PSMB5, proteasome 20S subunit beta 5

PSMB5, proteasome 20S subunit beta 5

• The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

• Gene Synonyms (proteasome subunit beta type-5, PSX large multifunctional protease X, macropain epsilon chain, multicatalytic endopeptidase complex epsilon chain, proteasome (prosome, macropain) subunit, beta type, 5, proteasome beta 5 subunit, proteasome catalytic subunit 3, proteasome chain 6, proteasome epsilon chain, proteasome subunit MB1, proteasome subunit X, proteasome subunit beta 5, proteasome subunit, beta type, 5, testicular tissue protein Li 153, LMPX, MB1, X,)
• NCBI Gene ID: 5693
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P28074
  UNIPROT ID#>>A0A140VJS7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteasome 20S subunit beta 5 interacts with:

• 5'-3' exoribonuclease 1
  adaptor related protein complex 3 subunit mu 1
  adhesion regulating molecule 1
  anterior gradient 2, protein disulphide isomerase family member
  ATP binding cassette subfamily B member 5
  aurora kinase A
  autophagy and beclin 1 regulator 1
  BAG cochaperone 3
  BAG cochaperone 4
  centrosomal protein 85
  cleavage and polyadenylation specific factor 2
  cleavage factor polyribonucleotide kinase subunit 1
  coiled-coil domain containing 150
  cullin 1
  cyclin dependent kinase 20
  cyclin dependent kinase like 1
  desumoylating isopeptidase 1
  developmental pluripotency-associated 3
  dual specificity phosphatase 29
  elongation factor Tu GTP binding domain containing 2
  elongator acetyltransferase complex subunit 6
  elongator complex protein 1
  F-box protein 7
  FKBP prolyl isomerase 8
  G antigen 12G
  G antigen 2E
  glycogen phosphorylase L
  heat shock protein family H (Hsp110) member 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 5
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  IQ motif containing B1
  kinase suppressor of ras 1
  L3MBTL histone methyl-lysine binding protein 1
  L3MBTL histone methyl-lysine binding protein 4
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat kinase 2
  LSM1 homolog, mRNA degradation associated
  methylphosphate capping enzyme
  midline 2
  N-terminal glutamine amidase 1
  nuclear RNA export factor 1
  obscurin like cytoskeletal adaptor 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  proteasome (prosome, macropain) subunit, beta type 4
  proteasome 20S subunit alpha 8
  proteasome 20S subunit beta 10
  proteasome 20S subunit beta 6
  proteasome 20S subunit beta 7
  proteasome 20S subunit beta 8
  proteasome 20S subunit beta 9
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 4
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 4
  proteasome 26S subunit, non-ATPase 5
  proteasome 26S subunit, non-ATPase 6
  proteasome 26S subunit, non-ATPase 7
  proteasome 26S subunit, non-ATPase 8
  proteasome activator subunit 2
  proteasome assembly chaperone 2
  proteasome assembly chaperone 3
  proteasome maturation protein
  protein tyrosine phosphatase non-receptor type 2
  PTEN induced kinase 1
  pyrroline-5-carboxylate reductase 3
  RAD23 homolog A, nucleotide excision repair protein
  radixin
  RAN, member RAS oncogene family
  RecQ like helicase 4
  Rho family GTPase 1
  ribonuclease P/MRP subunit p38
  ring finger protein 144A
  SLX1 homolog B, structure-specific endonuclease subunit
  small nuclear ribonucleoprotein polypeptide A'
  S-phase kinase associated protein 1
  telomeric repeat binding factor 1
  TNF receptor associated factor 6
  transporter 1, ATP binding cassette subfamily B member
  transporter 2, ATP binding cassette subfamily B member
  trichoplein keratin filament binding
  tripartite motif containing 14
  ubiquilin 4
  ubiquitin C
  ubiquitin conjugating enzyme E2 C
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 7
  vimentin
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.