PCBP1, poly(rC) binding protein 1

PCBP1, poly(rC) binding protein 1

• This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]

• Gene Synonyms (HEL-S-85, HNRPE1, HNRPX, hnRNP-E1, hnRNP-X, poly(rC)-binding protein 1, alpha-CP1, epididymis secretory protein Li 85, heterogeneous nuclear ribonucleoprotein E1, heterogenous nuclear ribonucleoprotein E1, heterogenous nuclear ribonucleoprotein X, nucleic acid-binding protein SUB2.3,)
• NCBI Gene ID: 5093
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15365
  UNIPROT ID#>>Q53SS8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

poly(rC) binding protein 1 interacts with:

• AAR2 splicing factor
  acidic nuclear phosphoprotein 32 family member A
  acyl-CoA thioesterase 7
  aldo-keto reductase family 1 member A1
  allograft inflammatory factor 1-like
  anoctamin 7
  apoptosis inhibitor 5
  apoptotic chromatin condensation inducer 1
  arginine and glutamate rich 1
  argonaute RISC catalytic component 2
  ataxin 2 like
  BICD cargo adaptor 2
  bolA family member 1
  bolA family member 2
  calcium regulated heat stable protein 1
  calmodulin regulated spectrin associated protein family member 2
  casein kinase 1, epsilon
  CCCTC-binding factor
  cell division cycle 37, HSP90 cochaperone
  cell division cycle 73
  centrosomal protein 55
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 4
  checkpoint kinase 2
  cleavage and polyadenylation specific factor 7
  coactosin like F-actin binding protein 1
  COP9 signalosome subunit 5
  COPI coat complex subunit epsilon
  CUGBP Elav-like family member 2
  CUGBP Elav-like family member 3
  cullin 1
  cullin 2
  cullin 5
  cullin 7
  cullin associated and neddylation dissociated 1
  CYFIP related Rac1 interactor B
  DAZ associated protein 1
  DEAD-box helicase 24
  DEAD-box helicase 3 Y-linked
  DEAH-box helicase 36
  destrin, actin depolymerizing factor
  DExD-box helicase 39B
  DExD-box helicase 52
  DIMT1 rRNA methyltransferase and ribosome maturation factor
  DNA polymerase delta 1, catalytic subunit
  DNA polymerase eta
  dynein light chain LC8-type 1
  dynein light chain LC8-type 2
  EBNA1 binding protein 2
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  elongin B
  elongin BC and polycomb repressive complex 2 associated protein
  elongin C
  embryonic ectoderm development
  ESF1 nucleolar pre-rRNA processing protein homolog
  eukaryotic translation initiation factor 2 alpha kinase 2
  eukaryotic translation initiation factor 2 subunit beta
  family with sequence similarity 120A
  far upstream element binding protein 1
  far upstream element binding protein 3
  fascin actin-bundling protein 1
  F-box protein 11
  F-box protein 6
  F-box protein 7
  FMR1 autosomal homolog 2
  fumarylacetoacetate hydrolase domain containing 1
  G protein nucleolar 3
  glutamate rich WD repeat containing 1
  glyoxalase domain containing 4
  glyoxylate and hydroxypyruvate reductase
  H4 clustered histone 1
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  heme binding protein 1
  heterogeneous nuclear ribonucleoprotein A0
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein L like
  heterogeneous nuclear ribonucleoprotein R
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 4
  HNF1 homeobox B
  huntingtin interacting protein K
  innate immunity activator
  insulin like growth factor 2 mRNA binding protein 2
  insulin like growth factor 2 mRNA binding protein 3
  KH RNA binding domain containing, signal transduction associated 1
  kinesin family member 1B
  Kruppel like factor 1
  La ribonucleoprotein 7, transcriptional regulator
  LSM12 homolog
  LUC7 like
  LUC7 like 2, pre-mRNA splicing factor
  matrin 3
  mediator complex subunit 20
  methylphosphate capping enzyme
  methyltransferase like 14
  methyltransferase like 3
  mex-3 RNA binding family member C
  microtubule associated serine/threonine kinase 3
  mitochondrial carrier 2
  mitochondrial ribosomal protein L4
  mitochondrial ribosomal protein S18A
  mitochondrial ribosomal protein S2
  mitochondrial ribosomal protein S22
  mitochondrial ribosomal protein S34
  mitogen-activated protein kinase kinase 3
  mitogen-activated protein kinase kinase kinase kinase 3
  N-acetyltransferase 10
  NADH:ubiquinone oxidoreductase core subunit S7
  NOP16 nucleolar protein
  NPR2 like, GATOR1 complex subunit
  nuclear FMR1 interacting protein 2
  nuclear receptor binding SET domain protein 2
  nuclear receptor subfamily 2 group C member 2
  nudix hydrolase 11
  obscurin like cytoskeletal adaptor 1
  OCIA domain containing 1
  OTU deubiquitinase 4
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  palmitoyl-protein thioesterase 1
  PDZ and LIM domain 7
  pelota mRNA surveillance and ribosome rescue factor
  peptidylprolyl isomerase E
  peptidylprolyl isomerase G
  peptidylprolyl isomerase like 3
  peroxiredoxin 2
  peter pan homolog
  PHD finger protein 19
  PHD finger protein 3
  phosphatidylinositol transfer protein beta
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  phosphofructokinase, muscle
  phosphofructokinase, platelet
  phosphoinositide-3-kinase regulatory subunit 1
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  phosphoserine aminotransferase 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  PML nuclear body scaffold
  poly(A) binding protein cytoplasmic 1
  poly(A) specific ribonuclease subunit PAN2
  poly(rC) binding protein 2
  poly(rC) binding protein 3
  poly(rC) binding protein 4
  poly(U) binding splicing factor 60
  polycomb group ring finger 2
  polypyrimidine tract binding protein 1
  polypyrimidine tract binding protein 3
  pre-mRNA processing factor 3
  pre-mRNA processing factor 4
  pre-mRNA processing factor 6
  pre-mRNA processing factor 8
  programmed cell death 6
  prohibitin
  proteasome 20S subunit alpha 3
  protection of telomeres 1
  protein activator of interferon induced protein kinase EIF2AK2
  protein phosphatase 1 catalytic subunit gamma
  protein phosphatase 6 catalytic subunit
  pyruvate kinase M1/2
  QKI, KH domain containing RNA binding
  Rac GTPase activating protein 1
  RAD18 E3 ubiquitin protein ligase
  RALY heterogeneous nuclear ribonucleoprotein
  RAN, member RAS oncogene family
  Ras association domain family member 10
  Ras association domain family member 9
  RB binding protein 6, ubiquitin ligase
  receptor for activated C kinase 1
  RecQ like helicase
  RecQ like helicase 4
  replication factor C subunit 1
  replication factor C subunit 3
  replication factor C subunit 5
  replication initiator 1
  ribosomal protein L10
  ribosomal protein L11
  ribosomal protein L12
  ribosomal protein L13a
  ribosomal protein L14
  ribosomal protein L15
  ribosomal protein L18
  ribosomal protein L18a
  ribosomal protein L19
  ribosomal protein L23
  ribosomal protein L24
  ribosomal protein L26
  ribosomal protein L27
  ribosomal protein L27a
  ribosomal protein L28
  ribosomal protein L3
  ribosomal protein L30
  ribosomal protein L31
  ribosomal protein L35a
  ribosomal protein L36
  ribosomal protein L4
  ribosomal protein L5
  ribosomal protein L6
  ribosomal protein L7
  ribosomal protein L7a
  ribosomal protein L8
  ribosomal protein L9
  ribosomal protein lateral stalk subunit P0
  ribosomal protein lateral stalk subunit P2
  ribosomal protein S14
  ribosomal protein S15a
  ribosomal protein S16
  ribosomal protein S2
  ribosomal protein S23
  ribosomal protein S25
  ribosomal protein S26
  ribosomal protein S3A
  ribosomal protein S4 X-linked
  ribosomal protein S6
  ribosomal protein S6 kinase B2
  ribosomal protein S8
  ribosomal protein S9
  ribosomal RNA processing 1
  ribosomal RNA processing 15 homolog
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 31
  ring-box 1
  RIO kinase 1
  RNA binding fox-1 homolog 2
  RNA binding motif protein 10
  RNA binding motif protein 11
  RNA binding motif protein 12
  RNA binding motif protein 14
  RNA binding motif protein 17
  RNA binding motif protein 3
  RNA binding motif protein 39
  RNA binding motif protein 42
  RNA binding protein, mRNA processing factor 2
  RuvB like AAA ATPase 1
  RuvB like AAA ATPase 2
  serine and arginine repetitive matrix 1
  serine and arginine rich splicing factor 3
  serine and arginine rich splicing factor 6
  SET domain and mariner transposase fusion gene
  signal recognition particle 72
  SMAD specific E3 ubiquitin protein ligase 1
  small nuclear ribonucleoprotein D2 polypeptide
  small nuclear ribonucleoprotein polypeptide A
  small nuclear ribonucleoprotein U1 subunit 70
  snail family transcriptional repressor 1
  SNW domain containing 1
  solute carrier family 25 member 1
  S-phase kinase associated protein 1
  spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  splicing factor 1
  splicing factor 3a subunit 2
  splicing factor proline and glutamine rich
  SRSF protein kinase 1
  SRSF protein kinase 2
  SRSF protein kinase 3
  staufen double-stranded RNA binding protein 1
  STIP1 homology and U-box containing protein 1
  stress induced phosphoprotein 1
  structural maintenance of chromosomes 1A
  structural maintenance of chromosomes 3
  superoxide dismutase 1
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  synaptotagmin binding cytoplasmic RNA interacting protein
  synuclein gamma
  TAR DNA binding protein
  TATA-box binding protein associated factor 10
  TATA-box binding protein associated factor 15
  telomeric repeat binding factor 2
  thioredoxin
  thymopoietin
  thyroid hormone receptor associated protein 3
  thyroid hormone receptor interactor 4
  thyroid hormone receptor interactor 6
  TIA1 cytotoxic granule associated RNA binding protein
  TIA1 cytotoxic granule associated RNA binding protein like 1
  TP53 induced glycolysis regulatory phosphatase
  TP53 regulated inhibitor of apoptosis 1
  transaldolase 1
  transcription elongation regulator 1
  transcription factor 3
  transcription factor Dp-1
  transforming growth factor beta 1
  transketolase
  trinucleotide repeat containing adaptor 6B
  tripartite motif containing 25
  tripartite motif containing 28
  tripartite motif containing 56
  tRNA methyltransferase 1 like
  TruB pseudouridine synthase family member 2
  TSC22 domain family member 4
  Tu translation elongation factor, mitochondrial
  tubulin alpha 4a
  tubulin beta 2A class IIa
  tubulin beta 4B class IVb
  tubulin beta 6 class V
  tubulin beta class I
  tubulin gamma complex associated protein 3
  tumor protein p53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  U2 small nuclear RNA auxiliary factor 2
  U2 snRNP associated SURP domain containing
  ubiquitin conjugating enzyme E2 L6
  ubiquitin conjugating enzyme E2 M
  ubiquitin like 4A
  ubiquitin like 5
  ubiquitin protein ligase E3C
  ubiquitination factor E4A
  UDP-glucose pyrophosphorylase 2
  unk zinc finger
  UPF1 RNA helicase and ATPase
  UPF3B regulator of nonsense mediated mRNA decay
  UTP4 small subunit processome component
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  WD repeat domain 33
  WEE1 G2 checkpoint kinase
  WW domain containing E3 ubiquitin protein ligase 1
  WW domain containing E3 ubiquitin protein ligase 2
  X-ray repair cross complementing 5
  Yes1 associated transcriptional regulator
  YY1 associated factor 2
  zinc finger C2HC-type containing 1A
  zinc finger CCCH-type containing 7A
  zinc finger CCHC-type containing 10
  zinc finger protein 281
  zinc finger protein 384
  zinc finger protein 622
  zinc finger protein 830

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.