XRCC5, X-ray repair cross complementing 5

XRCC5, X-ray repair cross complementing 5

• The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

• Gene Synonyms (X-ray repair cross-complementing protein 5, 86 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 80 kDa subunit, CTC box-binding factor 85 kDa subunit, CTC85, CTCBF, DNA repair protein XRCC5, Ku autoantigen, 80kDa, Ku86 autoantigen related protein 1, TLAA, X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining), lupus Ku autoantigen protein p86, nuclear factor IV, thyroid-lupus autoantigen, KARP-1, KARP1, KU80, KUB2, Ku86, NFIV,)
• NCBI Gene ID: 7520
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P13010
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

X-ray repair cross complementing 5 interacts with:

• activator of HSP90 ATPase activity 1
  anoctamin 7
  anterior gradient 2, protein disulphide isomerase family member
  aprataxin and PNKP like factor
  ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
  autophagy related 16 like 1
  bromodomain adjacent to zinc finger domain 1A
  bromodomain and PHD finger containing 1
  bromodomain containing 7
  cap methyltransferase 1
  CDK5 regulatory subunit associated protein 1
  cell division cycle 16
  centrosomal protein 128
  checkpoint kinase 2
  chromatin accessibility complex subunit 1
  chromatin assembly factor 1 subunit A
  chromodomain helicase DNA binding protein 1 like
  chromosome 17 open reading frame 49
  coiled-coil domain containing 8
  coilin
  cold shock domain containing E1
  cullin 2
  cullin 3
  cullin 7
  DEAD-box helicase 17
  decapping enzyme, scavenger
  derlin 1
  DNA cross-link repair 1C
  DNA polymerase epsilon 3, accessory subunit
  dynamin 1 like
  dynamin binding protein
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  ETS homologous factor
  eukaryotic translation initiation factor 3 subunit J
  F-box and leucine-rich repeat protein 16
  glucosidase II alpha subunit
  golgin A5
  H2A clustered histone 4
  H3 clustered histone 1
  H3 clustered histone 6
  H4 clustered histone 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 5
  histone deacetylase 6
  hypoxia up-regulated 1
  immunoglobulin superfamily member 8
  integrin alpha FG-GAP repeat containing 1
  ISG15 ubiquitin like modifier
  La ribonucleoprotein 7, transcriptional regulator
  lamin B2
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
  leucine rich repeats and WD repeat domain containing 1
  lysine demethylase 2B
  macroH2A.1 histone
  mediator of DNA damage checkpoint 1
  methylphosphate capping enzyme
  methyltransferase like 14
  microtubule associated serine/threonine kinase 3
  microtubule interacting and trafficking domain containing 1
  mindbomb E3 ubiquitin protein ligase 2
  mitogen-activated protein kinase kinase kinase 6
  mono-ADP ribosylhydrolase 1
  multiple PDZ domain crumbs cell polarity complex component
  N-alpha-acetyltransferase 15, NatA auxiliary subunit
  Nanog homeobox
  N-myc downstream regulated 1
  non-homologous end joining factor 1
  nuclear receptor coactivator 3
  nuclear receptor coactivator 6
  nuclear receptor subfamily 1 group H member 4
  obscurin like cytoskeletal adaptor 1
  origin recognition complex subunit 3
  origin recognition complex subunit 6
  PAF1 homolog, Paf1/RNA polymerase II complex component
  pellino E3 ubiquitin protein ligase 1
  peptidylprolyl isomerase E
  PHD and ring finger domains 1
  phosphotriesterase related
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  pleckstrin homology domain interacting protein
  polycomb group ring finger 1
  polynucleotide kinase 3'-phosphatase
  PR/SET domain 16
  pre-mRNA processing factor 8
  protein arginine methyltransferase 3
  pseudopodium enriched atypical kinase 1
  RecQ like helicase 4
  regulator of telomere elongation helicase 1
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 123
  ring finger protein 126
  ring finger protein 126
  ring finger protein 146
  ring finger protein 31
  ring finger protein 8
  RNA binding motif protein 14
  RNA binding motif protein 39
  SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
  shugoshin 1
  sirtuin 6
  sirtuin 7
  SMAD specific E3 ubiquitin protein ligase 1
  SMYD family member 5
  snurportin 1
  splicing factor 1
  SPT16 homolog, facilitates chromatin remodeling subunit
  SUMO specific peptidase 3
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  TAR DNA binding protein
  TERF2 interacting protein
  testis expressed 101
  TNFAIP3 interacting protein 2
  transformed mouse 3T3 cell double minute 2
  tripartite motif containing 25
  tRNA methyltransferase 1
  tyrosyl-tRNA synthetase 1
  ubiquilin 2
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 S
  ubiquitin like with PHD and ring finger domains 1
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin specific peptidase 11
  UV radiation resistance associated gene
  vir like m6A methyltransferase associated
  VRK serine/threonine kinase 3
  WD repeat domain 76
  WW domain containing E3 ubiquitin protein ligase 1
  WW domain containing E3 ubiquitin protein ligase 2
  X-ray repair cross complementing 5
  Yes1 associated transcriptional regulator
  YY1 associated factor 2
  YY1 transcription factor
  zinc finger and BTB domain containing 38
  zinc finger and BTB domain containing 7A
  zinc finger protein 746
  zinc finger RANBP2-type containing 1
  zinc finger ZZ-type and EF-hand domain containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.