UBE2M, ubiquitin conjugating enzyme E2 M

UBE2M, ubiquitin conjugating enzyme E2 M

• The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]

• Gene Synonyms (NEDD8-conjugating enzyme Ubc12, NEDD8 carrier protein, NEDD8 protein ligase, epididymis secretory sperm binding protein, ubiquitin carrier protein M, ubiquitin conjugating enzyme E2M, ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast), ubiquitin-protein ligase M, yeast UBC12 homolog, UBC-RS2, UBC12, hUbc12,)
• NCBI Gene ID: 9040
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R4T4
  UNIPROT ID#>>P61081
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin conjugating enzyme E2 M interacts with:

• 5'-nucleotidase, cytosolic IB
  actin related protein 1A
  activator of HSP90 ATPase activity 1
  adhesion G protein-coupled receptor V1
  adhesion regulating molecule 1
  ADP ribosylation factor GTPase activating protein 2
  aminopeptidase puromycin sensitive
  ankyrin repeat and FYVE domain containing 1
  anterior gradient 2, protein disulphide isomerase family member
  ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
  ariadne RBR E3 ubiquitin protein ligase 2
  BAG cochaperone 3
  BAH domain and coiled-coil containing 1
  BICD cargo adaptor 2
  bolA family member 2
  bromodomain containing 8
  BTB domain containing 1
  BTB domain containing 2
  BTB domain containing 9
  carboxymethylenebutenolidase homolog
  carboxypeptidase vitellogenic like
  CD2 cytoplasmic tail binding protein 2
  cell division cycle 37, HSP90 cochaperone
  cereblon
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  checkpoint kinase 2
  coactosin like F-actin binding protein 1
  coiled-coil domain containing 22
  coiled-coil-helix-coiled-coil-helix domain containing 4
  COP9 signalosome subunit 2
  COP9 signalosome subunit 4
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  COP9 signalosome subunit 7A
  COP9 signalosome subunit 7B
  COP9 signalosome subunit 8
  COPI coat complex subunit beta 2
  COPI coat complex subunit epsilon
  COPI coat complex subunit gamma 1
  copine 2
  copine 4
  C-type lectin domain containing 16A
  cullin 7
  cullin associated and neddylation dissociated 1
  cyclase associated actin cytoskeleton regulatory protein 1
  cysteine and histidine rich domain containing 1
  cytoskeleton associated protein 5
  DAZ associated protein 1
  DDB1 and CUL4 associated factor 1
  DDB1 and CUL4 associated factor 11
  DDB1 and CUL4 associated factor 6
  DDB1 and CUL4 associated factor 8
  defective in cullin neddylation 1 domain containing 1
  defective in cullin neddylation 1 domain containing 2
  defective in cullin neddylation 1 domain containing 3
  defective in cullin neddylation 1 domain containing 4
  defective in cullin neddylation 1 domain containing 5
  denticleless E3 ubiquitin protein ligase homolog
  dual specificity phosphatase 23
  dynactin subunit 2
  dynactin subunit 3
  dynactin subunit 6
  elongation factor Tu GTP binding domain containing 2
  endoplasmic reticulum protein 44
  eukaryotic translation initiation factor 3 subunit C like
  eukaryotic translation initiation factor 3 subunit K
  eukaryotic translation initiation factor 3 subunit L
  F-box and leucine rich repeat protein 8
  F-box protein 17
  F-box protein 21
  F-box protein 3
  F-box protein 30
  F-box protein 7
  G3BP stress granule assembly factor 1
  gephyrin
  GrpE like 1, mitochondrial
  heat shock protein family A (Hsp70) member 4 like
  heat shock protein family H (Hsp110) member 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  highly divergent homeobox
  histone deacetylase 6
  histone deacetylase 8
  HIV-1 Tat specific factor 1
  hypoxia up-regulated 1
  influenza virus NS1A binding protein
  inositol-3-phosphate synthase 1
  itchy E3 ubiquitin protein ligase
  kelch domain containing 10
  kelch domain containing 2
  kelch domain containing 3
  kelch like family member 12
  kelch like family member 13
  kelch like family member 18
  kelch like family member 20
  kelch like family member 22
  kelch like family member 24
  kelch like family member 26
  kelch like family member 42
  kelch like family member 9
  kelch repeat and BTB domain containing 6
  kelch repeat and BTB domain containing 7
  KH domain containing 4, pre-mRNA splicing factor
  KH RNA binding domain containing, signal transduction associated 1
  lamin B2
  leucine aminopeptidase 3
  leucine rich pentatricopeptide repeat containing
  LRR binding FLII interacting protein 1
  MCTS1 re-initiation and release factor
  membrane associated ring-CH-type finger 7
  metal response element binding transcription factor 2
  methylphosphate capping enzyme
  microtubule associated protein RP/EB family member 1
  MIS12 kinetochore complex component
  mitochondrial ribosomal protein L39
  MOB kinase activator 1B
  nischarin
  NPR2 like, GATOR1 complex subunit
  nuclear distribution C, dynein complex regulator
  nucleoporin 50
  odr-4 GPCR localization factor homolog
  Parkinsonism associated deglycase
  PC-esterase domain containing 1A
  peroxiredoxin 3
  peroxiredoxin 4
  peroxiredoxin 6
  phosphoglycerate dehydrogenase
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  pleckstrin homology domain containing A4
  poly(U) binding splicing factor 60
  potassium channel tetramerization domain containing 10
  potassium channel tetramerization domain containing 17
  potassium channel tetramerization domain containing 2
  potassium channel tetramerization domain containing 3
  potassium channel tetramerization domain containing 5
  potassium channel tetramerization domain containing 6
  pre-mRNA processing factor 31
  prohibitin 2
  prostaglandin E synthase 3
  proteasome 26S subunit, non-ATPase 6
  protein arginine methyltransferase 5
  protein disulfide isomerase family A member 4
  protein disulfide isomerase family A member 6
  protein phosphatase 4 regulatory subunit 2
  protein phosphatase 4 regulatory subunit 3A
  PTEN induced kinase 1
  quinolinate phosphoribosyltransferase
  RAB guanine nucleotide exchange factor 1
  RAB15, member RAS oncogene family
  RAB1B, member RAS oncogene family
  RAD18 E3 ubiquitin protein ligase
  receptor for activated C kinase 1
  Rho related BTB domain containing 1
  Rho-associated coiled-coil containing protein kinase 1
  ring finger protein 111
  ring finger protein 138
  ring finger protein 213
  ring finger protein 7
  ring-box 1
  RIO kinase 1
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA binding motif protein 8A
  RPTOR independent companion of MTOR complex 2
  RuvB like AAA ATPase 2
  SEC22 homolog B, vesicle trafficking protein
  SEC23 homolog B, COPII coat complex component
  SEC23 interacting protein
  SEC24 homolog B, COPII coat complex component
  SEC24 homolog C, COPII coat complex component
  SEC31 homolog A, COPII coat complex component
  SEH1 like nucleoporin
  serine/threonine kinase 38
  serine/threonine kinase 38 like
  serine/threonine kinase receptor associated protein
  SERPINE1 mRNA binding protein 1
  serrate, RNA effector molecule
  SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
  SH3KBP1 binding protein 1
  SLC9A3 regulator 2
  SMAD specific E3 ubiquitin protein ligase 1
  SMAD specific E3 ubiquitin protein ligase 2
  small nuclear ribonucleoprotein U5 subunit 200
  SNW domain containing 1
  solute carrier family 33 member 1
  sperm associated antigen 9
  spindlin 1
  spindlin interactor and repressor of chromatin binding
  splicing factor 3b subunit 3
  STIP1 homology and U-box containing protein 1
  stress induced phosphoprotein 1
  structural maintenance of chromosomes 2
  structural maintenance of chromosomes 3
  SUMO peptidase family member, NEDD8 specific
  SUMO1 activating enzyme subunit 1
  synaptotagmin binding cytoplasmic RNA interacting protein
  TBL1X receptor 1
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  TGF-beta activated kinase 1 (MAP3K7) binding protein 2
  thioredoxin domain containing 5
  thioredoxin domain containing 9
  THO complex 3
  TNF receptor associated protein 1
  trafficking from ER to golgi regulator
  trafficking protein particle complex 11
  trafficking protein particle complex 13
  trafficking protein particle complex 5
  transforming acidic coiled-coil containing protein 3
  transient receptor potential cation channel subfamily C member 4 associated protein
  tripartite motif containing 28
  tRNA methyltransferase 10C, mitochondrial RNase P subunit
  tubulin alpha 1b
  tubulin alpha like 3
  tubulin beta 4B class IVb
  tubulin beta class I
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 T
  ubiquitin C-terminal hydrolase L5
  ubiquitin like domain containing CTD phosphatase 1
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 15
  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
  UDP-glucose glycoprotein glucosyltransferase 1
  uveal autoantigen with coiled-coil domains and ankyrin repeats
  vacuolar protein sorting 45 homolog
  VPS53 subunit of GARP complex
  WASH complex subunit 2A
  WD repeat domain 77
  zinc finger RANBP2-type containing 2
  zyg-11 family member B, cell cycle regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.