PSMB2, proteasome 20S subunit beta 2

PSMB2, proteasome 20S subunit beta 2

• The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

• Gene Synonyms (proteasome subunit beta type-2, macropain subunit C7-I, multicatalytic endopeptidase complex subunit C7-1, multicatalytic endopeptidase complex subunit C7-I, proteasome (prosome, macropain) subunit, beta type, 2, proteasome beta 2 subunit, proteasome component C7-I, proteasome subunit beta 2, proteasome subunit beta4, proteasome subunit, beta type, 2, testicular tissue protein Li 152, HC7-I,)
• NCBI Gene ID: 5690
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7Z478
  UNIPROT ID#>>A0A140VJS6
  UNIPROT ID#>>P49721
  UNIPROT ID#>>A0A087WVV1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteasome 20S subunit beta 2 interacts with:

• AAR2 splicing factor
  adhesion regulating molecule 1
  akirin 2
  ankyrin repeat and SOCS box containing 11
  anterior gradient 2, protein disulphide isomerase family member
  autophagy and beclin 1 regulator 1
  axin 2
  chromosome 11 open reading frame 58
  cyclin dependent kinase 20
  DEAD-box helicase 49
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  exportin for tRNA
  F-box protein 7
  FKBP prolyl isomerase 8
  glycogen phosphorylase B
  homeobox A2
  inhibitor of CDK, cyclin A1 interacting protein 1
  IQ motif containing B1
  keratin associated protein 19-1
  keratin associated protein 19-5
  keratin associated protein 19-6
  keratin associated protein 19-7
  kinase suppressor of ras 1
  L3MBTL histone methyl-lysine binding protein 1
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat kinase 2
  limb development membrane protein 1 like
  mitochondrial ribosomal protein S9
  obscurin like cytoskeletal adaptor 1
  phosphatase and tensin homolog
  pirin
  potassium channel tetramerization domain containing 9
  pre-mRNA processing factor 8
  proteasome (prosome, macropain) subunit, beta type 4
  proteasome (prosome, macropain) subunit, beta type 5
  proteasome 20S subunit alpha 8
  proteasome 20S subunit beta 2
  proteasome 20S subunit beta 3
  proteasome 20S subunit beta 4
  proteasome 20S subunit beta 5
  proteasome 20S subunit beta 6
  proteasome 20S subunit beta 7
  proteasome 20S subunit beta 8
  proteasome 20S subunit beta 9
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 4
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 4
  proteasome 26S subunit, non-ATPase 5
  proteasome 26S subunit, non-ATPase 6
  proteasome 26S subunit, non-ATPase 7
  proteasome 26S subunit, non-ATPase 8
  proteasome activator subunit 1
  proteasome activator subunit 2
  proteasome activator subunit 3
  proteasome activator subunit 4
  proteasome assembly chaperone 1
  proteasome assembly chaperone 2
  proteasome inhibitor subunit 1
  proteasome maturation protein
  protein tyrosine phosphatase non-receptor type 2
  pyrroline-5-carboxylate reductase 3
  RAD23 homolog A, nucleotide excision repair protein
  RAD23 homolog B, nucleotide excision repair protein
  receptor interacting serine/threonine kinase 4
  RecQ like helicase 4
  required for meiotic nuclear division 5 homolog A
  Sec23 homolog A, COPII coat complex component
  SHANK associated RH domain interactor
  slingshot protein phosphatase 1
  SLX1 homolog B, structure-specific endonuclease subunit
  S-phase kinase associated protein 1
  S-phase kinase-associated protein 1
  sulfotransferase family 1A member 4
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
  synoviolin 1
  thiosulfate sulfurtransferase
  TNFAIP3 interacting protein 2
  tubulin beta class I
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  ubiquitin A-52 residue ribosomal protein fusion product 1
  ubiquitin C
  ubiquitin conjugating enzyme E2 A
  ubiquitin conjugating enzyme E2 B
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  ubiquitin like domain containing CTD phosphatase 1
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 15
  vascular cell adhesion molecule 1
  vimentin
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.