CDK11B, cyclin dependent kinase 11B

CDK11B, cyclin dependent kinase 11B

• This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

• Gene Synonyms (cyclin-dependent kinase 11B, CDC-related protein kinase p58, PITSLRE serine/threonine-protein kinase CDC2L1, cell division cycle 2-like 1 (PITSLRE proteins), cell division protein kinase 11B, galactosyltransferase-associated protein kinase p58/GTA, p58 CLK-1, CDC2L1, CDK11, CDK11-p110, CDK11-p46, CDK11-p58, CLK-1, PITSLREA, PK58, p58, p58CDC2L1, p58CLK-1,)
• NCBI Gene ID: 984
• Species: Homo sapiens (Human)
• UNIPROT ID#>>J3QR29
  UNIPROT ID#>>B4DII1
  UNIPROT ID#>>B7ZVY7
  UNIPROT ID#>>P21127
  UNIPROT ID#>>J3QR44
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cyclin dependent kinase 11B interacts with:

• adaptor related protein complex 2 subunit mu 1
  adaptor related protein complex 3 subunit delta 1
  ataxin 1
  breast carcinoma amplified sequence 2
  casein kinase 2 alpha 2
  cell division cycle 37, HSP90 cochaperone
  checkpoint kinase 2
  chromodomain helicase DNA binding protein 4
  cyclin dependent kinase 11A
  cyclin dependent kinase 11B
  cyclin dependent kinase 7
  cyclin dependent kinase 8
  cyclin L2
  enhancer of zeste 2 polycomb repressive complex 2 subunit
  estrogen receptor 1
  estrogen receptor 2
  eukaryotic translation initiation factor 3 subunit F
  fibroblast growth factor 8
  H1.4 linker histone, cluster member
  heat shock protein 90 alpha family class A member 1
  heat shock protein family A (Hsp70) member 4
  heat shock protein family A (Hsp70) member 8
  interferon regulatory factor 2 binding protein 2
  jumonji domain containing 6, arginine demethylase and lysine hydroxylase
  kinesin family member C1
  La ribonucleoprotein 7, transcriptional regulator
  lysine acetyltransferase 7
  lysine methyltransferase 2E (inactive)
  methylphosphate capping enzyme
  moesin
  neurotrophic receptor tyrosine kinase 1
  nuclear receptor subfamily 2 group C member 2
  p21 (RAC1) activated kinase 1
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  polynucleotide kinase 3'-phosphatase
  POU class 2 homeobox 1
  pyrin and HIN domain family member 1
  RAD18 E3 ubiquitin protein ligase
  RAN binding protein 9
  RAP1A, member of RAS oncogene family
  ribosomal protein S27a
  RNA binding motif protein 25
  RNA binding protein with serine rich domain 1
  round spermatid basic protein 1
  SERPINE1 mRNA binding protein 1
  small nuclear ribonucleoprotein U1 subunit 70
  transcription elongation factor A2
  transglutaminase 2
  tubulin polymerization promoting protein
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  tyrosine hydroxylase
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin related modifier 1
  vitamin D receptor
  X-ray repair cross complementing 6
  zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
  zinc finger protein 221

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.