DNAJA1, DnaJ heat shock protein family (Hsp40) member A1

DNAJA1, DnaJ heat shock protein family (Hsp40) member A1

• This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes. [provided by RefSeq, Sep 2015]

• Gene Synonyms (dnaJ homolog subfamily A member 1, DnaJ (Hsp40) homolog, subfamily A, member 1, dnaJ protein homolog 2, heat shock 40 kDa protein 4, heat shock protein J2, heat shock protein, DNAJ-like 2, human DnaJ protein 2, neural precursor cell expressed, developmentally down-regulated 7, DJ-2, DjA1, HDJ2, HSDJ, HSJ-2, HSJ2, HSPF4, NEDD7, hDJ-2,)
• NCBI Gene ID: 3301
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7Z5C0
  UNIPROT ID#>>P31689
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DnaJ heat shock protein family (Hsp40) member A1 interacts with:

• AAR2 splicing factor
  activator of HSP90 ATPase activity 1
  AKT interacting protein
  aminoacyl tRNA synthetase complex interacting multifunctional protein 1
  ankyrin repeat and SOCS box containing 5
  apoptosis associated tyrosine kinase
  apoptosis inducing factor mitochondria associated 1
  arginyl-tRNA synthetase 1
  argonaute RISC catalytic component 3
  argonaute RISC component 4
  ataxin 3
  autophagy related 16 like 1
  BCL2-associated X protein
  bromodomain containing 7
  CDK5 regulatory subunit associated protein 2
  cell division cycle 16
  cell division cycle 73
  centrosomal protein 44
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 6B
  clusterin associated protein 1
  COP9 signalosome subunit 5
  cullin 1
  cullin 2
  cullin 3
  cullin 4B
  cullin 5
  cullin 7
  cyclin J like
  DISC1 scaffold protein
  DnaJ heat shock protein family (Hsp40) member A1
  DnaJ heat shock protein family (Hsp40) member A4
  dynamin 1 like
  EEF1A lysine methyltransferase 3
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  EP300 interacting inhibitor of differentiation 1
  eukaryotic translation elongation factor 1 epsilon 1
  Fas associated factor 1
  F-box protein 25
  F-box protein 6
  F-box protein 7
  FERM domain containing 5
  fibrillarin
  fizzy and cell division cycle 20 related 1
  G3BP stress granule assembly factor 1
  GLIS family zinc finger 3
  glutamate rich WD repeat containing 1
  glutaminyl-tRNA synthetase 1
  H2A clustered histone 4
  H4 clustered histone 1
  heat shock protein 90 alpha family class A member 1
  heat shock protein family A (Hsp70) member 1A
  heat shock protein family A (Hsp70) member 4
  heat shock protein family A (Hsp70) member 4 like
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 6
  heat shock protein family A (Hsp70) member 8
  heat shock protein family A (Hsp70) member 9
  heat shock protein family H (Hsp110) member 1
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  heparanase
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 10
  histone deacetylase 11
  histone deacetylase 5
  histone deacetylase 6
  hypoxia inducible factor 1 subunit alpha inhibitor
  hypoxia up-regulated 1
  integrin alpha FG-GAP repeat containing 1
  integrin linked kinase
  interleukin 1 receptor associated kinase 1
  IQ motif containing B1
  IQ motif containing GTPase activating protein 1
  karyopherin subunit alpha 4
  kinase suppressor of ras 1
  lactate dehydrogenase B
  leucine rich repeat kinase 1
  leucine rich repeat kinase 2
  LIM domain kinase 2
  limb development membrane protein 1 like
  LLGL scribble cell polarity complex component 2
  LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
  lysine demethylase 6B
  MAD2 mitotic arrest deficient-like 1
  mediator complex subunit 12
  methyltransferase like 14
  methyltransferase like 23
  methyltransferase like 3
  microtubule associated protein tau
  minichromosome maintenance complex component 2
  mitogen-activated protein kinase 6
  MKS transition zone complex subunit 1
  MYC proto-oncogene, bHLH transcription factor
  myotubularin related protein 11
  negative elongation factor complex member C/D
  neurofibromin 2
  neurotrophic receptor tyrosine kinase 1
  nitric oxide synthase 2
  nuclear distribution C, dynein complex regulator
  nuclear factor of activated T cells 2
  nuclear transcription factor, X-box binding 1
  nucleophosmin 1
  nucleotide binding oligomerization domain containing 2
  nudix hydrolase 3
  obscurin like cytoskeletal adaptor 1
  OFD1 centriole and centriolar satellite protein
  O-sialoglycoprotein endopeptidase
  OTU deubiquitinase with linear linkage specificity like
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  oxysterol binding protein like 11
  oxysterol binding protein like 9
  palmitoyl-protein thioesterase 1
  parkin coregulated
  parkin RBR E3 ubiquitin protein ligase
  PAX interacting protein 1
  peroxisome proliferator activated receptor gamma
  phosphatase and tensin homolog
  phosphoenolpyruvate carboxykinase 1
  phospholipase D2
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  poly(A) specific ribonuclease subunit PAN2
  potassium voltage-gated channel subfamily H member 2
  potassium voltage-gated channel subfamily Q member 4
  pre-mRNA processing factor 8
  presenilin 1
  progesterone receptor
  prohibitin
  proprotein convertase subtilisin/kexin type 9
  prosaposin
  proteasome 20S subunit alpha 3
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 11
  protein inhibitor of activated STAT 1
  protein kinase C substrate 80K-H
  protein phosphatase 1 catalytic subunit gamma
  protein phosphatase 2 regulatory subunit Bgamma
  protein phosphatase 4 regulatory subunit 2
  protein phosphatase with EF-hand domain 1
  PTTG1 regulator of sister chromatid separation, securin
  pyrimidinergic receptor P2Y6
  pyruvate dehydrogenase E1 subunit alpha 1
  Raf-1 proto-oncogene, serine/threonine kinase
  receptor interacting serine/threonine kinase 4
  RecQ like helicase 4
  retinitis pigmentosa GTPase regulator
  ribosomal protein lateral stalk subunit P0
  ribosomal protein S6 kinase B2
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 123
  ring finger protein 207
  ring finger protein 31
  ring-box 1
  RIO kinase 1
  serine and arginine repetitive matrix 1
  serine/arginine repetitive matrix 2
  serine/threonine kinase 40
  SET domain containing 1A, histone lysine methyltransferase
  SHC adaptor protein 1
  sideroflexin 1
  sirtuin 7
  small nuclear ribonucleoprotein U1 subunit 70
  small ubiquitin like modifier 4
  snail family transcriptional repressor 1
  SNW domain containing 1
  spectrin alpha, non-erythrocytic 1
  SRY-box transcription factor 2
  staufen double-stranded RNA binding protein 1
  STIL centriolar assembly protein
  SUZ12 polycomb repressive complex 2 subunit
  testin LIM domain protein
  thioredoxin
  thymopoietin
  TNFAIP3 interacting protein 2
  transformer 2 beta homolog
  transforming growth factor beta 1
  transmembrane 4 L six family member 1
  transmembrane protein 41B
  tripartite motif containing 25
  tripartite motif containing 28
  tubulin alpha 1a
  tubulin alpha 1c
  tubulin, alpha 1B
  tubulin, alpha 3A
  tubulin, beta 4B class IVB
  tubulin, beta 5 class I
  tubulin, gamma 1
  tumor necrosis factor
  tumor protein p53
  tumor protein, translationally-controlled 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  ubiquilin 2
  ubiquinol-cytochrome c reductase complex III subunit VII
  ubiquinol-cytochrome c reductase core protein 1
  ubiquitin associated and SH3 domain containing B
  ubiquitin C
  ubiquitin conjugating enzyme E2 A
  ubiquitin conjugating enzyme E2 M
  ubiquitin specific peptidase 14
  USO1 vesicle transport factor
  vir like m6A methyltransferase associated
  von Hippel-Lindau tumor suppressor
  WD repeat domain 76
  WW domain containing E3 ubiquitin protein ligase 2
  X-ray repair cross complementing 3
  zinc finger and BTB domain containing 38
  zinc finger containing ubiquitin peptidase 1
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.