AP2M1, adaptor related protein complex 2 subunit mu 1

AP2M1, adaptor related protein complex 2 subunit mu 1

• This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

• Gene Synonyms (AP-2 complex subunit mu, AP-2 mu 2 chain, HA2 50 kDA subunit, adaptin-mu2, adaptor protein complex AP-2 subunit mu, adaptor related protein complex 2 mu 1 subunit, adaptor-related protein complex 2 subunit mu, clathrin adaptor complex AP2, mu subunit, clathrin assembly protein complex 2 medium chain, clathrin assembly protein complex 2 mu medium chain, clathrin coat adaptor protein AP50, clathrin coat assembly protein AP50, clathrin coat-associated protein AP50, clathrin-associated/assembly/adaptor protein, medium 1, plasma membrane adaptor AP-2 50 kDa protein, plasma membrane adaptor AP-2 50kDA protein, AP50, CLAPM1, MRD60, mu2,)
• NCBI Gene ID: 1173
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96CW1
  UNIPROT ID#>>B4DNB9
  UNIPROT ID#>>E9PFW3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

adaptor related protein complex 2 subunit mu 1 interacts with:

• 6-pyruvoyltetrahydropterin synthase
  actin, beta
  adaptor related protein complex 1 subunit gamma 2
  adaptor related protein complex 1 subunit sigma 1
  adaptor related protein complex 1 subunit sigma 2
  adaptor related protein complex 1 subunit sigma 3
  adaptor related protein complex 2 subunit mu 1
  adaptor related protein complex 2 subunit sigma 1
  ADP ribosylation factor GTPase activating protein 1
  A-kinase anchoring protein 11
  anillin actin binding protein
  ankyrin repeat domain 28
  ankyrin repeat domain 52
  anterior gradient 2, protein disulphide isomerase family member
  AP2 associated kinase 1
  APC membrane recruitment protein 1
  ataxin 1 like
  ataxin 2 like
  autophagy related 16 like 1
  autophagy related 9A
  BMP2 inducible kinase
  bromodomain containing 7
  calcium binding and coiled-coil domain 1
  calmodulin-like 3
  casein kinase 1, epsilon
  casein kinase 2 beta
  catenin beta 1
  catenin delta 1
  cell division cycle 14A
  chromodomain helicase DNA binding protein 8
  chromosome 1 open reading frame 226
  chromosome 1 open reading frame 35
  chromosome X open reading frame 51A
  chromosome X open reading frame 51B
  clathrin heavy chain
  clathrin interactor 1
  clathrin light chain B
  collectin subfamily member 12
  coronin 1C
  coronin 7
  coronin, actin binding protein 1C
  CRK proto-oncogene, adaptor protein
  cryptochrome circadian regulator 1
  cryptochrome circadian regulator 2
  C-type lectin domain family 4 member M
  cullin 3
  cyclin G associated kinase
  CYLD lysine 63 deubiquitinase
  cytotoxic T-lymphocyte associated protein 4
  DAB adaptor protein 2
  DDB1 and CUL4 associated factor 1
  DEAD-box helicase 3 X-linked
  DEAD-box helicase 47
  DEAD-box helicase 6
  developmental pluripotency associated 2
  DExD-box helicase 39B
  diacylglycerol kinase iota
  DIMT1 rRNA methyltransferase and ribosome maturation factor
  dishevelled segment polarity protein 2
  DnaJ heat shock protein family (Hsp40) member C6
  doublecortin
  drebrin 1
  EH domain containing 2
  ELL associated factor 1
  elongation factor Tu GTP binding domain containing 2
  enhancer of mRNA decapping 4
  envoplakin
  EPH receptor A2
  epidermal growth factor receptor
  epidermal growth factor receptor pathway substrate 15
  epidermal growth factor receptor pathway substrate 15 like 1
  epsin 1
  estrogen receptor 1
  eukaryotic translation elongation factor 1 alpha 1
  eukaryotic translation initiation factor 1A domain containing
  exportin 1
  family with sequence similarity 199, X-linked
  family with sequence similarity 90 member A1
  fatty acid synthase
  FCH and mu domain containing endocytic adaptor 2
  fibronectin 1
  filamin A
  filamin, beta
  FMR1 autosomal homolog 2
  furin, paired basic amino acid cleaving enzyme
  G protein-coupled receptor 156
  G2 and S-phase expressed 1
  GC-rich promoter binding protein 1 like 1
  glial fibrillary acidic protein
  glucagon like peptide 1 receptor
  glutamate ionotropic receptor NMDA type subunit 2B
  glyceraldehyde-3-phosphate dehydrogenase
  growth factor receptor bound protein 2
  GULP PTB domain containing engulfment adaptor 1
  H2B clustered histone 10
  H2B clustered histone 13
  H2B clustered histone 21
  H2B clustered histone 4
  H2B clustered histone 6
  H2B clustered histone 7
  H2B clustered histone 8
  heat shock protein family A (Hsp70) member 1 like
  heat shock protein family A (Hsp70) member 1A
  heat shock protein family A (Hsp70) member 1B
  heat shock protein family A (Hsp70) member 6
  heat shock protein family A (Hsp70) member 8
  heat shock protein family A (Hsp70) member 9
  heterogeneous nuclear ribonucleoprotein A2/B1
  HEXIM P-TEFb complex subunit 1
  HEXIM P-TEFb complex subunit 2
  histone acetyltransferase 1
  HRas proto-oncogene, GTPase
  IKAROS family zinc finger 1
  integrin subunit alpha 4
  interferon alpha and beta receptor subunit 1
  intersectin 1
  intersectin 2
  inturned planar cell polarity protein
  IQ motif containing GTPase activating protein 1
  kelch repeat and BTB domain containing 6
  kelch repeat and BTB domain containing 7
  keratin 1
  keratin 10
  keratin 14
  keratin 16
  keratin 17
  keratin 2
  keratin 3
  keratin 5
  keratin 6A
  keratin 6B
  keratin 73
  keratin 77
  keratin 79
  keratin 9
  KIAA0232
  kinesin family member 13A
  KRAS proto-oncogene, GTPase
  L1 cell adhesion molecule
  ligand of numb-protein X 1
  LIM domain and actin binding 1
  LIM domain and actin binding 1
  lymphocyte antigen 9
  lysine rich nucleolar protein 1
  lysosomal associated membrane protein 1
  mab-21 like 2
  mab-21 like 3
  MAGE family member C2
  MAGE family member D4B
  male-enhanced antigen 1
  mannan binding lectin serine peptidase 1
  maturin, neural progenitor differentiation regulator homolog
  MDS1 and EVI1 complex locus
  mediator complex subunit 4
  membrane palmitoylated protein 1
  metaxin 2
  mex-3 RNA binding family member C
  microfibril associated protein 1
  microtubule affinity regulating kinase 2
  microtubule associated protein 1 light chain 3 alpha
  microtubule associated protein 4
  mindbomb E3 ubiquitin protein ligase 1
  mitochondrial ribosomal protein L58
  multiple EGF like domains 10
  MYC proto-oncogene, bHLH transcription factor
  myosin heavy chain 9
  myosin IC
  myosin VI
  myosin XIX
  myosin XVIIIA
  myosin, heavy polypeptide 10, non-muscle
  myosin, heavy polypeptide 9, non-muscle
  myotubularin related protein 4
  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
  N-alpha-acetyltransferase 11, NatA catalytic subunit
  NECAP endocytosis associated 1
  NECAP endocytosis associated 2
  NFKB activating protein
  nitric oxide synthase 1 adaptor protein
  NKAP domain containing 1
  N-myc downstream regulated 1
  nuclear receptor corepressor 2
  nuclear receptor subfamily 2 group C member 2
  NUMB endocytic adaptor protein
  NUMB endocytic adaptor protein
  OCRL inositol polyphosphate-5-phosphatase
  OTU deubiquitinase 6B
  PDZ and LIM domain 7
  period circadian regulator 1
  periphilin 1
  peroxisomal biogenesis factor 14
  peroxisomal biogenesis factor 5
  phosphatidylinositol binding clathrin assembly protein
  pleckstrin homology domain containing A4
  pleiotropic regulator 1
  poly(rC) binding protein 1
  potassium inwardly rectifying channel subfamily J member 11
  potassium voltage-gated channel subfamily Q member 1
  PR/SET domain 16
  praja ring finger ubiquitin ligase 1
  praja ring finger ubiquitin ligase 2
  pre-mRNA processing factor 18
  pre-mRNA processing factor 38A
  proline rich 13
  protein kinase cAMP-activated catalytic subunit beta
  protein kinase cAMP-dependent type I regulatory subunit beta
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 1 catalytic subunit beta
  protein phosphatase 6 regulatory subunit 2
  RAB7A, member RAS oncogene family
  radial spoke head 14 homolog
  Ral GTPase activating protein catalytic subunit alpha 1
  ralA binding protein 1
  RALBP1 associated Eps domain containing 1
  RALBP1 associated Eps domain containing 2
  ribosomal protein L22
  ribosomal protein L38
  ribosomal protein S27a
  ribosomal protein S6 kinase A1
  ribosomal protein S6 kinase A2
  ribosomal protein S6 kinase A3
  ribosomal RNA processing 12 homolog
  ring finger 111
  ring finger protein 11
  ring finger protein 111
  ring finger protein 138
  RIO kinase 1
  RNA exonuclease 1 homolog
  RUN domain containing 3A
  RuvB like AAA ATPase 2
  serine/threonine kinase 11
  serpin family B member 12
  SHC adaptor protein 1
  solute carrier family 25 member 41
  sorting nexin 29
  sorting nexin 9
  spectrin beta, non-erythrocytic 1
  sperm antigen with calponin homology and coiled-coil domains 1 like
  splicing factor proline and glutamine rich
  staufen double-stranded RNA binding protein 1
  stonin 2
  suppressor of cytokine signaling 6
  synaptic vesicle glycoprotein 2A
  synaptojanin 1
  synaptopodin
  syntaxin 8
  tankyrase
  tankyrase 2
  TBC1 domain family member 5
  testin LIM domain protein
  transcription activation suppressor
  transcription factor AP-2 alpha
  trans-golgi network protein 2
  translation machinery associated 16 homolog
  tripartite motif containing 25
  tripartite motif containing 28
  tropomodulin 3
  tropomyosin 1, alpha
  tubulin alpha 1a
  tubulin alpha 1b
  tubulin alpha 1c
  tubulin alpha 4b
  tubulin beta 2A class IIa
  tubulin beta 3 class III
  tubulin beta 4B class IVb
  tubulin beta class I
  tumor suppressing subtransferable candidate 4
  ubiquilin 2
  ubiquitin C
  UTP25 small subunit processor component
  valosin containing protein
  vascular cell adhesion molecule 1
  zinc finger and BTB domain containing 8A
  zinc finger and BTB domain containing 8B
  zinc finger protein 581
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.