UBE2D1, ubiquitin conjugating enzyme E2 D1

UBE2D1, ubiquitin conjugating enzyme E2 D1

• The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

• Gene Synonyms (ubiquitin-conjugating enzyme E2 D1, (E3-independent) E2 ubiquitin-conjugating enzyme D1, E2 ubiquitin-conjugating enzyme D1, UBC4/5 homolog, stimulator of Fe transport, ubiquitin carrier protein D1, ubiquitin conjugating enzyme E2D 1, ubiquitin-conjugating enzyme E2(17)KB 1, ubiquitin-conjugating enzyme E2-17 kDa 1, ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast), ubiquitin-protein ligase D1, E2(17)KB1, SFT, UBC4/5, UBCH5, UBCH5A,)
• NCBI Gene ID: 7321
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024QZJ2
  UNIPROT ID#>>A0A087WW00
  UNIPROT ID#>>P51668
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin conjugating enzyme E2 D1 interacts with:

• adenosylhomocysteinase like 1
  anaphase promoting complex subunit 11
  anaphase promoting complex subunit 11
  ankyrin repeat and SOCS box containing 2
  ankyrin repeat and SOCS box containing 4
  ankyrin repeat and SOCS box containing 9
  apoptosis resistant E3 ubiquitin protein ligase 1
  ariadne RBR E3 ubiquitin protein ligase 1
  ariadne RBR E3 ubiquitin protein ligase 2
  arrestin domain containing 3
  ATPase H+ transporting V1 subunit F
  baculoviral IAP repeat containing 6
  baculoviral IAP repeat containing 7
  beta-transducin repeat containing E3 ubiquitin protein ligase
  bifunctional apoptosis regulator
  BRCA1/BRCA2-containing complex subunit 3
  BRISC and BRCA1 A complex member 2
  BRMS1 transcriptional repressor and anoikis regulator
  calcium dependent secretion activator 2
  canopy FGF signaling regulator 2
  Cbl proto-oncogene C
  cereblon
  checkpoint with forkhead and ring finger domains
  chromosome 7 open reading frame 25
  COP1 E3 ubiquitin ligase
  cullin 2
  cullin 3
  cullin associated and neddylation dissociated 1
  cullin associated and neddylation dissociated 2 (putative)
  DAZ interacting zinc finger protein 3
  deltex E3 ubiquitin ligase 2
  deltex E3 ubiquitin ligase 3
  deltex E3 ubiquitin ligase 3L
  denticleless E3 ubiquitin protein ligase homolog
  DExD/H-box helicase 58
  DNA polymerase lambda
  DNA polymerase mu
  dual specificity tyrosine phosphorylation regulated kinase 2
  Fas associated factor family member 2
  F-box and leucine rich repeat protein 2
  F-box and WD-40 domain protein 15
  F-box protein 2
  F-box protein 7
  fizzy and cell division cycle 20 related 1
  H3 clustered histone 1
  H4 clustered histone 1
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HECT and RLD domain containing E3 ubiquitin protein ligase 3
  HECT and RLD domain containing E3 ubiquitin protein ligase 5
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  histone deacetylase 6
  itchy E3 ubiquitin protein ligase
  kelch like family member 13
  kelch like family member 2
  kelch like family member 9
  leucine rich repeat and sterile alpha motif containing 1
  leucine rich repeat protein 1
  listerin E3 ubiquitin protein ligase 1
  lunapark, ER junction formation factor
  lysine acetyltransferase 2B
  lysine demethylase 2B
  mahogunin ring finger 1
  makorin ring finger protein 1
  makorin ring finger protein 2
  makorin ring finger protein 3
  MAPK interacting serine/threonine kinase 1
  membrane associated ring-CH-type finger 1
  membrane associated ring-CH-type finger 2
  membrane associated ring-CH-type finger 4
  membrane associated ring-CH-type finger 5
  membrane associated ring-CH-type finger 7
  membrane associated ring-CH-type finger 8
  midline 2
  mindbomb E3 ubiquitin protein ligase 1
  mitochondrial E3 ubiquitin protein ligase 1
  myosin regulatory light chain interacting protein
  NEDD4 like E3 ubiquitin protein ligase
  neural precursor cell expressed, developmentally down-regulated 4
  neural precursor cell expressed, developmentally down-regulated gene 4-like
  neuralized E3 ubiquitin protein ligase 1
  NHL repeat containing E3 ubiquitin protein ligase 1
  nuclear receptor subfamily 1 group H member 2
  ORC ubiquitin ligase 1
  OTU deubiquitinase with linear linkage specificity
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  pellino E3 ubiquitin protein ligase 1
  period circadian regulator 2
  potassium channel tetramerization domain containing 17
  praja ring finger ubiquitin ligase 2
  RAB guanine nucleotide exchange factor 1
  RANBP2-type and C3HC4-type zinc finger containing 1
  recombination activating 1
  required for meiotic nuclear division 5 homolog A
  ring finger and CHY zinc finger domain containing 1
  ring finger and FYVE like domain containing E3 ubiquitin protein ligase
  ring finger and WD repeat domain 3
  ring finger protein 10
  ring finger protein 103
  ring finger protein 11
  ring finger protein 111
  ring finger protein 112
  ring finger protein 114
  ring finger protein 115
  ring finger protein 122
  ring finger protein 123
  ring finger protein 125
  ring finger protein 126
  ring finger protein 128
  ring finger protein 13
  ring finger protein 130
  ring finger protein 14
  ring finger protein 144A
  ring finger protein 146
  ring finger protein 150
  ring finger protein 165
  ring finger protein 166
  ring finger protein 167
  ring finger protein 168
  ring finger protein 181
  ring finger protein 182
  ring finger protein 185
  ring finger protein 216
  ring finger protein 25
  ring finger protein 26
  ring finger protein 31
  ring finger protein 38
  ring finger protein 43
  ring finger protein 7
  ring finger protein 8
  ring finger protein, LIM domain interacting
  ring-box 1
  ring-box 1
  SH3 domain binding glutamate rich protein like 2
  SH3 domain containing ring finger 1
  signal transducer and activator of transcription 5A
  signal transducing adaptor molecule 2
  sirtuin 6
  SIVA1 apoptosis inducing factor
  SMAD specific E3 ubiquitin protein ligase 1
  SMAD specific E3 ubiquitin protein ligase 2
  SNF2 histone linker PHD RING helicase
  speckle type BTB/POZ protein
  S-phase kinase-associated protein 1
  STIP1 homology and U-box containing protein 1
  STIP1 homology and U-Box containing protein 1
  target of myb1 membrane trafficking protein
  TATA-box binding protein associated factor, RNA polymerase I subunit D
  TBL1X receptor 1
  thyroid hormone receptor interactor 12
  TNF receptor associated factor 4
  TNF receptor associated factor 7
  TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
  TRAF interacting protein
  transmembrane protein 129, E3 ubiquitin ligase
  tripartite motif containing 10
  tripartite motif containing 11
  tripartite motif containing 17
  tripartite motif containing 2
  tripartite motif containing 25
  tripartite motif containing 26
  tripartite motif containing 28
  tripartite motif containing 3
  tripartite motif containing 31
  tripartite motif containing 32
  tripartite motif containing 35
  tripartite motif containing 38
  tripartite motif containing 39
  tripartite motif containing 43
  tripartite motif containing 45
  tripartite motif containing 5
  tripartite motif containing 50
  tripartite motif containing 54
  tripartite motif containing 55
  tripartite motif containing 62
  tripartite motif containing 63
  tripartite motif containing 69
  tripartite motif containing 7
  tripartite motif containing 8
  tripartite motif-containing 56
  TSC22 domain family member 1
  tubulin tyrosine ligase like 12
  U box domain containing 5
  ubiquilin 1
  ubiquitin associated and SH3 domain containing B
  ubiquitin conjugating enzyme E2 D1
  ubiquitin conjugating enzyme E2 D2
  ubiquitin domain containing 1
  ubiquitin fold modifier 1
  ubiquitin like 7
  ubiquitin like modifier activating enzyme 6
  ubiquitin like with PHD and ring finger domains 1
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin protein ligase E3 component n-recognin 1
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin protein ligase E3A
  ubiquitin protein ligase E3C
  ubiquitin specific peptidase 34
  ubiquitin specific peptidase 9 X-linked
  ubiquitination factor E4A
  ubiquitination factor E4B
  ubiquitin-like, containing PHD and RING finger domains, 1
  U-box domain containing 5
  UBX domain protein 7
  unk zinc finger
  uridine phosphorylase 1
  utrophin
  UV stimulated scaffold protein A
  valosin containing protein
  von Hippel-Lindau tumor suppressor
  WD repeat domain 1
  WD repeat domain 4
  WW domain containing E3 ubiquitin protein ligase 1
  WW domain containing E3 ubiquitin protein ligase 2
  Yes1 associated transcriptional regulator
  zinc and ring finger 1
  zinc and ring finger 2
  zinc and ring finger 4
  zinc finger FYVE-type containing 19
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger SWIM-type containing 2
  zinc ribbon domain containing 2
  ZPR1 zinc finger

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.