TCOF1, treacle ribosome biogenesis factor 1

TCOF1, treacle ribosome biogenesis factor 1

• This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

• Gene Synonyms (treacle protein, Treacher Collins syndrome protein, Treacher Collins-Franceschetti syndrome 1, nucleolar trafficking phosphoprotein, MFD1, TCS, TCS1, treacle,)
• NCBI Gene ID: 6949
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13428
  UNIPROT ID#>>E7ETY2
  UNIPROT ID#>>B4DRA2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

treacle ribosome biogenesis factor 1 interacts with:

• 2-oxoglutarate and iron dependent oxygenase domain containing 1
  3'-phosphoadenosine 5'-phosphosulfate synthase 1
  4-hydroxyphenylpyruvate dioxygenase like
  anaphase promoting complex subunit 13
  arrestin, beta 2
  BAG cochaperone 6
  beclin 1
  CaM kinase like vesicle associated
  cell division cycle 14A
  cell division cycle 16
  cell division cycle associated 8
  citron rho-interacting serine/threonine kinase
  cullin 7
  cullin associated and neddylation dissociated 1
  cytochrome c oxidase copper chaperone COX17
  DDB1 and CUL4 associated factor 15
  DEAD-box helicase 18
  DENN domain containing 2D
  DNA topoisomerase I
  dual specificity phosphatase 10
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  exportin 1
  glutaredoxin 5
  GPN-loop GTPase 1
  GTPase, IMAP family member 8
  H3 clustered histone 6
  H4 clustered histone 1
  HEXIM P-TEFb complex subunit 1
  immunoglobulin superfamily member 8
  inorganic pyrophosphatase 2
  integrin alpha FG-GAP repeat containing 1
  kelch repeat and BTB domain containing 8
  kinesin family member 14
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat containing G protein-coupled receptor 4
  limb development membrane protein 1 like
  lin-28 homolog A
  LINE1 type transposase domain containing 1
  lipoic acid synthetase
  methionine sulfoxide reductase B3
  microtubule associated serine/threonine kinase like
  MINDY lysine 48 deubiquitinase 4
  NHL repeat containing 2
  NHP2 ribonucleoprotein
  NOP56 ribonucleoprotein
  NOP58 ribonucleoprotein
  nuclear receptor binding SET domain protein 2
  nuclear receptor subfamily 2 group C member 2
  nucleolar and coiled-body phosphoprotein 1
  nudix hydrolase 19
  obscurin like cytoskeletal adaptor 1
  OFD1 centriole and centriolar satellite protein
  phosphopantothenoylcysteine synthetase
  PIH1 domain containing 1
  poly(A) specific ribonuclease subunit PAN2
  polynucleotide kinase 3'-phosphatase
  protein activator of interferon induced protein kinase EIF2AK2
  PWP1 homolog, endonuclein
  pyrin and HIN domain family member 1
  Ras association domain family member 8
  Ras association domain family member 9
  RecQ like helicase 4
  RNA guanylyltransferase and 5'-phosphatase
  RNA polymerase I subunit A
  RNA polymerase I subunit B
  RNA polymerase I subunit H
  S100 calcium binding protein A16
  SEC22 homolog B, vesicle trafficking protein
  septin 11
  serine and arginine rich splicing factor 10
  sirtuin 6
  sirtuin 7
  SIX homeobox 4
  speckle type BTB/POZ protein
  SPOUT domain containing methyltransferase 1
  TATA-box binding protein associated factor, RNA polymerase I subunit A
  telomeric repeat binding factor 2
  thioredoxin
  timeless circadian regulator
  transcription activation suppressor
  transmembrane 9 superfamily member 1
  treacle ribosome biogenesis factor 1
  tripartite motif containing 25
  tubulin gamma complex associated protein 4
  tumor necrosis factor
  ubiquitin C
  ubiquitin specific peptidase 44
  upstream binding transcription factor
  vir like m6A methyltransferase associated
  WD repeat domain 48
  WW domain containing E3 ubiquitin protein ligase 2
  zinc finger and BTB domain containing 38
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.