HSD17B10, hydroxysteroid 17-beta dehydrogenase 10

HSD17B10, hydroxysteroid 17-beta dehydrogenase 10

• This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Aug 2014]

• Gene Synonyms (3-hydroxyacyl-CoA dehydrogenase type-2, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, AB-binding alcohol dehydrogenase, amyloid-beta peptide binding alcohol dehydrogenase, endoplasmic reticulum-associated amyloid beta-peptide-binding protein, mitochondrial RNase P subunit 2, mitochondrial ribonuclease P protein 2, short chain L-3-hydroxyacyl-CoA dehydrogenase type 2, short chain type dehydrogenase/reductase XH98G2, 17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, HSD10MD, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1,)
• NCBI Gene ID: 3028
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0S2Z410
  UNIPROT ID#>>Q99714
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

hydroxysteroid 17-beta dehydrogenase 10 interacts with:

• 3-hydroxy-3-methylglutaryl-CoA lyase
  3-hydroxy-3-methylglutaryl-CoA synthase 2
  3-hydroxy-3-methylglutaryl-Coenzyme A lyase
  3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
  3-hydroxyisobutyrate dehydrogenase
  AAR2 splicing factor
  acetyl-CoA acyltransferase 2
  acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
  actin related protein 2
  actin related protein 2/3 complex subunit 3
  actin related protein 3
  acyl-CoA synthetase medium-chain family member 2
  acyl-CoA synthetase short-chain family member 1
  acyl-CoA thioesterase 7
  acyl-coenzyme A amino acid N-acyltransferase 1
  acyl-Coenzyme A dehydrogenase family, member 10
  acyl-Coenzyme A dehydrogenase, long-chain
  acyl-Coenzyme A dehydrogenase, medium chain
  acyl-Coenzyme A dehydrogenase, short chain
  acyl-Coenzyme A dehydrogenase, very long chain
  acyl-Coenzyme A oxidase 1, palmitoyl
  ADP ribosylation factor GTPase activating protein 2
  ADP ribosylation factor GTPase activating protein 3
  alcohol dehydrogenase 4 (class II), pi polypeptide
  aldehyde dehydrogenase family 3, subfamily A1
  aldo-keto reductase family 1 member B15
  aldolase C, fructose-bisphosphate
  alpha-2-macroglobulin
  Aly/REF export factor
  amino carboxymuconate semialdehyde decarboxylase
  aminoacylase 1
  aminolevulinate, delta-, dehydratase
  ankyrin repeat and SOCS box containing 1
  anoctamin 7
  anterior gradient 2, protein disulphide isomerase family member
  apoptosis inducing factor mitochondria associated 1
  arginase type II
  argininosuccinate lyase
  argininosuccinate synthetase 1
  asparaginase
  ATPase H+ transporting V1 subunit H
  ATPase, H+ transporting, lysosomal V0 subunit C
  ATPase, H+ transporting, lysosomal V0 subunit D1
  ATPase, H+ transporting, lysosomal V0 subunit E
  ATPase, H+ transporting, lysosomal V1 subunit F
  aurora kinase A interacting protein 1
  autophagy related 16 like 1
  basic leucine zipper and W2 domains 1
  basic leucine zipper and W2 domains 2
  BCL2 like 14
  brain glycogen phosphorylase
  BUB3 mitotic checkpoint protein
  calcyclin binding protein
  carbamoyl-phosphate synthetase 1
  carbonic anhydrase 3
  carboxylesterase 3A
  carboxypeptidase vitellogenic like
  carnitine palmitoyltransferase 2
  catalase
  CD2 cytoplasmic tail binding protein 2
  cell cycle and apoptosis regulator 2
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  chromatin target of PRMT1
  citrate synthase
  cleavage and polyadenylation specific factor 6
  COP9 signalosome subunit 5
  COP9 signalosome subunit 8
  COPI coat complex subunit epsilon
  creatine kinase, brain
  creatine kinase, muscle
  cubilin (intrinsic factor-cobalamin receptor)
  cullin 1
  cullin 3
  cullin 4A
  cullin 4B
  cullin 5
  cullin 7
  cullin associated and neddylation dissociated 1
  cystatin C
  cytochrome c oxidase subunit 5A
  DEAD-box helicase 19A
  dehydrogenase E1 and transketolase domain containing 1
  dihydrolipoamide branched chain transacylase E2
  dihydrolipoamide dehydrogenase
  dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
  dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
  dihydropyrimidinase-like 2
  dual specificity phosphatase 26
  dynamin 1 like
  egl-9 family hypoxia inducible factor 3
  elaC ribonuclease Z 2
  electron transferring flavoprotein, alpha polypeptide
  electron transferring flavoprotein, beta polypeptide
  elongation factor Tu GTP binding domain containing 2
  enolase 1, alpha non-neuron
  enolase 2, gamma neuronal
  enolase 3, beta muscle
  enoyl coenzyme A hydratase 1, peroxisomal
  eukaryotic translation elongation factor 1 epsilon 1
  eukaryotic translation initiation factor 3 subunit D
  eukaryotic translation initiation factor 3 subunit I
  eukaryotic translation initiation factor 3, subunit A
  eukaryotic translation initiation factor 4A3
  ezrin
  Fas associated factor 1
  fatty acid binding protein 1, liver
  fumarate hydratase 1
  fumarylacetoacetate hydrolase
  glucose-6-phosphate isomerase 1
  glutamate-ammonia ligase (glutamine synthetase)
  glutathione peroxidase 1
  glutathione S-transferase omega 1
  glutathione S-transferase, alpha 1 (Ya)
  glutathione S-transferase, alpha 4
  glutathione S-transferase, mu 1
  glutathione S-transferase, mu 2
  glutathione S-transferase, mu 5
  glutathione S-transferase, pi 1
  glutathione S-transferase, theta 1
  glyceraldehyde-3-phosphate dehydrogenase
  glycine amidinotransferase (L-arginine:glycine amidinotransferase)
  glycogen phosphorylase L
  H2A clustered histone 4
  heat shock protein 1 (chaperonin)
  heat shock protein 2
  heat shock protein 90 beta family member 1
  heat shock protein family A (Hsp70) member 9
  heat shock protein family D (Hsp60) member 1
  heat shock protein family E (Hsp10) member 1
  heat shock protein, alpha-crystallin-related, B6
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  hemoglobin subunit alpha 1
  hemoglobin subunit alpha 2
  hemoglobin subunit beta
  heparin binding growth factor
  heterogeneous nuclear ribonucleoprotein A/B
  heterogeneous nuclear ribonucleoprotein A1 like 2
  heterogeneous nuclear ribonucleoprotein A2/B1
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein D like
  heterogeneous nuclear ribonucleoprotein H3
  heterogeneous nuclear ribonucleoprotein U like 2
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 1
  histone deacetylase 5
  homogentisate 1, 2-dioxygenase
  HtrA serine peptidase 2
  huntingtin
  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
  hydroxyacyl-Coenzyme A dehydrogenase
  hypoxanthine phosphoribosyltransferase 1
  inositol-3-phosphate synthase 1
  integrin subunit alpha 4
  interleukin enhancer binding factor 2
  isocitrate dehydrogenase 1 (NADP+), soluble
  isocitrate dehydrogenase 3 (NAD+) alpha
  isovaleryl coenzyme A dehydrogenase
  junction plakoglobin
  karyopherin subunit beta 1
  La ribonucleoprotein 7, transcriptional regulator
  lactate dehydrogenase A
  lactate dehydrogenase B
  lactate dehydrogenase C
  leucine rich repeat kinase 2
  low density lipoprotein receptor-related protein 2
  lysosomal associated membrane protein 1
  lysyl-tRNA synthetase 1
  malate dehydrogenase 1
  malate dehydrogenase 1, NAD (soluble)
  malate dehydrogenase 2
  methionine adenosyltransferase 2A
  methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
  methylcrotonoyl-Coenzyme A carboxylase 2 (beta)
  methylphosphate capping enzyme
  minichromosome maintenance complex component 2
  minichromosome maintenance complex component 3
  minichromosome maintenance complex component 4
  minichromosome maintenance complex component 5
  mitochondrial ribosomal protein L58
  mitochondrial rRNA methyltransferase 1
  mitogen-activated protein kinase kinase kinase kinase 1
  MOB kinase activator 1B
  moesin
  myosin light chain 1
  myosin light chain 12A
  myosin light chain 6
  myosin VI
  myosin, heavy polypeptide 4, skeletal muscle
  N(alpha)-acetyltransferase 11, NatA catalytic subunit
  NADH:ubiquinone oxidoreductase core subunit S2
  NADH:ubiquinone oxidoreductase core subunit V1
  NADH:ubiquinone oxidoreductase core subunit V2
  NADH:ubiquinone oxidoreductase subunit A7
  N-alpha-acetyltransferase 50, NatE catalytic subunit
  nascent polypeptide associated complex subunit alpha
  neurotrophic receptor tyrosine kinase 1
  neutrophil cytosolic factor 1
  nicotinamide phosphoribosyltransferase
  NOP10 ribonucleoprotein
  NOP56 ribonucleoprotein
  NOP58 ribonucleoprotein
  nuclear cap binding protein subunit 1
  nuclear receptor subfamily 2 group C member 2
  nucleosome assembly protein 1 like 1
  nucleosome assembly protein 1 like 4
  obscurin like cytoskeletal adaptor 1
  ornithine aminotransferase
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
  oxoglutarate dehydrogenase
  parkin RBR E3 ubiquitin protein ligase
  Parkinsonism associated deglycase
  PEDS1-UBE2V1 readthrough
  peptidase, mitochondrial processing subunit beta
  peptidylprolyl isomerase A
  peptidylprolyl isomerase B
  peripherin
  peroxiredoxin 1
  peroxiredoxin 2
  peroxiredoxin 2
  peroxiredoxin 3
  peroxiredoxin 5
  peroxiredoxin 6
  peroxiredoxin 6
  phosphatidylinositol transfer protein beta
  phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
  phosphoglycerate kinase 1
  phosphoglycerate mutase 1
  phosphoglycerate mutase 2
  phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 1
  polypyrimidine tract binding protein 1
  pre-mRNA processing factor 19
  pre-mRNA processing factor 8
  progesterone receptor membrane component 1
  programmed cell death 6 interacting protein
  prohibitin
  prolyl 4-hydroxylase subunit beta
  propionyl-Coenzyme A carboxylase, alpha polypeptide
  proteasome (prosome, macropain) subunit, beta type 5
  proteasome 20S subunit beta 1
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 4
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 6
  proteasome 26S subunit, non-ATPase 7
  proteasome activator subunit 2
  proteasome activator subunit 3
  protein disulfide isomerase family A member 6
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 2 scaffold subunit Aalpha
  protein-L-isoaspartate (D-aspartate) O-methyltransferase
  proteolipid protein 2
  PTEN induced kinase 1
  pyrophosphatase (inorganic) 2
  pyruvate dehydrogenase (lipoamide) beta
  pyruvate dehydrogenase complex component X
  pyruvate dehydrogenase complex, component X
  pyruvate dehydrogenase E1 alpha 1
  pyruvate dehydrogenase E1 alpha 2
  pyruvate dehydrogenase E1 subunit alpha 1
  pyruvate dehydrogenase E1 subunit beta
  pyruvate dehydrogenase kinase 1
  pyruvate kinase, muscle
  quinoid dihydropteridine reductase
  RAB11A, member RAS oncogene family
  RAB8A, member RAS oncogene family
  RAB8B, member RAS oncogene family
  Rac family small GTPase 1
  radixin
  RALY heterogeneous nuclear ribonucleoprotein
  RB binding protein 7, chromatin remodeling factor
  RBMX like 2
  RecQ like helicase 4
  reticulocalbin 1
  reticulon 4
  ribosomal protein L10a
  ribosomal protein L30
  ribosomal protein L35
  ring finger and CCCH-type domains 1
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA binding protein with serine rich domain 1
  RNA polymerase II, I and III subunit E
  RNA polymerase II, I and III subunit H
  RuvB like AAA ATPase 1
  RuvB like AAA ATPase 2
  SEC31 homolog A, COPII coat complex component
  SERPINE1 mRNA binding protein 1
  sideroflexin 1
  signal recognition particle 72
  sirtuin 3
  small nuclear ribonucleoprotein 13
  small ubiquitin like modifier 2
  snail family transcriptional repressor 1
  solute carrier family 12 member 4
  spindlin 1
  splicing factor 3b subunit 6
  SRY-box transcription factor 2
  stress induced phosphoprotein 1
  succinate dehydrogenase complex flavoprotein subunit A
  succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
  succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
  succinate-CoA ligase, GDP-forming, alpha subunit
  succinate-Coenzyme A ligase, GDP-forming, beta subunit
  succinyl-CoA glutarate-CoA transferase
  sulfite oxidase
  suppressor of cytokine signaling 1
  TAR DNA binding protein
  TDP-glucose 4,6-dehydratase
  thyroid hormone receptor interactor 6
  TNF receptor associated factor 5
  TNF receptor associated factor 6
  TNF receptor associated protein 1
  TPD52 like 2
  TRAF3 interacting protein 2
  transcription factor 7 like 2
  transgelin
  transgelin 2
  transgelin 3
  transketolase
  translocase of outer mitochondrial membrane 20
  translocase of outer mitochondrial membrane 22
  translocase of outer mitochondrial membrane 40
  transmembrane p24 trafficking protein 10
  triosephosphate isomerase 1
  triosephosphate isomerase 1
  tripartite motif containing 14
  tripartite motif containing 28
  tRNA methyltransferase 10C, mitochondrial RNase P subunit
  tRNA methyltransferase 61B
  ubiquitin conjugating enzyme E2 D1
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 V1
  ubiquitin C-terminal hydrolase L3
  ubiquitin like modifier activating enzyme 1
  ubiquitin like modifier activating enzyme 2
  VAMP associated protein A
  vinculin
  WT1 associated protein
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  X-ray repair cross complementing 5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.