PSMA5, proteasome 20S subunit alpha 5

PSMA5, proteasome 20S subunit alpha 5

• The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

• Gene Synonyms (proteasome subunit alpha type-5, epididymis tissue sperm binding protein Li 11n, macropain subunit zeta, macropain zeta chain, multicatalytic endopeptidase complex zeta chain, proteasome (prosome, macropain) subunit, alpha type, 5, proteasome alpha 5 subunit, proteasome component 5, proteasome subunit alpha 5, proteasome subunit zeta, proteasome zeta chain, PSC5, ZETA,)
• NCBI Gene ID: 5686
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A109NGN6
  UNIPROT ID#>>P28066
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteasome 20S subunit alpha 5 interacts with:

• AAR2 splicing factor
  adhesion regulating molecule 1
  anterior gradient 2, protein disulphide isomerase family member
  ATP binding cassette subfamily E member 1
  aurora kinase A
  autophagy and beclin 1 regulator 1
  BAG cochaperone 3
  chaperonin containing TCP1 subunit 3
  chloride intracellular channel 4
  cullin 1
  cullin 3
  cullin 7
  cullin associated and neddylation dissociated 1
  DEAD-box helicase 23
  desumoylating isopeptidase 1
  dynactin subunit 2
  Ecm29 proteasome adaptor and scaffold
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  exosome component 4
  exosome component 5
  exosome component 6
  F-box protein 7
  FKBP prolyl isomerase 8
  forkhead box P3
  forkhead box R2
  HEAT repeat containing 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  histone deacetylase 5
  inner membrane protein, mitochondrial
  interferon induced transmembrane protein 3
  IQ motif containing B1
  kinase suppressor of ras 1
  L3MBTL histone methyl-lysine binding protein 1
  L3MBTL histone methyl-lysine binding protein 4
  mesoderm development LRP chaperone
  methylphosphate capping enzyme
  mitochondrial ribosomal protein S16
  mitochondrial ribosomal protein S7
  mitochondrial ribosomal protein S9
  MT-RNR2 like 1
  negative elongation factor complex member E
  neuralized E3 ubiquitin protein ligase 4
  NHL repeat containing 2
  peroxisomal biogenesis factor 19
  platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
  pleckstrin homology domain containing A4
  proteasome (prosome, macropain) subunit, beta type 4
  proteasome (prosome, macropain) subunit, beta type 5
  proteasome 20S subunit alpha 5
  proteasome 20S subunit alpha 6
  proteasome 20S subunit alpha 7
  proteasome 20S subunit alpha 8
  proteasome 20S subunit beta 1
  proteasome 20S subunit beta 2
  proteasome 20S subunit beta 3
  proteasome 20S subunit beta 4
  proteasome 20S subunit beta 5
  proteasome 20S subunit beta 6
  proteasome 20S subunit beta 7
  proteasome 20S subunit beta 8
  proteasome 20S subunit beta 9
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 4
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 4
  proteasome 26S subunit, non-ATPase 5
  proteasome 26S subunit, non-ATPase 6
  proteasome 26S subunit, non-ATPase 7
  proteasome 26S subunit, non-ATPase 8
  proteasome activator subunit 2
  proteasome activator subunit 3
  proteasome activator subunit 4
  proteasome assembly chaperone 1
  proteasome assembly chaperone 2
  proteasome assembly chaperone 3
  proteasome maturation protein
  protein tyrosine phosphatase non-receptor type 2
  RAD23 homolog A, nucleotide excision repair protein
  RecQ like helicase 4
  ribonuclease P/MRP subunit p38
  ring finger protein 185
  ring finger protein 4
  S100 calcium binding protein A9
  SEC24 homolog C, COPII coat complex component
  serine and arginine rich splicing factor 2
  SH3 domain binding glutamate rich protein like
  SLX1 homolog B, structure-specific endonuclease subunit
  small nuclear ribonucleoprotein polypeptide A'
  S-phase kinase associated protein 1
  spliceosome associated factor 3, U4/U6 recycling protein
  splicing factor 3a subunit 1
  sulfiredoxin 1
  synapse associated protein 1
  synoviolin 1
  testis expressed 101
  thioredoxin interacting protein
  thymidylate synthetase
  tight junction protein 1
  TNFAIP3 interacting protein 2
  tripartite motif containing 25
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  U2 small nuclear RNA auxiliary factor 2
  ubiquilin 1
  ubiquilin 2
  ubiquilin 4
  ubiquitin C
  ubiquitin conjugating enzyme E2 C
  ubiquitin conjugating enzyme E2 L3
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  ubiquitin like modifier activating enzyme 2
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 7
  vascular cell adhesion molecule 1
  vasodilator stimulated phosphoprotein
  vir like m6A methyltransferase associated
  wolframin ER transmembrane glycoprotein
  X-box binding protein 1
  Yes1 associated transcriptional regulator
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.