UBE2I, ubiquitin conjugating enzyme E2 I

UBE2I, ubiquitin conjugating enzyme E2 I

• The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (SUMO-conjugating enzyme UBC9, RING-type E3 SUMO transferase UBC9, SUMO-1-protein ligase, SUMO-protein ligase, ubiquitin carrier protein 9, ubiquitin carrier protein I, ubiquitin conjugating enzyme 9, ubiquitin conjugating enzyme E2I, ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast), ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9), ubiquitin-conjugating enzyme UbcE2A, ubiquitin-like protein SUMO-1 conjugating enzyme, ubiquitin-protein ligase E2I, ubiquitin-protein ligase I, C358B7.1, P18, UBC9,)
• NCBI Gene ID: 7329
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B0QYN7
  UNIPROT ID#>>P63279
  UNIPROT ID#>>A8K503
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin conjugating enzyme E2 I interacts with:

• activating transcription factor 7 interacting protein
  ADP ribosylation factor GTPase activating protein 2
  ADP ribosylation factor like GTPase 13B
  ADP ribosylation factor like GTPase 6 interacting protein 1
  A-kinase anchoring protein 17A
  aladin WD repeat nucleoporin
  Aly/REF export factor
  anaphase promoting complex subunit 4
  angiotensin II receptor associated protein
  anterior gradient 2, protein disulphide isomerase family member
  aurora kinase B
  baculoviral IAP repeat containing 7
  BAF chromatin remodeling complex subunit BCL11A
  basic helix-loop-helix family member e40
  BEN domain containing 5
  BTB domain containing 3
  BTG3 associated nuclear protein
  calcyclin binding protein
  calmodulin regulated spectrin associated protein family member 2
  caspase 8 associated protein 2
  caspase recruitment domain family member 9
  Cbl proto-oncogene C
  CD2 associated protein
  CDK2 associated cullin domain 1
  cell division cycle 37, HSP90 cochaperone
  cell division cycle associated 8
  cerebellar degeneration related protein 2 like
  charged multivesicular body protein 4B
  checkpoint with forkhead and ring finger domains
  chondroitin sulfate N-acetylgalactosaminyltransferase 2
  chromobox 4
  chromosome 18 open reading frame 25
  claudin 2
  coactivator associated arginine methyltransferase 1
  coiled-coil domain containing 6
  component of oligomeric golgi complex 1
  coronin 2A
  cystathionine beta-synthase like
  cytochrome P450 family 4 subfamily F member 2
  DAZ interacting zinc finger protein 3
  DEAD-box helicase 24
  deltex E3 ubiquitin ligase 3L
  denticleless E3 ubiquitin protein ligase homolog
  developmental pluripotency associated 2
  DExD-box helicase 21
  DExD-box helicase 39A
  DExD-box helicase 39B
  DNA meiotic recombinase 1
  EDAR associated death domain
  endothelial differentiation related factor 1
  exonuclease 1
  exportin 1
  exportin 7
  FA complementation group M
  family with sequence similarity 118 member A
  Fas associated factor 1
  Fas associated via death domain
  fetal and adult testis expressed 1
  germ cell-less 1, spermatogenesis associated
  germ cell-less 2, spermatogenesis associated
  GIPC PDZ domain containing family member 2
  glial cells missing transcription factor 1
  glucocorticoid modulatory element binding protein 1
  glucocorticoid modulatory element binding protein 2
  glutamate receptor interacting protein 1
  H4 clustered histone 1
  H4 clustered histone 14
  heat shock transcription factor 2 binding protein
  hepatocyte growth factor-regulated tyrosine kinase substrate
  heterogeneous nuclear ribonucleoprotein C like 1
  heterogeneous nuclear ribonucleoprotein L like
  histone deacetylase 4
  histone deacetylase 5
  histone deacetylase 7
  HMG-box containing 4
  homeobox containing 1
  homeodomain interacting protein kinase 1
  homeodomain interacting protein kinase 2
  homeodomain interacting protein kinase 2
  homeodomain interacting protein kinase 3
  hyaluronan binding protein 4
  IKAROS family zinc finger 1
  IKAROS family zinc finger 3
  IKAROS family zinc finger 5
  importin 13
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  IQ motif containing GTPase activating protein 1
  ISY1 splicing factor homolog
  jumonji domain containing 6, arginine demethylase and lysine hydroxylase
  kelch like family member 12
  kelch like family member 2
  keratin associated protein 5-2
  keratin associated protein 5-4
  KH-type splicing regulatory protein
  kinesin family member 1B
  Kruppel like factor 3
  large tumor suppressor kinase 1
  late cornified envelope 1D
  late cornified envelope 1F
  late cornified envelope 2C
  late cornified envelope 3B
  late cornified envelope 5A
  leucine rich repeat and sterile alpha motif containing 1
  ligand of numb-protein X 2
  LON peptidase N-terminal domain and ring finger 1
  lysine acetyltransferase 5
  lysine acetyltransferase 6B
  lysine demethylase 1A
  lysine methyltransferase 5A
  mahogunin ring finger 1
  makorin ring finger protein 3
  mal, T cell differentiation protein like
  matrin 3
  mediator complex subunit 7
  membrane associated ring-CH-type finger 5
  metastasis associated 1
  mirror-image polydactyly 1
  mitochondrial E3 ubiquitin protein ligase 1
  mitochondrial ribosomal protein L53
  mitogen-activated protein kinase 1 interacting protein 1 like
  MYB binding protein 1a
  myocardin related transcription factor A
  N-acetyltransferase 10
  NADPH oxidase 5
  NDC1 transmembrane nucleoporin
  ninein
  N-myc and STAT interactor
  NOP56 ribonucleoprotein
  NOP58 ribonucleoprotein
  nuclear assembly factor 1 ribonucleoprotein
  nuclear envelope integral membrane protein 1
  nuclear receptor binding SET domain protein 3
  nuclear receptor corepressor 1
  nuclear receptor corepressor 2
  nuclear receptor subfamily 1 group D member 2
  nuclear receptor subfamily 1 group H member 2
  nuclear receptor subfamily 1 group H member 3
  nuclear receptor subfamily 1 group I member 2
  nuclear RNA export factor 1
  nucleolar protein 6
  nucleoporin 107
  nucleoporin 107
  nucleoporin 153
  nucleoporin 155
  nucleoporin 205
  nucleoporin 210
  nucleoporin 214
  nucleoporin 35
  nucleoporin 85
  nucleoporin 93
  nucleoporin 98
  nucleus accumbens associated 1
  NudC domain containing 3
  Parkinsonism associated deglycase
  PDZ and LIM domain 7
  pellino E3 ubiquitin protein ligase 1
  phosphatase and actin regulator 4
  phosphopantothenoylcysteine decarboxylase
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  pleckstrin homology domain containing A4
  poly(U) binding splicing factor 60
  polycomb group ring finger 2
  potassium channel tetramerization domain containing 1
  potassium voltage-gated channel interacting protein 3
  PPARG coactivator 1 alpha
  pre-mRNA processing factor 40 homolog A
  pre-mRNA processing factor 8
  proteasome activator subunit 3
  protein activator of interferon induced protein kinase EIF2AK2
  protein inhibitor of activated STAT 1
  protein inhibitor of activated STAT 2
  protein inhibitor of activated STAT 3
  protein inhibitor of activated STAT 4
  protein phosphatase, Mg2+/Mn2+ dependent 1J
  Rab acceptor 1
  RAD18 E3 ubiquitin protein ligase
  RAD54 homolog B
  RAD54 like 2
  RAN binding protein 2
  RAN binding protein 9
  RAN GTPase activating protein 1
  receptor interacting serine/threonine kinase 2
  regulation of nuclear pre-mRNA domain containing 1B
  regulator of chromosome condensation 1
  ret finger protein like 3
  Rhox homeobox family member 2
  ribosomal protein S6 kinase A6
  ring finger and CCCH-type domains 2
  ring finger protein 10
  ring finger protein 111
  ring finger protein 115
  ring finger protein 128
  ring finger protein 133
  ring finger protein 144B
  ring finger protein 151
  ring finger protein 185
  ring finger protein 40
  RNA binding motif protein 14
  RNA binding motif protein 25
  RNA polymerase I subunit H
  RUS family member 1
  RuvB like AAA ATPase 1
  RWD domain containing 3
  SAP domain containing ribonucleoprotein
  SEH1 like nucleoporin
  SEM1 26S proteasome complex subunit
  semaphorin 6A
  senataxin
  SET binding protein 1
  SET domain bifurcated histone lysine methyltransferase 1
  SH3 domain containing GRB2 like, endophilin B1
  SH3 domain containing kinase binding protein 1
  sirtuin 1
  SLX4 structure-specific endonuclease subunit
  Smad nuclear interacting protein 1
  SMAD specific E3 ubiquitin protein ligase 2
  small nuclear ribonucleoprotein U5 subunit 200
  small ubiquitin like modifier 1
  solute carrier family 1 (glial high affinity glutamate transporter), member 2
  speckle type BTB/POZ protein
  sperm antigen with calponin homology and coiled-coil domains 1 like
  spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  splicing factor 3b subunit 4
  SPT7 like, STAGA complex subunit gamma
  SRY-box transcription factor 6
  staphylococcal nuclease and tudor domain containing 1
  stathmin 2
  SUMO1 activating enzyme subunit 1
  suppressor of cytokine signaling 6
  SURP and G-patch domain containing 1
  SUZ12 polycomb repressive complex 2 subunit
  symplekin
  syntaxin 1B
  TatD DNase domain containing 1
  taxilin beta
  TBL1X receptor 1
  teashirt zinc finger homeobox 2
  TGF-beta activated kinase 1 (MAP3K7) binding protein 2
  THAP domain containing 1
  thyroid hormone receptor interactor 13
  tigger transposable element derived 3
  TNF receptor associated factor 4
  TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
  tousled like kinase 2
  trafficking from ER to golgi regulator
  transcription elongation regulator 1
  transmembrane protein 209
  tripartite motif containing 24
  tripartite motif containing 28
  tripartite motif containing 29
  tripartite motif containing 3
  tripartite motif containing 33
  tripartite motif containing 38
  tripartite motif containing 41
  tripartite motif containing 54
  tripartite motif containing 55
  tripartite motif containing 63
  tripartite motif containing 72
  tripartite motif-containing 32
  tumor protein p63
  tyrosyl-DNA phosphodiesterase 2
  ubiquilin 1
  ubiquilin 2
  ubiquitin conjugating enzyme E2 I
  ubiquitin C-terminal hydrolase L1
  ubiquitin like modifier activating enzyme 2
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin specific peptidase 25
  ubiquitin specific peptidase 8
  UBX domain protein 1
  unc-119 lipid binding chaperone
  vascular endothelial zinc finger 1
  VENT homeobox
  v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)
  von Hippel-Lindau tumor suppressor
  WASP actin nucleation promoting factor
  WNK lysine deficient protein kinase 1
  WT1 transcription factor
  WW domain containing E3 ubiquitin protein ligase 2
  X-box binding protein 1
  X-ray repair cross complementing 1
  X-ray repair cross complementing 5
  Zic family member 1
  zinc finger and BTB domain containing 1
  zinc finger and BTB domain containing 16
  zinc finger and BTB domain containing 2
  zinc finger and BTB domain containing 26
  zinc finger and BTB domain containing 7A
  zinc finger and BTB domain containing 8A
  zinc finger and BTB domain containing 9
  zinc finger BED-type containing 1
  zinc finger CCCH-type containing 10
  zinc finger CCHC-type containing 12
  zinc finger CCHC-type containing 7
  zinc finger E-box binding homeobox 2
  zinc finger MYM-type containing 2
  zinc finger MYND-type containing 11
  zinc finger protein 106
  zinc finger protein 24
  zinc finger protein 408
  zinc finger protein 420
  zinc finger protein 446
  zinc finger protein 451
  zinc finger protein 618
  zinc finger protein 646
  zinc finger protein 837
  zinc fingers and homeoboxes 1
  zinc ribbon domain containing 2
  zymogen granule protein 16

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.