PSMA7, proteasome 20S subunit alpha 7

PSMA7, proteasome 20S subunit alpha 7

• The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012]

• Gene Synonyms (proteasome subunit alpha type-7, epididymis secretory protein Li 276, proteasome (prosome, macropain) subunit, alpha type, 7, proteasome subunit RC6-1, proteasome subunit XAPC7, proteasome subunit alpha 4, proteasome subunit alpha 7, testicular tissue protein Li 151, C6, HEL-S-276, HSPC, RC6-1, XAPC7,)
• NCBI Gene ID: 5688
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0K0K1K4
  UNIPROT ID#>>O14818
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteasome 20S subunit alpha 7 interacts with:

• AAR2 splicing factor
  adaptor related protein complex 3 subunit mu 1
  adhesion regulating molecule 1
  aminoacyl tRNA synthetase complex interacting multifunctional protein 1
  anterior gradient 2, protein disulphide isomerase family member
  autophagy and beclin 1 regulator 1
  BAG cochaperone 3
  calpain 10
  centrosomal protein 85
  COP9 signalosome subunit 5
  cullin 1
  cullin 3
  desumoylating isopeptidase 1
  Ecm29 proteasome adaptor and scaffold
  elongation factor Tu GTP binding domain containing 2
  endothelial cell surface expressed chemotaxis and apoptosis regulator
  EPM2A interacting protein 1
  ERBB receptor feedback inhibitor 1
  F-box protein 7
  FKBP prolyl isomerase 8
  golgi brefeldin A resistant guanine nucleotide exchange factor 1
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  inhibitor of nuclear factor kappa B kinase subunit epsilon
  insulin induced gene 2
  IQ motif containing B1
  ISG15 ubiquitin like modifier
  L3MBTL histone methyl-lysine binding protein 1
  L3MBTL histone methyl-lysine binding protein 4
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat kinase 2
  methylphosphate capping enzyme
  mitochondrial antiviral signaling protein
  mitochondrial ribosomal protein S16
  NHL repeat containing 2
  nucleotide binding oligomerization domain containing 1
  obscurin like cytoskeletal adaptor 1
  patched 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  proteasome (prosome, macropain) subunit, beta type 4
  proteasome (prosome, macropain) subunit, beta type 5
  proteasome 20S subunit alpha 7
  proteasome 20S subunit alpha 8
  proteasome 20S subunit beta 1
  proteasome 20S subunit beta 2
  proteasome 20S subunit beta 3
  proteasome 20S subunit beta 4
  proteasome 20S subunit beta 5
  proteasome 20S subunit beta 6
  proteasome 20S subunit beta 7
  proteasome 20S subunit beta 8
  proteasome 20S subunit beta 9
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 4
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 4
  proteasome 26S subunit, non-ATPase 5
  proteasome 26S subunit, non-ATPase 6
  proteasome 26S subunit, non-ATPase 7
  proteasome 26S subunit, non-ATPase 8
  proteasome activator subunit 1
  proteasome activator subunit 3
  proteasome activator subunit 4
  proteasome assembly chaperone 1
  proteasome assembly chaperone 3
  proteasome inhibitor subunit 1
  proteasome maturation protein
  PTEN induced kinase 1
  pyrroline-5-carboxylate reductase 3
  RAB7A, member RAS oncogene family
  RAD23 homolog A, nucleotide excision repair protein
  RB transcriptional corepressor 1
  RecQ like helicase 4
  required for meiotic nuclear division 5 homolog B
  ring finger protein 185
  RNA binding motif protein 3
  SEM1 26S proteasome complex subunit
  SHANK associated RH domain interactor
  SLX1 homolog B, structure-specific endonuclease subunit
  small nuclear ribonucleoprotein polypeptide A'
  spectrin beta, non-erythrocytic 1
  S-phase kinase associated protein 1
  sterile alpha motif domain containing 1
  synoviolin 1
  telomeric repeat binding factor 1
  thromboxane A2 receptor
  TIAM Rac1 associated GEF 1
  TIMP metallopeptidase inhibitor 2
  TNFAIP3 interacting protein 2
  TSC22 domain family member 2
  ubiquilin 1
  ubiquilin 4
  ubiquitin C
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 14
  valosin containing protein
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  YOD1 deubiquitinase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.