UBE2D3, ubiquitin conjugating enzyme E2 D3

UBE2D3, ubiquitin conjugating enzyme E2 D3

• The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. [provided by RefSeq, Jan 2017]

• Gene Synonyms (ubiquitin-conjugating enzyme E2 D3, (E3-independent) E2 ubiquitin-conjugating enzyme D3, E2 ubiquitin-conjugating enzyme D3, ubiquitin carrier protein D3, ubiquitin conjugating enzyme E2D 3, ubiquitin-conjugating enzyme E2(17)KB 3, ubiquitin-conjugating enzyme E2-17 kDa 3, ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5), ubiquitin-protein ligase D3, E2(17)KB3, UBC4/5, UBCH5C,)
• NCBI Gene ID: 7323
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024RDH2
  UNIPROT ID#>>D6RAH7
  UNIPROT ID#>>P61077
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin conjugating enzyme E2 D3 interacts with:

• anaphase promoting complex subunit 11
  apoptosis resistant E3 ubiquitin protein ligase 1
  ariadne RBR E3 ubiquitin protein ligase 1
  ariadne RBR E3 ubiquitin protein ligase 2
  aurora kinase B
  autophagy and beclin 1 regulator 1
  baculoviral IAP repeat containing 7
  beta-transducin repeat containing E3 ubiquitin protein ligase
  bifunctional apoptosis regulator
  breast cancer 1, early onset
  BTB domain containing 8
  calcium dependent secretion activator 2
  Cbl proto-oncogene C
  checkpoint with forkhead and ring finger domains
  cullin 4B
  DAZ interacting zinc finger protein 3
  defective in cullin neddylation 1 domain containing 1
  deltex E3 ubiquitin ligase 2
  deltex E3 ubiquitin ligase 3
  deltex E3 ubiquitin ligase 3L
  DExD/H-box helicase 58
  DNA polymerase lambda
  DNA polymerase mu
  ERGIC and golgi 3
  ETAA1 activator of ATR kinase
  F-box and leucine rich repeat protein 12
  F-box and leucine rich repeat protein 2
  F-box and WD repeat domain containing 11
  F-box and WD repeat domain containing 8
  F-box protein 2
  F-box protein 25
  F-box protein 7
  fizzy and cell division cycle 20 related 1
  focadhesin
  H2A clustered histone 4
  H3 clustered histone 1
  H4 clustered histone 1
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
  HECT domain E3 ubiquitin protein ligase 1
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  histone deacetylase 6
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  ISG15 ubiquitin like modifier
  itchy E3 ubiquitin protein ligase
  leucine rich repeat and sterile alpha motif containing 1
  lysine acetyltransferase 2B
  lysine demethylase 1B
  macrophage erythroblast attacher, E3 ubiquitin ligase
  mahogunin ring finger 1
  makorin ring finger protein 1
  makorin ring finger protein 3
  membrane associated ring-CH-type finger 3
  membrane associated ring-CH-type finger 5
  membrane associated ring-CH-type finger 7
  membrane associated ring-CH-type finger 8
  mex-3 RNA binding family member B
  mex-3 RNA binding family member C
  midline 2
  mindbomb E3 ubiquitin protein ligase 1
  mitochondrial E3 ubiquitin protein ligase 1
  MSL complex subunit 1
  MSL complex subunit 2
  MYC binding protein 2
  myosin regulatory light chain interacting protein
  NEDD4 like E3 ubiquitin protein ligase
  neural precursor cell expressed, developmentally down-regulated 4
  NHL repeat containing E3 ubiquitin protein ligase 1
  nitric oxide synthase interacting protein
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  pellino E3 ubiquitin protein ligase 1
  period circadian regulator 2
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  polycomb group ring finger 1
  polycomb group ring finger 2
  polycomb group ring finger 3
  polycomb group ring finger 5
  polycomb group ring finger 6
  praja ring finger ubiquitin ligase 1
  praja ring finger ubiquitin ligase 2
  pre-mRNA processing factor 19
  programmed cell death 5
  protein prenyltransferase alpha subunit repeat containing 1
  RAB guanine nucleotide exchange factor 1
  RANBP2-type and C3HC4-type zinc finger containing 1
  required for meiotic nuclear division 5 homolog B
  ring finger and CHY zinc finger domain containing 1
  ring finger and FYVE like domain containing E3 ubiquitin protein ligase
  ring finger and SPRY domain containing 1
  ring finger and WD repeat domain 3
  ring finger protein 10
  ring finger protein 103
  ring finger protein 11
  ring finger protein 111
  ring finger protein 112
  ring finger protein 114
  ring finger protein 115
  ring finger protein 115
  ring finger protein 122
  ring finger protein 125
  ring finger protein 126
  ring finger protein 13
  ring finger protein 130
  ring finger protein 14
  ring finger protein 146
  ring finger protein 150
  ring finger protein 165
  ring finger protein 166
  ring finger protein 167
  ring finger protein 168
  ring finger protein 181
  ring finger protein 185
  ring finger protein 19B
  ring finger protein 216
  ring finger protein 220
  ring finger protein 25
  ring finger protein 26
  ring finger protein 31
  ring finger protein 38
  ring finger protein 41
  ring finger protein 43
  ring finger protein 7
  ring finger protein 8
  ring finger protein, LIM domain interacting
  ring finger protein, transmembrane 1
  ring-box 1
  ring-box 1
  sequestosome 1
  serine/threonine kinase 25
  SH3 domain containing ring finger 1
  SHOC2 leucine rich repeat scaffold protein
  signal transducing adaptor molecule 2
  SMAD specific E3 ubiquitin protein ligase 1
  SMAD specific E3 ubiquitin protein ligase 1
  SMAD specific E3 ubiquitin protein ligase 2
  STIP1 homology and U-box containing protein 1
  STIP1 homology and U-Box containing protein 1
  suppression of tumorigenicity 7
  synoviolin 1
  TNF receptor-associated factor 6
  TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
  TRAF interacting protein
  transformed mouse 3T3 cell double minute 4
  transmembrane protein 129, E3 ubiquitin ligase
  tripartite motif containing 10
  tripartite motif containing 11
  tripartite motif containing 17
  tripartite motif containing 2
  tripartite motif containing 25
  tripartite motif containing 26
  tripartite motif containing 28
  tripartite motif containing 31
  tripartite motif containing 32
  tripartite motif containing 33
  tripartite motif containing 35
  tripartite motif containing 38
  tripartite motif containing 39
  tripartite motif containing 43
  tripartite motif containing 45
  tripartite motif containing 5
  tripartite motif containing 50
  tripartite motif containing 54
  tripartite motif containing 55
  tripartite motif containing 58
  tripartite motif containing 62
  tripartite motif containing 63
  tripartite motif containing 68
  tripartite motif containing 69
  tripartite motif containing 7
  tripartite motif containing 8
  tripartite motif-containing 56
  tubulin alpha 1a
  tumor protein p63
  ubiquitin associated and SH3 domain containing B
  ubiquitin conjugating enzyme E2 C
  ubiquitin conjugating enzyme E2 D3
  ubiquitin conjugating enzyme E2 O
  ubiquitin conjugating enzyme E2 S
  ubiquitin domain containing 1
  ubiquitin fold modifier 1
  ubiquitin like modifier activating enzyme 6
  ubiquitin like with PHD and ring finger domains 1
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin protein ligase E3A
  ubiquitin protein ligase E3C
  ubiquitin specific peptidase 7
  ubiquitination factor E4A
  ubiquitination factor E4A
  ubiquitination factor E4B
  ubiquitination factor E4B
  U-box domain containing 5
  UV stimulated scaffold protein A
  WD repeat and SOCS box containing 1
  WW domain containing E3 ubiquitin protein ligase 1
  WW domain containing E3 ubiquitin protein ligase 2
  X-prolyl aminopeptidase 1
  zinc and ring finger 1
  zinc and ring finger 2
  zinc and ring finger 4
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.