CHD4, chromodomain helicase DNA binding protein 4

CHD4, chromodomain helicase DNA binding protein 4

• The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

• Gene Synonyms (chromodomain-helicase-DNA-binding protein 4, ATP-dependent helicase CHD4, Mi-2 autoantigen 218 kDa protein, CHD-4, Mi-2b, Mi2-BETA, SIHIWES,)
• NCBI Gene ID: 1108
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14839
  UNIPROT ID#>>F5GWX5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

chromodomain helicase DNA binding protein 4 interacts with:

• -
  5'-3' exoribonuclease 1
  5'-3' exoribonuclease 2
  8-oxoguanine DNA glycosylase
  activity dependent neuroprotector homeobox
  A-kinase anchoring protein 8
  A-kinase anchoring protein 8 like
  anterior gradient 2, protein disulphide isomerase family member
  apoptosis inhibitor 5
  apoptotic chromatin condensation inducer 1
  ATPase family AAA domain containing 3A
  ATPase family AAA domain containing 3B
  AT-rich interaction domain 1A
  BAF chromatin remodeling complex subunit BCL11A
  BAF chromatin remodeling complex subunit BCL11B
  BAF nuclear assembly factor 1
  BAG cochaperone 2
  BCAS2 pre-mRNA processing factor
  BCL2 associated transcription factor 1
  BEN domain containing 3
  biogenesis of ribosomes BRX1
  BMS1 ribosome biogenesis factor
  BOP1 ribosomal biogenesis factor
  BPI fold containing family A member 1
  bromodomain adjacent to zinc finger domain 1B
  bromodomain containing 1
  bromodomain containing 2
  bromodomain containing 4
  calcium homeostasis endoplasmic reticulum protein
  CAP-Gly domain containing linker protein 1
  casein kinase 2 alpha 1
  caspase 14
  catenin beta 1
  CD2 cytoplasmic tail binding protein 2
  CDK2 (cyclin-dependent kinase 2)-associated protein 1
  cell cycle and apoptosis regulator 2
  cell cycle associated protein 1
  cell division cycle 73
  cell division cycle and apoptosis regulator 1
  centromere protein V
  chromatin target of PRMT1
  chromobox 1
  chromobox 1
  chromobox 3
  chromobox 5
  chromodomain helicase DNA binding protein 4
  chromodomain helicase DNA binding protein 5
  chromosome 7 open reading frame 50
  cleavage and polyadenylation specific factor 2
  coiled-coil domain containing 8
  coilin
  copine 5
  C-terminal binding protein 1
  CTR9 homolog, Paf1/RNA polymerase II complex component
  cullin 4A
  cullin 7
  CXXC finger protein 1
  cyclin dependent kinase 2 associated protein 1
  DEAD-box helicase 1
  DEAD-box helicase 10
  DEAD-box helicase 17
  DEAD-box helicase 18
  DEAD-box helicase 23
  DEAD-box helicase 24
  DEAD-box helicase 27
  DEAD-box helicase 3 X-linked
  DEAD-box helicase 41
  DEAD-box helicase 42
  DEAD-box helicase 46
  DEAD-box helicase 47
  DEAD-box helicase 5
  DEAD-box helicase 54
  DEAD-box helicase 55
  DEAD-box helicase 56
  DEAH-box helicase 15
  DEK proto-oncogene
  deleted in malignant brain tumors 1
  dermcidin
  desmocollin 1
  desmoglein 1
  desmoplakin
  DExD-box helicase 21
  DExD-box helicase 39A
  DExD-box helicase 39B
  DExD-box helicase 50
  DExD-box helicase 52
  DExH-box helicase 30
  DExH-box helicase 9
  dipeptidase 2
  dipeptidase 3
  DNA ligase 3
  DNA methyltransferase 1
  DNA methyltransferase 3 beta
  DNA polymerase delta 3, accessory subunit
  DNA polymerase delta interacting protein 3
  DNA topoisomerase I
  DNA topoisomerase II alpha
  DNA topoisomerase II beta
  dyskerin pseudouridine synthase 1
  E1A binding protein p300
  EBNA1 binding protein 2
  ELAV like RNA binding protein 1
  elongation factor Tu GTP binding domain containing 2
  elongin A
  embryonic ectoderm development
  emerin
  enhancer of zeste 2 polycomb repressive complex 2 subunit
  enolase 1
  ERCC excision repair 6, chromatin remodeling factor
  ERH mRNA splicing and mitosis factor
  estrogen receptor 1
  euchromatic histone lysine methyltransferase 2
  eukaryotic translation elongation factor 1 alpha 1
  eukaryotic translation initiation factor 2 subunit alpha
  eukaryotic translation initiation factor 3 subunit A
  eukaryotic translation initiation factor 3 subunit B
  eukaryotic translation initiation factor 3 subunit C
  eukaryotic translation initiation factor 3 subunit D
  eukaryotic translation initiation factor 3 subunit F
  eukaryotic translation initiation factor 3 subunit L
  eukaryotic translation initiation factor 4 gamma 1
  eukaryotic translation initiation factor 4 gamma 2
  eukaryotic translation initiation factor 4A1
  eukaryotic translation initiation factor 4A3
  eukaryotic translation initiation factor 5
  eukaryotic translation initiation factor 6
  EWS RNA binding protein 1
  exosome component 10
  FA complementation group D2
  factor interacting with PAPOLA and CPSF1
  fatty acid binding protein 5
  F-box and WD repeat domain containing 7
  fibrillarin
  filaggrin
  filaggrin family member 2
  FMR1 autosomal homolog 2
  FMRP translational regulator 1
  forkhead box A1
  forkhead box E1
  forkhead box G1
  forkhead box J2
  forkhead box K2
  forkhead box Q1
  formin binding protein 4
  FtsJ RNA 2'-O-methyltransferase 3
  FUS RNA binding protein
  G protein nucleolar 2
  G protein nucleolar 3
  G protein nucleolar 3 like
  G3BP stress granule assembly factor 1
  galectin 7
  galectin 7B
  GATA zinc finger domain containing 2A
  GATA zinc finger domain containing 2B
  gem nuclear organelle associated protein 5
  glutamate rich WD repeat containing 1
  glutamyl-prolyl-tRNA synthetase 1
  glyceraldehyde-3-phosphate dehydrogenase
  glyoxylate reductase 1 homolog
  GTP binding protein 4
  H1.0 linker histone
  H1.10 linker histone
  H1.2 linker histone, cluster member
  H2A clustered histone 12
  H2A clustered histone 20
  H2A.X variant histone
  H2A.Z variant histone 1
  H2B clustered histone 12
  H2B clustered histone 9
  H3 clustered histone 1
  H3 clustered histone 13
  H3 clustered histone 14
  H3 clustered histone 15
  H3 clustered histone 6
  H3.3 histone A
  H3.4 histone
  H4 clustered histone 1
  H4 clustered histone 11
  H4 clustered histone 12
  H4 clustered histone 13
  H4 clustered histone 14
  H4 clustered histone 15
  H4 clustered histone 2
  H4 clustered histone 3
  H4 clustered histone 4
  H4 clustered histone 5
  H4 clustered histone 6
  H4 clustered histone 8
  H4 clustered histone 9
  H4 histone 16
  HDGF like 2
  heat shock protein family A (Hsp70) member 1 like
  heat shock protein family A (Hsp70) member 1A
  heat shock protein family A (Hsp70) member 1B
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 8
  heat shock protein family A (Hsp70) member 9
  heat shock protein family D (Hsp60) member 1
  heat shock transcription factor Y-linked 1
  helicase, lymphoid specific
  heterochromatin protein 1 binding protein 3
  heterogeneous nuclear ribonucleoprotein A/B
  heterogeneous nuclear ribonucleoprotein A0
  heterogeneous nuclear ribonucleoprotein A1
  heterogeneous nuclear ribonucleoprotein A2/B1
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein C
  heterogeneous nuclear ribonucleoprotein D
  heterogeneous nuclear ribonucleoprotein D like
  heterogeneous nuclear ribonucleoprotein F
  heterogeneous nuclear ribonucleoprotein H1
  heterogeneous nuclear ribonucleoprotein H3
  heterogeneous nuclear ribonucleoprotein K
  heterogeneous nuclear ribonucleoprotein L
  heterogeneous nuclear ribonucleoprotein M
  heterogeneous nuclear ribonucleoprotein R
  heterogeneous nuclear ribonucleoprotein U
  heterogeneous nuclear ribonucleoprotein U like 2
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 1
  histone deacetylase 2
  HIV-1 Tat specific factor 1
  hornerin
  IK cytokine
  IKAROS family zinc finger 1
  IKAROS family zinc finger 2
  IKAROS family zinc finger 3
  IKAROS family zinc finger 4
  insulin like growth factor 2 mRNA binding protein 1
  integrator complex subunit 9
  integrin subunit alpha 4
  interacts with SUPT6H, CTD assembly factor 1
  interleukin enhancer binding factor 2
  interleukin enhancer binding factor 3
  IQ motif containing GTPase activating protein 1
  junction plakoglobin
  karyopherin subunit alpha 2
  karyopherin subunit alpha 5
  karyopherin subunit alpha 6
  keratin 1
  keratin 10
  keratin 13
  keratin 14
  keratin 16
  keratin 17
  keratin 18
  keratin 19
  keratin 2
  keratin 3
  keratin 31
  keratin 32
  keratin 5
  keratin 6A
  keratin 6B
  keratin 6C
  keratin 73
  keratin 77
  keratin 78
  keratin 80
  keratin 83
  keratin 84
  keratin 9
  KH RNA binding domain containing, signal transduction associated 1
  KRI1 homolog
  KRR1 small subunit processome component homolog
  La ribonucleoprotein 1, translational regulator
  La ribonucleoprotein 7, transcriptional regulator
  lacritin
  lactotransferrin
  lamin B1
  LAS1 like ribosome biogenesis factor
  LEO1 homolog, Paf1/RNA polymerase II complex component
  leucine rich repeat containing G protein-coupled receptor 4
  ligand dependent nuclear receptor corepressor like
  lipocalin 1
  LUC7 like 2, pre-mRNA splicing factor
  LUC7 like 3 pre-mRNA splicing factor
  Ly1 antibody reactive
  lysine acetyltransferase 7
  lysine demethylase 1A
  lysine methyltransferase 2A
  lysine rich nucleolar protein 1
  lysozyme
  mab-21 like 2
  macroH2A.1 histone
  macrophage migration inhibitory factor
  marker of proliferation Ki-67
  matrin 3
  MDS1 and EVI1 complex locus
  mediator complex subunit 15
  mediator of DNA damage checkpoint 1
  melatonin receptor 1A
  metadherin
  metal regulatory transcription factor 1
  metastasis associated 1
  metastasis associated 1
  metastasis associated 1 family member 2
  metastasis associated 1 family member 3
  metastasis-associated gene family, member 2
  methyl-CpG binding domain protein 2
  methyl-CpG binding domain protein 2
  methyl-CpG binding domain protein 3
  methyl-CpG binding domain protein 3 like 1
  methyl-CpG binding domain protein 3 like 2
  microcephalin 1
  microfibril associated protein 1
  microspherule protein 1
  midasin AAA ATPase 1
  minichromosome maintenance complex component 2
  minichromosome maintenance complex component 3
  minichromosome maintenance complex component 6
  MLLT3 super elongation complex subunit
  MRE11 homolog, double strand break repair nuclease
  Mtr4 exosome RNA helicase
  MYB binding protein 1a
  MYC proto-oncogene, bHLH transcription factor
  myoglobin
  myosin heavy chain 10
  myosin heavy chain 9
  myosin light chain 6
  NACC family member 2
  N-acetyltransferase 10
  neurotrophic receptor tyrosine kinase 1
  NFKB repressing factor
  NGFI-A binding protein 1
  NGFI-A binding protein 2
  NK2 homeobox 1
  NOC2 like nucleolar associated transcriptional repressor
  NOC3 like DNA replication regulator
  non-POU domain containing octamer binding
  NOP14 nucleolar protein
  NOP2 nucleolar protein
  NOP56 ribonucleoprotein
  NOP58 ribonucleoprotein
  notch receptor 1
  nuclear cap binding subunit 3
  nuclear factor of activated T cells 1
  nuclear factor of activated T cells 2
  nuclear FMR1 interacting protein 2
  nuclear mitotic apparatus protein 1
  nuclear receptor binding SET domain protein 2
  nuclear receptor coactivator 5
  nuclear receptor subfamily 2 group C member 1
  nuclear receptor subfamily 2 group C member 2
  nuclear receptor subfamily 4 group A member 1
  nucleolar and coiled-body phosphoprotein 1
  nucleolar complex associated 4 homolog
  nucleolar protein 10
  nucleolar protein 6
  nucleolar protein 9
  nucleolar protein interacting with the FHA domain of MKI67
  nucleolar protein with MIF4G domain 1
  nucleolin
  nucleophosmin 1
  obscurin like cytoskeletal adaptor 1
  PAF1 homolog, Paf1/RNA polymerase II complex component
  Parkinsonism associated deglycase
  partner of NOB1 homolog
  PAX3 and PAX7 binding protein 1
  PC4 and SFRS1 interacting protein 1
  pericentrin
  pescadillo ribosomal biogenesis factor 1
  peter pan homolog
  PHD finger protein 14
  PHD finger protein 20 like 1
  PHD finger protein 6
  pinin, desmosome associated protein
  plakophilin 1
  pleckstrin homology domain containing A4
  pleckstrin homology domain interacting protein
  PML nuclear body scaffold
  POF1B actin binding protein
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein cytoplasmic 4
  poly(rC) binding protein 2
  poly(U) binding splicing factor 60
  polypyrimidine tract binding protein 1
  POZ/BTB and AT hook containing zinc finger 1
  PPAN-P2RY11 readthrough
  PR/SET domain 16
  pre-mRNA processing factor 19
  pre-mRNA processing factor 3
  pre-mRNA processing factor 31
  pre-mRNA processing factor 4
  pre-mRNA processing factor 40 homolog A
  pre-mRNA processing factor 4B
  pre-mRNA processing factor 6
  pre-mRNA processing factor 8
  programmed cell death 11
  prohibitin
  prohibitin 2
  prolactin induced protein
  proline rich coiled-coil 2C
  proline-serine-threonine phosphatase interacting protein 1
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 1 catalytic subunit beta
  protein phosphatase 1 catalytic subunit gamma
  PTEN induced kinase 1
  pumilio RNA binding family member 3
  PWP2 small subunit processome component
  pyruvate dehydrogenase E1 subunit alpha 1
  RAB7A, member RAS oncogene family
  RAD18 E3 ubiquitin protein ligase
  RAD21 cohesin complex component
  RAR related orphan receptor C
  RB binding protein 4, chromatin remodeling factor
  RB binding protein 7, chromatin remodeling factor
  RBM14-RBM4 readthrough
  receptor for activated C kinase 1
  recombination signal binding protein for immunoglobulin kappa J region
  RecQ like helicase 4
  replication factor C subunit 1
  replication protein A1
  replication protein A2
  replication protein A3
  REX4 homolog, 3'-5' exonuclease
  ribophorin I
  ribosomal L1 domain containing 1
  ribosomal protein L10
  ribosomal protein L10a
  ribosomal protein L11
  ribosomal protein L12
  ribosomal protein L13
  ribosomal protein L14
  ribosomal protein L15
  ribosomal protein L17
  ribosomal protein L18
  ribosomal protein L18a
  ribosomal protein L19
  ribosomal protein L21
  ribosomal protein L22
  ribosomal protein L23
  ribosomal protein L23a
  ribosomal protein L24
  ribosomal protein L26
  ribosomal protein L27
  ribosomal protein L27a
  ribosomal protein L3
  ribosomal protein L30
  ribosomal protein L31
  ribosomal protein L35
  ribosomal protein L4
  ribosomal protein L5
  ribosomal protein L6
  ribosomal protein L7
  ribosomal protein L7a
  ribosomal protein L8
  ribosomal protein L9
  ribosomal protein lateral stalk subunit P0
  ribosomal protein lateral stalk subunit P1
  ribosomal protein lateral stalk subunit P2
  ribosomal protein S10
  ribosomal protein S11
  ribosomal protein S12
  ribosomal protein S13
  ribosomal protein S14
  ribosomal protein S15
  ribosomal protein S15a
  ribosomal protein S16
  ribosomal protein S17
  ribosomal protein S18
  ribosomal protein S19
  ribosomal protein S2
  ribosomal protein S20
  ribosomal protein S24
  ribosomal protein S25
  ribosomal protein S27
  ribosomal protein S27a
  ribosomal protein S3
  ribosomal protein S3A
  ribosomal protein S4 X-linked
  ribosomal protein S5
  ribosomal protein S6
  ribosomal protein S7
  ribosomal protein S8
  ribosomal protein S9
  ribosomal protein SA
  ribosomal RNA processing 1
  ribosomal RNA processing 12 homolog
  ribosomal RNA processing 1B
  ring finger protein 2
  ring finger protein 4
  ring finger protein 8
  RNA binding motif protein 10
  RNA binding motif protein 14
  RNA binding motif protein 15
  RNA binding motif protein 15B
  RNA binding motif protein 17
  RNA binding motif protein 19
  RNA binding motif protein 25
  RNA binding motif protein 28
  RNA binding motif protein 34
  RNA binding motif protein 39
  RNA binding motif protein 5
  RNA binding motif protein X-linked
  RuvB like AAA ATPase 1
  RuvB like AAA ATPase 2
  S100 calcium binding protein A7
  S100 calcium binding protein A8
  S100 calcium binding protein A9
  scaffold attachment factor B
  SDA1 domain containing 1
  serine and arginine repetitive matrix 1
  serine and arginine rich splicing factor 1
  serine and arginine rich splicing factor 3
  serine and arginine rich splicing factor 5
  serine and arginine rich splicing factor 6
  serine and arginine rich splicing factor 7
  serine and arginine rich splicing factor 9
  serine protease 1
  serine/arginine repetitive matrix 2
  serpin family B member 12
  SERPINE1 mRNA binding protein 1
  serrate, RNA effector molecule
  SET domain containing 1A, histone lysine methyltransferase
  signal recognition particle 68
  signal recognition particle 72
  SIN3 transcription regulator family member A
  Sin3A associated protein 18
  Sin3A associated protein 30
  sirtuin 6
  sirtuin 7
  SLU7 homolog, splicing factor
  small nuclear ribonucleoprotein 13
  small nuclear ribonucleoprotein D2 polypeptide
  small nuclear ribonucleoprotein D3 polypeptide
  small nuclear ribonucleoprotein polypeptide A'
  small nuclear ribonucleoprotein polypeptide F
  small nuclear ribonucleoprotein U1 subunit 70
  small nuclear ribonucleoprotein U4/U6.U5 subunit 27
  small nuclear ribonucleoprotein U5 subunit 200
  small ubiquitin like modifier 2
  snail family transcriptional repressor 1
  snail family transcriptional repressor 2
  SNW domain containing 1
  solute carrier family 25 member 3
  spen family transcriptional repressor
  spermatid perinuclear RNA binding protein
  spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  splicing factor 3a subunit 1
  splicing factor 3a subunit 3
  splicing factor 3b subunit 1
  splicing factor 3b subunit 2
  splicing factor 3b subunit 3
  splicing factor 3b subunit 6
  splicing factor proline and glutamine rich
  splicing factor SWAP
  SPT16 homolog, facilitates chromatin remodeling subunit
  SPT5 homolog, DSIF elongation factor subunit
  SPT6 homolog, histone chaperone and transcription elongation factor
  SR-related CTD associated factor 11
  SRSF protein kinase 1
  SRY-box transcription factor 2
  staufen double-stranded RNA binding protein 1
  structural maintenance of chromosomes 1A
  structural maintenance of chromosomes 3
  structure specific recognition protein 1
  SUB1 regulator of transcription
  suppressor of variegation 3-9 homolog 1
  suprabasin
  SURP and G-patch domain containing 2
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  synaptotagmin binding cytoplasmic RNA interacting protein
  TAL bHLH transcription factor 1, erythroid differentiation factor
  TATA-box binding protein associated factor 15
  TBL1X receptor 1
  TEA domain transcription factor 2
  thioredoxin
  THO complex 1
  thymopoietin
  thyroid hormone receptor associated protein 3
  transcription factor 19
  transcription factor 7 like 2
  transducin beta like 3
  transformer 2 beta homolog
  translocated promoter region, nuclear basket protein
  treacle ribosome biogenesis factor 1
  tripartite motif containing 25
  tripartite motif containing 27
  tripartite motif containing 28
  TSR1 ribosome maturation factor
  tubulin alpha 1a
  tubulin alpha 1b
  tubulin beta 4B class IVb
  tubulin beta class I
  tuftelin interacting protein 11
  tumor protein, translationally-controlled 1
  twist family bHLH transcription factor 1
  U2 small nuclear RNA auxiliary factor 1
  U2 small nuclear RNA auxiliary factor 1 like 5
  U2 small nuclear RNA auxiliary factor 2
  U2 snRNP associated SURP domain containing
  ubiquilin 2
  ubiquitin associated and SH3 domain containing B
  ubiquitin C
  ubiquitin conjugating enzyme E2 I
  ubiquitin specific peptidase 36
  ubiquitin specific peptidase 39
  ubiquitin specific peptidase 43
  upstream binding transcription factor
  UTP14A small subunit processome component
  UTP18 small subunit processome component
  vascular cell adhesion molecule 1
  vimentin
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  voltage dependent anion channel 2
  WD repeat domain 3
  WD repeat domain 36
  WD repeat domain 77
  WW domain binding protein 11
  XPA binding protein 2
  X-ray repair cross complementing 5
  X-ray repair cross complementing 6
  YLP motif containing 1
  zinc finger and BTB domain containing 5
  zinc finger and BTB domain containing 7A
  zinc finger CCCH-type containing 18
  zinc finger CCCH-type containing, antiviral 1
  zinc finger CCHC-type containing 8
  zinc finger containing ubiquitin peptidase 1
  zinc finger homeobox 4
  zinc finger MYM-type containing 3
  zinc finger MYM-type containing 4
  zinc finger MYND-type containing 8
  zinc finger protein 219
  zinc finger protein 296
  zinc finger protein 326
  zinc finger protein 512
  zinc finger protein 512B
  zinc finger protein 524
  zinc finger protein 581
  zinc finger protein 592
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger protein 622
  zinc finger protein 638
  zinc finger protein 827
  zinc finger RNA binding protein
  zinc finger with KRAB and SCAN domains 1
  zinc finger with KRAB and SCAN domains 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.