XRCC6, X-ray repair cross complementing 6

XRCC6, X-ray repair cross complementing 6

• The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]

• Gene Synonyms (CTC75, CTCBF, G22P1, KU70, ML8, TLAA, X-ray repair cross-complementing protein 6, 5'-dRP lyase Ku70, 5'-deoxyribose-5-phosphate lyase Ku70, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II, 70 kDa subunit, CTC box binding factor 75 kDa subunit, DNA repair protein XRCC6, Ku autoantigen p70 subunit, Ku autoantigen, 70kDa, X-ray repair complementing defective repair in Chinese hamster cells 6, lupus Ku autoantigen protein p70, thyroid autoantigen 70kD (Ku antigen), thyroid autoantigen 70kDa (Ku antigen), thyroid-lupus autoantigen p70,)
• NCBI Gene ID: 2547
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DE32
  UNIPROT ID#>>B4E356
  UNIPROT ID#>>P12956
  UNIPROT ID#>>B1AHC9
  UNIPROT ID#>>A0A024R1N4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

X-ray repair cross complementing 6 interacts with:

• 3-hydroxyacyl-CoA dehydratase 3
  3-phosphoinositide dependent protein kinase 1
  ACD shelterin complex subunit and telomerase recruitment factor
  acidic nuclear phosphoprotein 32 family member E
  activator of HSP90 ATPase activity 1
  activity dependent neuroprotector homeobox
  AF4/FMR2 family member 4
  alkB homolog 5, RNA demethylase
  Aly/REF export factor
  angiopoietin like 6
  ankyrin repeat domain 28
  anterior gradient 2, protein disulphide isomerase family member
  apoptotic chromatin condensation inducer 1
  aprataxin and PNKP like factor
  ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
  ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
  arginyl-tRNA synthetase 1
  asparaginyl-tRNA synthetase 1
  ataxin 3
  AT-hook containing transcription factor 1
  ATP binding cassette subfamily D member 4
  ATP23 metallopeptidase and ATP synthase assembly factor homolog
  AT-rich interaction domain 3B
  autophagy related 16 like 1
  BAG cochaperone 2
  BBX high mobility group box domain containing
  BCL2 associated transcription factor 1
  biorientation of chromosomes in cell division 1 like 1
  BMS1 ribosome biogenesis factor
  brain abundant membrane attached signal protein 1
  bromodomain adjacent to zinc finger domain 1A
  bromodomain adjacent to zinc finger domain 1B
  bromodomain adjacent to zinc finger domain 2A
  bromodomain containing 4
  bromodomain containing 7
  BTG3 associated nuclear protein
  cactin, spliceosome C complex subunit
  calpain 11
  cap methyltransferase 1
  CASP8 and FADD like apoptosis regulator
  caspase activity and apoptosis inhibitor 1
  CDK5 regulatory subunit associated protein 1
  cell division cycle 37, HSP90 cochaperone
  cell division cycle 73
  cell division cycle associated 5
  centromere protein U
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 8
  chromatin assembly factor 1 subunit A
  chromobox 1
  chromobox 3
  chromobox 5
  chromodomain helicase DNA binding protein 1 like
  chromodomain helicase DNA binding protein 7
  chromodomain helicase DNA binding protein 8
  chromosome 11 open reading frame 58
  chromosome alignment maintaining phosphoprotein 1
  chromosome X open reading frame 56
  CKLF like MARVEL transmembrane domain containing 6
  cleavage and polyadenylation specific factor 6
  coiled-coil domain containing 57
  coiled-coil domain containing 8
  coilin
  cold shock domain containing E1
  contactin associated protein 1
  COP9 signalosome subunit 5
  coronin 1C
  craniofacial development protein 1
  cullin 2
  cullin 4B
  cullin 5
  cullin 7
  cullin associated and neddylation dissociated 1
  cyclin A1
  cyclin dependent kinase 11A
  cyclin dependent kinase 12
  cyclin K
  cytochrome p450 oxidoreductase
  DEAD-box helicase 17
  DEAD-box helicase 42
  DEAD-box helicase 46
  DEAD-box helicase 49
  DEAH-box helicase 16
  DEAH-box helicase 38
  death inducer-obliterator 1
  DENN domain containing 5A
  deoxynucleotidyltransferase terminal interacting protein 2
  developmental pluripotency-associated 3
  DExD-box helicase 21
  DExD-box helicase 39B
  DExD-box helicase 50
  DIMT1 rRNA methyltransferase and ribosome maturation factor
  DISC1 scaffold protein
  DNA ligase 3
  DNA ligase 4
  DNA polymerase delta interacting protein 3
  DNA topoisomerase I
  DNA topoisomerase II alpha
  DNA topoisomerase II beta
  DnaJ heat shock protein family (Hsp40) member B1
  dynamin 1 like
  dynein cytoplasmic 1 light intermediate chain 1
  E1A binding protein p400
  elongation factor Tu GTP binding domain containing 2
  elongin A
  embryonic ectoderm development
  EMSY transcriptional repressor, BRCA2 interacting
  EP300 interacting inhibitor of differentiation 1
  ESF1 nucleolar pre-rRNA processing protein homolog
  ETS homologous factor
  exosome component 10
  exosome component 9
  expressed sequence AI837181
  far upstream element binding protein 1
  Fas associated factor 1
  FCH and double SH3 domains 1
  G protein nucleolar 2
  galactose-3-O-sulfotransferase 4
  GATA zinc finger domain containing 2A
  general transcription factor IIA subunit 1
  general transcription factor IIE subunit 1
  general transcription factor IIE subunit 2
  general transcription factor IIF subunit 2
  general transcription factor IIi
  general transcription factor IIIC subunit 4
  glucosidase II alpha subunit
  glutaminyl-tRNA amidotransferase subunit QRSL1
  glyoxylate reductase 1 homolog
  G-patch domain containing 1
  G-patch domain containing 11
  granzyme A
  granzyme B
  Gse1 coiled-coil protein
  H2A clustered histone 4
  H2A.X variant histone
  H2A.Z variant histone 1
  H2B clustered histone 3
  H3 clustered histone 1
  H3 clustered histone 6
  H3.3 histone A
  H4 clustered histone 1
  HDGF like 2
  heat shock protein family A (Hsp70) member 5
  heat shock transcription factor 1
  heparin binding growth factor
  heterogeneous nuclear ribonucleoprotein A1
  heterogeneous nuclear ribonucleoprotein D
  heterogeneous nuclear ribonucleoprotein K
  HEXIM P-TEFb complex subunit 1
  high mobility group AT-hook 1
  high mobility group AT-hook 2
  histone acetyltransferase 1
  histone deacetylase 5
  histone deacetylase 6
  HNF1 homeobox B
  homeobox B7
  homeobox C4
  homeobox D4
  homocysteine inducible ER protein with ubiquitin like domain 1
  host cell factor C1
  huntingtin
  hydroxysteroid 17-beta dehydrogenase 10
  hydroxysteroid 17-beta dehydrogenase 4
  hypoxia inducible factor 1 subunit alpha
  hypoxia up-regulated 1
  IK cytokine
  ilvB acetolactate synthase like
  immunoglobulin superfamily member 8
  inosine monophosphate dehydrogenase 1
  integrin alpha FG-GAP repeat containing 1
  integrin subunit alpha 4
  intercellular adhesion molecule 1
  interferon gamma inducible protein 16
  interferon induced protein with tetratricopeptide repeats 5
  interferon regulatory factor 2
  interleukin enhancer binding factor 2
  interleukin enhancer binding factor 3
  ISG15 ubiquitin like modifier
  jumonji domain containing 1C
  Jun proto-oncogene, AP-1 transcription factor subunit
  junction plakoglobin
  Jupiter microtubule associated homolog 2
  KH-type splicing regulatory protein
  KIAA0408
  kinesin family member 23
  kinesin family member 4A
  KRAS proto-oncogene, GTPase
  KRI1 homolog
  La ribonucleoprotein 7, transcriptional regulator
  lamin A/C
  lamin B receptor
  leucine rich pentatricopeptide repeat containing
  leucine rich repeat containing 59
  leucine rich repeats and WD repeat domain containing 1
  lysine acetyltransferase 2A
  lysine acetyltransferase 2B
  macroH2A.1 histone
  marker of proliferation Ki-67
  matrin 3
  MAX dimerization protein MGA
  MDM2 proto-oncogene
  mediator complex subunit 1
  mediator of DNA damage checkpoint 1
  metadherin
  methyl-CpG binding protein 2
  methylphosphate capping enzyme
  methyltransferase like 14
  methyltransferase like 3
  microfibril associated protein 1
  microtubule associated protein 4
  microtubule associated serine/threonine kinase 3
  minichromosome maintenance complex component 2
  mitogen-activated protein kinase 13
  mitogen-activated protein kinase 8
  mitogen-activated protein kinase kinase 5
  mitogen-activated protein kinase kinase kinase kinase 2
  mono-ADP ribosylhydrolase 1
  motor neuron and pancreas homeobox 1
  Mov10 RISC complex RNA helicase
  MRE11 homolog, double strand break repair nuclease
  msh homeobox 2
  mutS homolog 2
  mutS homolog 6
  MYB binding protein 1a
  MYC proto-oncogene, bHLH transcription factor
  myocardin related transcription factor B
  myosin heavy chain 10
  myosin heavy chain 9
  myristoylated alanine rich protein kinase C substrate
  N-acetyltransferase 10
  N-alpha-acetyltransferase 15, NatA auxiliary subunit
  NEDD8 activating enzyme E1 subunit 1
  negative elongation factor complex member E
  neurofibromin 2
  neurotrophic receptor tyrosine kinase 1
  neutrophil cytosolic factor 4
  nitrilase 1
  NK2 homeobox 1
  N-myc downstream regulated 1
  non-POU domain containing octamer binding
  NOP2 nucleolar protein
  NOP53 ribosome biogenesis factor
  notch receptor 1
  NSFL1 cofactor
  nuclear autoantigenic sperm protein
  nuclear factor of activated T cells 1
  nuclear factor of activated T cells 2
  nuclear mitotic apparatus protein 1
  nuclear receptor coactivator 6
  nuclear receptor corepressor 1
  nuclear receptor subfamily 1 group H member 4
  nuclear receptor subfamily 2 group C member 2
  nuclear RNA export factor 1
  nuclear transcription factor, X-box binding 1
  nuclear VCP like
  nucleolar protein 11
  nucleolar protein 8
  nucleolar protein interacting with the FHA domain of MKI67
  nucleolin
  nucleoporin 153
  nucleoporin 50
  nudix hydrolase 21
  nudix hydrolase 5
  O-6-methylguanine-DNA methyltransferase
  obscurin like cytoskeletal adaptor 1
  origin recognition complex subunit 1
  origin recognition complex subunit 2
  origin recognition complex subunit 3
  origin recognition complex subunit 4
  origin recognition complex subunit 6
  pancreatic and duodenal homeobox 1
  paraspeckle component 1
  parkin RBR E3 ubiquitin protein ligase
  PAX interacting protein 1
  PAXX non-homologous end joining factor
  PC4 and SFRS1 interacting protein 1
  PCF11 cleavage and polyadenylation factor subunit
  PDGFA associated protein 1
  PDZ and LIM domain 1
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  peptidylprolyl isomerase D
  peptidylprolyl isomerase like 2
  peptidylprolyl isomerase like 4
  peroxisome proliferator activated receptor gamma
  PEST proteolytic signal containing nuclear protein
  PHD and ring finger domains 1
  PHD finger protein 1
  PHD finger protein 3
  phenylalanyl-tRNA synthetase subunit beta
  phosphoglycerate mutase 1
  phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
  phosphorylated adaptor for RNA export
  PIH1 domain containing 1
  plasminogen receptor with a C-terminal lysine
  platelet activating factor acetylhydrolase 1b catalytic subunit 3
  platelet and endothelial cell adhesion molecule 1
  pleckstrin homology domain containing A4
  poly(A) polymerase alpha
  poly(ADP-ribose) polymerase 2
  poly(rC) binding protein 1
  polynucleotide kinase 3'-phosphatase
  potassium voltage-gated channel subfamily D member 3
  POU class 2 homeobox 1
  POU class 2 homeobox 2
  pre-mRNA processing factor 19
  pre-mRNA processing factor 3
  pre-mRNA processing factor 40 homolog A
  pre-mRNA processing factor 8
  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
  progestagen associated endometrial protein
  progesterone receptor
  prohibitin
  prohibitin 2
  prolactin induced protein
  proliferating cell nuclear antigen
  proline rich nuclear receptor coactivator 2
  prolyl-tRNA synthetase 2, mitochondrial
  proteasome 20S subunit alpha 3
  proteasome 26S subunit, non-ATPase 4
  proteasome activator subunit 3
  protection of telomeres 1
  protein disulfide isomerase family A member 3
  protein inhibitor of activated STAT 2
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 1 catalytic subunit gamma
  protein phosphatase 1 regulatory subunit 10
  protein phosphatase 4 regulatory subunit 3A
  protein phosphatase 6 catalytic subunit
  protein phosphatase, Mg2+/Mn2+ dependent 1G
  PTEN induced kinase 1
  PTTG1 regulator of sister chromatid separation, securin
  pyruvate dehydrogenase complex component X
  pyruvate dehydrogenase kinase 1
  RALY heterogeneous nuclear ribonucleoprotein
  RAN binding protein 3
  RAP1A, member of RAS oncogene family
  RAP1B, member of RAS oncogene family
  RAS p21 protein activator 1
  RAS related 2
  RB binding protein 4, chromatin remodeling factor
  RB binding protein 6, ubiquitin ligase
  RecQ like helicase 4
  regulation of nuclear pre-mRNA domain containing 2
  regulator of G protein signaling 2
  regulatory associated protein of MTOR complex 1
  replication factor C subunit 1
  replication protein A1
  replication protein A2
  replication protein A3
  replication timing regulatory factor 1
  retinoid X receptor alpha
  REX4 homolog, 3'-5' exonuclease
  ribosomal protein lateral stalk subunit P1
  ribosomal protein S10
  ribosomal protein SA
  ribosomal RNA processing 15 homolog
  ribosomal RNA processing 1B
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 123
  ring finger protein 126
  ring finger protein 126
  ring finger protein 146
  ring finger protein 31
  RNA binding motif protein 10
  RNA binding motif protein 26
  RNA binding motif protein 27
  RNA binding motif protein 33
  RNA binding motif protein 39
  round spermatid basic protein 1 like
  RTF1 homolog, Paf1/RNA polymerase II complex component
  RuvB like AAA ATPase 1
  SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
  SAP domain containing ribonucleoprotein
  SAP30 binding protein
  scaffold attachment factor B2
  Scm polycomb group protein like 2
  secreted protein acidic and cysteine rich
  selenoprotein F
  septin 2
  serine and arginine rich splicing factor 3
  serine and arginine rich splicing factor 7
  serine hydroxymethyltransferase 2
  serine/arginine repetitive matrix 2
  serpin family A member 2 (gene/pseudogene)
  serpin family B member 9
  serum response factor binding protein 1
  SET nuclear proto-oncogene
  shugoshin 1
  sirtuin 3
  sirtuin 6
  sirtuin 7
  SKI like proto-oncogene
  SLU7 homolog, splicing factor
  SMAD family member 3
  SMAD family member 7
  SMAD specific E3 ubiquitin protein ligase 1
  small nuclear ribonucleoprotein 13
  small nuclear ribonucleoprotein polypeptide A'
  small nuclear ribonucleoprotein polypeptide N
  small nuclear ribonucleoprotein U5 subunit 200
  small RNA binding exonuclease protection factor La
  small ubiquitin like modifier 2
  snail family transcriptional repressor 1
  SNW domain containing 1
  solute carrier family 25 member 1
  spectrin alpha, erythrocytic 1
  spen family transcriptional repressor
  spermatid perinuclear RNA binding protein
  spindle apparatus coiled-coil protein 1
  spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  spliceosome associated factor 3, U4/U6 recycling protein
  splicing factor 1
  splicing factor 3a subunit 1
  splicing factor 3b subunit 1
  splicing factor 3b subunit 2
  splicing factor proline and glutamine rich
  SPT16 homolog, facilitates chromatin remodeling subunit
  SPT5 homolog, DSIF elongation factor subunit
  SRA stem-loop interacting RNA binding protein
  SR-related CTD associated factor 11
  SRY-box transcription factor 2
  ST13 Hsp70 interacting protein
  stathmin 1
  stathmin 2
  structural maintenance of chromosomes flexible hinge domain containing 1
  structure specific recognition protein 1
  SUB1 regulator of transcription
  succinate dehydrogenase complex flavoprotein subunit A
  succinate dehydrogenase complex subunit C
  superoxide dismutase 1
  surfeit 6
  SURP and G-patch domain containing 1
  SURP and G-patch domain containing 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  switching B cell complex subunit SWAP70
  syntrophin alpha 1
  tachykinin precursor 1
  TAL bHLH transcription factor 1, erythroid differentiation factor
  TAR DNA binding protein
  TATA-box binding protein associated factor 1
  TATA-box binding protein associated factor 1 like
  TATA-box binding protein associated factor 15
  T-box transcription factor 3
  telomerase reverse transcriptase
  telomerase RNA component interacting RNase
  telomeric repeat binding factor 1
  telomeric repeat binding factor 2
  TERF1 interacting nuclear factor 2
  TERF2 interacting protein
  testis expressed 10
  THO complex 2
  thymopoietin
  thyroid hormone receptor alpha
  thyroid hormone receptor associated protein 3
  thyroid hormone receptor beta
  thyroid hormone receptor interactor 12
  thyroid hormone receptor interactor 4
  TNFAIP3 interacting protein 2
  tonsoku like, DNA repair protein
  TOR signaling pathway regulator
  TOX high mobility group box family member 4
  TPX2 microtubule nucleation factor
  transcription elongation regulator 1
  transcription factor 20
  transcription factor 4
  transcription factor 7 like 2
  transcription factor AP-2 alpha
  transcription factor CP2
  transcriptional adaptor 3
  transketolase
  translocated promoter region, nuclear basket protein
  trinucleotide repeat containing 18
  tripartite motif containing 25
  tripartite motif containing 28
  tRNA methyltransferase 1 like
  tropomodulin 3
  tubulin folding cofactor D
  tuftelin interacting protein 11
  tumor protein p53
  tumor protein p53 binding protein 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  U2 small nuclear RNA auxiliary factor 2
  ubiquilin 2
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 S
  ubiquitin C-terminal hydrolase L3
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 50
  upstream transcription factor 1
  UTP14A small subunit processome component
  UTP3 small subunit processome component
  vascular cell adhesion molecule 1
  vav guanine nucleotide exchange factor 1
  VHL binding protein 1
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  VRK serine/threonine kinase 1
  VRK serine/threonine kinase 3
  WAPL cohesin release factor
  WD repeat domain 36
  WD repeat domain 43
  WD repeat domain 70
  WD repeat domain 76
  WIZ zinc finger
  WRN RecQ like helicase
  WW domain binding protein 4
  WW domain containing adaptor with coiled-coil
  XPA binding protein 2
  XPC complex subunit, DNA damage recognition and repair factor
  X-ray repair cross complementing 1
  X-ray repair cross complementing 4
  X-ray repair cross complementing 5
  X-ray repair cross complementing 6
  Yes1 associated transcriptional regulator
  YLP motif containing 1
  YTH domain containing 2
  YY1 associated factor 2
  YY1 transcription factor
  zinc finger and BTB domain containing 33
  zinc finger and BTB domain containing 38
  zinc finger and BTB domain containing 7A
  zinc finger CCCH-type containing 11A
  zinc finger CCCH-type containing 18
  zinc finger CCCH-type containing 4
  zinc finger MYND-type containing 8
  zinc finger protein 280C
  zinc finger protein 281
  zinc finger protein 318
  zinc finger protein 362
  zinc finger protein 512
  zinc finger protein 512B
  zinc finger protein 638
  zinc finger protein 711
  zinc finger protein 830
  zinc finger RANBP2-type containing 2
  zinc finger RNA binding protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.