotide exchange factor 5
  ring finger protein 31
  ring finger protein, LIM domain interacting
  RNA polymerase II associated protein 2
  RNA polymerase II subunit A
  RNA polymerase II subunit B
  RNA polymerase II subunit C
  RNA polymerase II subunit D
  RNA polymerase II subunit G
  RNA polymerase II subunit I
  RNA polymerase II subunit J
  RNA polymerase II, I and III subunit E
  RNA polymerase II, I and III subunit F
  RNA polymerase II, I and III subunit L
  RUN and SH3 domain containing 1
  SHANK associated RH domain interactor
  signal transducer and activator of transcription 1
  signal transducer and activator of transcription 3
  single stranded DNA binding protein 2
  single stranded DNA binding protein 3
  single stranded DNA binding protein 4
  single-strand-selective monofunctional uracil-DNA glycosylase 1
  SMAD family member 2
  small glutamine rich tetratricopeptide repeat containing beta
  small nuclear RNA activating complex polypeptide 5
  Sp1 transcription factor
  S-phase kinase associated protein 1
  SPT6 homolog, histone chaperone and transcription elongation factor
  SRY-box transcription factor 5
  SSX family member 2 interacting protein
  stabilizer of axonemal microtubules 1
  stress induced phosphoprotein 1
  T cell leukemia homeobox 3
  TAL bHLH transcription factor 1, erythroid differentiation factor
  TAL bHLH transcription factor 2
  TATA-box binding protein associated factor 1
  T-box transcription factor 2
  TCF3 fusion partner
  t-complex 10 like
  tektin 3
  testis specific 10 interacting protein
  testis specific serine kinase 3
  THAP domain containing 6
  thyroid hormone receptor interactor 6
  tribbles pseudokinase 3
  tripartite motif containing 33
  tripartite motif containing 54
  tRNA splicing endonuclease subunit 15
  tRNA splicing endonuclease subunit 54
  TSC complex subunit 1
  TSC22 domain family member 4
  TSPY like 2
  tuftelin 1
  tuftelin interacting protein 11
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  ubiquitin associated and SH3 domain containing B
  ubiquitin conjugating enzyme E2 I
  ubiquitin like modifier activating enzyme 6
  USH1 protein network component sans
  vascular endothelial zinc finger 1
  VHL binding protein 1
  vimentin type intermediate filament associated coiled-coil protein
  WASH complex subunit 1
  WASP family member 1
  YEATS domain containing 2
  yippee like 3
  YOD1 deubiquitinase
  ZFP64 zinc finger protein
  zinc finger MYM-type containing 1
  zinc finger MYM-type containing 6
  zinc finger MYND-type containing 12
  zinc finger protein 185 with LIM domain
  zinc finger protein 19
  zinc finger protein 24
  zinc finger protein 250
  zinc finger protein 34
  zinc finger protein 410
  zinc finger protein 641
  zinc finger protein 655
  zinc finger protein 688
  zinc finger ZZ-type containing 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.