GRK5, G protein-coupled receptor kinase 5

GRK5, G protein-coupled receptor kinase 5

• This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]

• Gene Synonyms (G protein-coupled receptor kinase 5, g protein-coupled receptor kinase GRK5, FP2025, GPRK5,)
• NCBI Gene ID: 2869
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P34947
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

G protein-coupled receptor kinase 5 interacts with:

• ABI family member 3 binding protein
  adaptor related protein complex 3 subunit beta 1
  adaptor related protein complex 3 subunit delta 1
  adaptor related protein complex 3 subunit mu 1
  adaptor related protein complex 3 subunit mu 2
  AF4/FMR2 family member 4
  Aly/REF export factor
  ankyrin repeat and FYVE domain containing 1
  apoptotic chromatin condensation inducer 1
  autophagy related 16 like 1
  BCL2 associated transcription factor 1
  BMS1 ribosome biogenesis factor
  bromodomain adjacent to zinc finger domain 1A
  calcium binding protein 1
  cell division cycle 37, HSP90 cochaperone
  COP9 signalosome subunit 2
  COP9 signalosome subunit 4
  COP9 signalosome subunit 7A
  CTD phosphatase subunit 1
  cullin 4A
  cullin 4B
  cullin associated and neddylation dissociated 2 (putative)
  CWC22 spliceosome associated protein homolog
  cytoskeleton associated protein 5
  DDB1 and CUL4 associated factor 5
  dedicator of cytokinesis 4
  DExD-box helicase 21
  DExH-box helicase 30
  DLG associated protein 2
  elongation factor Tu GTP binding domain containing 2
  eukaryotic translation initiation factor 3 subunit A
  eukaryotic translation initiation factor 4A3
  family with sequence similarity 120A
  formin like 2
  FRY like transcription coactivator
  FtsJ RNA 2'-O-methyltransferase 3
  G protein-coupled receptor kinase 5
  G protein-coupled receptor kinase 6
  gem nuclear organelle associated protein 4
  GINS complex subunit 4
  GIT ArfGAP 1
  glutamate rich WD repeat containing 1
  glutamic-oxaloacetic transaminase 1 like 1
  glycogen synthase 1
  heat shock protein 90 alpha family class A member 1
  heat shock protein 90 alpha family class B member 1
  heat shock protein family A (Hsp70) member 4
  heterogeneous nuclear ribonucleoprotein U
  histone deacetylase 6
  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
  interleukin enhancer binding factor 3
  junction plakoglobin
  karyopherin subunit beta 1
  KN motif and ankyrin repeat domains 1
  KN motif and ankyrin repeat domains 2
  La ribonucleoprotein 1, translational regulator
  leucine rich pentatricopeptide repeat containing
  Ly1 antibody reactive
  lysozyme
  macrophage erythroblast attacher, E3 ubiquitin ligase
  MAP kinase activating death domain
  methionine adenosyltransferase 2A
  microtubule associated protein 4
  mitochondrial ribosomal protein S27
  mitogen-activated protein kinase kinase kinase kinase 4
  MMS19 homolog, cytosolic iron-sulfur assembly component
  Mov10 RISC complex RNA helicase
  MRT4 homolog, ribosome maturation factor
  Mtr4 exosome RNA helicase
  MYB binding protein 1a
  MYCN proto-oncogene, bHLH transcription factor
  myosin heavy chain 10
  myosin heavy chain 9
  myosin IC
  myosin IXB
  N-acetyltransferase 10
  nuclear assembly factor 1 ribonucleoprotein
  nuclear cap binding protein subunit 1
  nuclear factor I B
  nuclear receptor subfamily 2 group F member 1
  nuclear RNA export factor 1
  nucleolar and coiled-body phosphoprotein 1
  nucleolin
  Obg like ATPase 1
  OTU deubiquitinase 4
  patatin like phospholipase domain containing 6
  peptidylprolyl isomerase G
  phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
  pinin, desmosome associated protein
  potassium channel modulatory factor 1
  potassium channel tetramerization domain containing 5
  PPFIA binding protein 1
  prolactin induced protein
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 2
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 2 regulatory subunit Balpha
  protein phosphatase 6 regulatory subunit 3
  RAB11 family interacting protein 5
  RAN binding protein 9
  recoverin
  rhodopsin
  ribosomal protein L3
  ribosomal protein L4
  ring-box 1
  RNA binding motif single stranded interacting protein 1
  RuvB like AAA ATPase 1
  serine and arginine repetitive matrix 1
  serine and arginine rich splicing factor 1
  serine/arginine repetitive matrix 2
  serine/threonine kinase 38
  SIN3 transcription regulator family member A
  Sin3A associated protein 18
  SPATA31 subfamily A member 7
  spectrin alpha, non-erythrocytic 1
  spectrin beta, non-erythrocytic 1
  S-phase kinase associated protein 1
  spindlin 1
  spindlin family member 3
  SRSF protein kinase 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
  synuclein alpha
  synuclein beta
  synuclein gamma
  tachykinin receptor 1
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  thromboxane A2 receptor
  TNF alpha induced protein 8 like 1
  torsin family 4 member A
  transducin beta like 2
  treacle ribosome biogenesis factor 1
  Tu translation elongation factor, mitochondrial
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  U2 snRNP associated SURP domain containing
  ubiquitin conjugating enzyme E2 O
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 47
  ubiquitin specific peptidase 9 X-linked
  upstream binding transcription factor
  WD repeat domain 12
  WD repeat domain 82
  X-ray repair cross complementing 5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.