PSMA3, proteasome 20S subunit alpha 3

PSMA3, proteasome 20S subunit alpha 3

• The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

• Gene Synonyms (proteasome subunit alpha type-3, macropain subunit C8, multicatalytic endopeptidase complex subunit C8, proteasome (prosome, macropain) subunit, alpha type, 3, proteasome component C8, proteasome subunit C8, proteasome subunit alpha 3, proteasome subunit alpha7, testicular secretory protein Li 43, HC8, PSC3,)
• NCBI Gene ID: 5684
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VK43
  UNIPROT ID#>>P25788
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteasome 20S subunit alpha 3 interacts with:

• 5'-3' exoribonuclease 2
  AAR2 splicing factor
  adaptor related protein complex 3 subunit mu 1
  adhesion G protein-coupled receptor L1
  adhesion regulating molecule 1
  anterior gradient 2, protein disulphide isomerase family member
  apelin
  aurora kinase B
  autophagy and beclin 1 regulator 1
  autophagy related 16 like 1
  BAG cochaperone 3
  beta-transducin repeat containing E3 ubiquitin protein ligase
  butyrophilin subfamily 2 member A2
  C-C motif chemokine ligand 28
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  chloride intracellular channel 4
  chromosome 1 open reading frame 105
  cleavage and polyadenylation specific factor 2
  coiled-coil domain containing 27
  coiled-coil domain containing 69
  crumbs cell polarity complex component 3
  cullin 1
  D-glutamate cyclase
  DNA meiotic recombinase 1
  DNA replication fork stabilization factor DONSON
  doublecortin like kinase 3
  doublesex and mab-3 related transcription factor 3
  elongation factor Tu GTP binding domain containing 2
  elongator acetyltransferase complex subunit 6
  exosome component 4
  exosome component 5
  exosome component 6
  exportin for tRNA
  family with sequence similarity 171 member A2
  family with sequence similarity 83 member A
  F-box and leucine rich repeat protein 18
  F-box and WD repeat domain containing 7
  F-box protein 6
  F-box protein 7
  FKBP prolyl isomerase 8
  FRAT regulator of WNT signaling pathway 1
  glucosidase II alpha subunit
  golgi reassembly stacking protein 2
  growth factor independent 1B transcriptional repressor
  H2B clustered histone 13
  heat shock protein 90 beta family member 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein L like
  HEXIM P-TEFb complex subunit 1
  homeobox A2
  hypoxia up-regulated 1
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  IQ motif containing B1
  IQ motif containing E
  keratin associated protein 19-5
  keratin associated protein 26-1
  keratin associated protein 8-1
  KH-type splicing regulatory protein
  kinase suppressor of ras 1
  kirre like nephrin family adhesion molecule 2
  L3MBTL histone methyl-lysine binding protein 1
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat kinase 2
  limb development membrane protein 1 like
  lon peptidase 1, mitochondrial
  methylphosphate capping enzyme
  negative elongation factor complex member E
  neuraminidase 4
  NHL repeat containing 2
  nuclear receptor coactivator 3
  NUMB like endocytic adaptor protein
  odd-skipped related transciption factor 2
  PAF1 homolog, Paf1/RNA polymerase II complex component
  PAT1 homolog 1, processing body mRNA decay factor
  pleckstrin homology domain containing A4
  poly(U) binding splicing factor 60
  polypyrimidine tract binding protein 1
  PRELI domain containing 3A
  pre-mRNA processing factor 19
  prohibitin 2
  proline rich 13
  proline rich 3
  proline rich coiled-coil 2A
  proteasome (prosome, macropain) subunit, beta type 4
  proteasome (prosome, macropain) subunit, beta type 5
  proteasome 20S subunit alpha 3
  proteasome 20S subunit alpha 4
  proteasome 20S subunit alpha 5
  proteasome 20S subunit alpha 6
  proteasome 20S subunit alpha 7
  proteasome 20S subunit alpha 8
  proteasome 20S subunit beta 1
  proteasome 20S subunit beta 10
  proteasome 20S subunit beta 2
  proteasome 20S subunit beta 3
  proteasome 20S subunit beta 4
  proteasome 20S subunit beta 5
  proteasome 20S subunit beta 6
  proteasome 20S subunit beta 7
  proteasome 20S subunit beta 8
  proteasome 20S subunit beta 9
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 4
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 4
  proteasome 26S subunit, non-ATPase 5
  proteasome 26S subunit, non-ATPase 6
  proteasome 26S subunit, non-ATPase 7
  proteasome 26S subunit, non-ATPase 8
  proteasome activator subunit 1
  proteasome activator subunit 2
  proteasome activator subunit 3
  proteasome activator subunit 4
  proteasome assembly chaperone 2
  proteasome maturation protein
  protein disulfide isomerase family A member 6
  protein phosphatase, Mg2+/Mn2+ dependent 1F
  protein tyrosine phosphatase non-receptor type 2
  protein tyrosine phosphatase non-receptor type 23
  Pro-X-Gly collagen triple helix like repeat containing
  PTTG1 regulator of sister chromatid separation, securin
  PWWP domain containing 2B
  PWWP domain containing 3A, DNA repair factor
  RAB3A interacting protein like 1
  RAD18 E3 ubiquitin protein ligase
  RAD23 homolog A, nucleotide excision repair protein
  RAD23 homolog B, nucleotide excision repair protein
  RAD54 like 2
  RB binding protein 5, histone lysine methyltransferase complex subunit
  receptor transporter protein 5 (putative)
  RecQ like helicase 4
  RFT1 homolog
  ring finger protein 31
  RNA binding fox-1 homolog 2
  RNA binding motif protein 42
  RNA guanine-7 methyltransferase activating subunit
  RuvB like AAA ATPase 1
  sacsin molecular chaperone
  serpin family B member 3
  serrate, RNA effector molecule
  SH3 domain containing GRB2 like, endophilin B2
  SH3 domain containing kinase binding protein 1
  SHANK associated RH domain interactor
  SLAIN motif family member 1
  SLX1 homolog B, structure-specific endonuclease subunit
  small EDRK-rich factor 2
  small nuclear ribonucleoprotein polypeptide C
  small nuclear ribonucleoprotein polypeptide F
  small nuclear ribonucleoprotein polypeptides B and B1
  snail family transcriptional repressor 2
  solute carrier family 22 member 23
  S-phase kinase associated protein 1
  S-phase kinase-associated protein 1
  spliceosome associated factor 3, U4/U6 recycling protein
  splicing factor 1
  splicing factor 3a subunit 3
  splicing factor proline and glutamine rich
  SRSF protein kinase 2
  STIP1 homology and U-box containing protein 1
  stomatin like 2
  stress induced phosphoprotein 1
  synoviolin 1
  syntaxin 11
  syntaxin 1A
  syntaxin 4
  syntaxin 6
  TAR DNA binding protein
  TBC1 domain family member 16
  TBL1X receptor 1
  T-box transcription factor 6
  transcription factor 7 like 2
  transferrin
  transforming growth factor beta receptor 2
  tribbles pseudokinase 3
  triosephosphate isomerase 1
  tripartite motif containing 25
  tryptophanyl-tRNA synthetase 1
  tubulin alpha 1b
  tubulin alpha 1c
  tubulin beta 2A class IIa
  tubulin beta 4B class IVb
  tumor suppressor candidate 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  ubiquilin 4
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  ubiquitin like modifier activating enzyme 2
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 5
  ubiquitin specific peptidase 7
  valosin containing protein
  vascular cell adhesion molecule 1
  vimentin
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  VPS37C subunit of ESCRT-I
  WD repeat domain 48
  WD repeat domain 5
  X-ray repair cross complementing 5
  yippee like 3
  zinc finger AN1-type containing 1
  zinc finger protein 366
  zinc finger protein 385C
  zinc finger protein 688

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.