RPN2, ribophorin II

RPN2, ribophorin II

• This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

• Gene Synonyms (dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2, dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit, oligosaccharyltransferase complex subunit (non-catalytic), ribophorin-2, RIBIIR, RPN-II, RPNII, SWP1,)
• NCBI Gene ID: 6185
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P04844
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ribophorin II interacts with:

• 3-hydroxyacyl-CoA dehydratase 1
  adhesion regulating molecule 1
  ALG8 alpha-1,3-glucosyltransferase
  anterior gradient 2, protein disulphide isomerase family member
  ATPase, Cu++ transporting, alpha polypeptide
  Bet1 golgi vesicular membrane trafficking protein
  BRISC and BRCA1 A complex member 2
  bromodomain containing 7
  CCCTC-binding factor
  cell division cycle 73
  cullin 3
  cullin 7
  derlin 2
  desmoglein 4
  DExD-box helicase 39B
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  ER degradation enhancing alpha-mannosidase like protein 3
  eukaryotic translation initiation factor 2 alpha kinase 3
  family with sequence similarity 241 member A
  Fas associated factor 1
  F-box and WD repeat domain containing 7
  F-box protein 25
  F-box protein 6
  fibrillin 3
  glutathione S-transferase kappa 1
  H4 clustered histone 1
  heat shock protein 90 beta family member 1
  hephaestin like 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 5
  importin 9
  integrin alpha FG-GAP repeat containing 1
  jun B proto-oncogene
  leucine rich repeat containing 15
  limb development membrane protein 1 like
  lin-54 DREAM MuvB core complex component
  lin-9 DREAM MuvB core complex component
  lysozyme g2
  malectin
  metaxin 2
  methylphosphate capping enzyme
  methyltransferase like 14
  MMS19 homolog, cytosolic iron-sulfur assembly component
  nicalin
  N-myc downstream regulated 1
  nuclear receptor subfamily 2 group C member 2
  ORMDL sphingolipid biosynthesis regulator 2
  pleckstrin homology domain containing A4
  proteasome 26S subunit, non-ATPase 14
  protein tyrosine phosphatase non-receptor type 5
  PTEN induced kinase 1
  RAB1B, member RAS oncogene family
  RAB7A, member RAS oncogene family
  RecQ like helicase 4
  retinol dehydrogenase 13
  ring finger and CHY zinc finger domain containing 1
  ring finger protein 185
  signal sequence receptor subunit 4
  Sin3A associated protein 18
  sirtuin 7
  solute carrier family 15 member 3
  solute carrier family 25 member 1
  spectrin alpha, non-erythrocytic 1
  sphingomyelin phosphodiesterase 2
  sterol O-acyltransferase 1
  STT3 oligosaccharyltransferase complex catalytic subunit B
  succinate dehydrogenase complex flavoprotein subunit A
  tectonic family member 1
  tectonic family member 2
  tectonic family member 3
  testis expressed 101
  transcription factor 3
  transcription factor CP2
  transforming acidic coiled-coil containing protein 1
  trans-golgi network protein 2
  translocase of outer mitochondrial membrane 22
  translocase of outer mitochondrial membrane 40
  translocase of outer mitochondrial membrane 5
  translocase of outer mitochondrial membrane 6
  transmembrane 9 superfamily member 2
  transmembrane 9 superfamily member 4
  transmembrane BAX inhibitor motif containing 4
  transmembrane p24 trafficking protein 2
  transmembrane protein 109
  transmembrane protein 41B
  tripartite motif containing 14
  tumor suppressor candidate 3
  UBA domain containing 2
  ubiquinol-cytochrome c reductase core protein 2
  ubiquitin like 4A
  unc-93 homolog B1, TLR signaling regulator
  valosin containing protein
  VAMP associated protein A
  VAMP associated protein B and C
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  voltage dependent anion channel 2
  voltage dependent anion channel 3
  V-set and immunoglobulin domain containing 8
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  Yes1 associated transcriptional regulator
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.