TRIM28, tripartite motif containing 28

TRIM28, tripartite motif containing 28

• The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]

• Gene Synonyms (transcription intermediary factor 1-beta, E3 SUMO-protein ligase TRIM28, KAP-1, KRAB [Kruppel-associated box domain]-associated protein 1, KRAB-interacting protein 1, KRIP-1, RING finger protein 96, RING-type E3 ubiquitin transferase TIF1-beta, TIF1-beta, nuclear corepressor KAP-1, protein phosphatase 1, regulatory subunit 157, transcriptional intermediary factor 1-beta, KAP1, PPP1R157, RNF96, TF1B, TIF1B,)
• NCBI Gene ID: 10155
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13263
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tripartite motif containing 28 interacts with:

• 1-acylglycerol-3-phosphate O-acyltransferase 5
  5'-3' exoribonuclease 2
  6-phosphogluconolactonase
  AAR2 splicing factor
  acetyl-CoA acyltransferase 2
  acidic nuclear phosphoprotein 32 family member E
  activating signal cointegrator 1 complex subunit 3
  activator of HSP90 ATPase activity 1
  acyl-CoA thioesterase 7
  A-kinase anchoring protein 8
  alanyl-tRNA synthetase 2, mitochondrial
  aldehyde dehydrogenase 16 family member A1
  ALG5 dolichyl-phosphate beta-glucosyltransferase
  anillin actin binding protein
  ankyrin repeat and KH domain containing 1
  ankyrin repeat domain 17
  ankyrin repeat family A member 2
  anterior gradient 2, protein disulphide isomerase family member
  ariadne RBR E3 ubiquitin protein ligase 1
  ariadne RBR E3 ubiquitin protein ligase 2
  asparaginyl-tRNA synthetase 2, mitochondrial
  aspartyl-tRNA synthetase 2, mitochondrial
  autophagy related 16 like 1
  baculoviral IAP repeat containing 6
  BCAS2 pre-mRNA processing factor
  BCL2-associated athanogene 2
  BRCA1/BRCA2-containing complex subunit 3
  bromo adjacent homology domain containing 1
  bromodomain containing 7
  BUD23 rRNA methyltransferase and ribosome maturation factor
  caseinolytic mitochondrial matrix peptidase chaperone subunit X
  catenin beta like 1
  CCR4-NOT transcription complex subunit 1
  CDK5 regulatory subunit associated protein 3
  cell division cycle 37, HSP90 cochaperone
  cell division cycle 73
  cell division cycle and apoptosis regulator 1
  cell division cycle associated 4
  centrosomal protein 250
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  checkpoint kinase 2
  chromobox 1
  chromobox 1
  chromobox 3
  chromobox 3
  chromobox 5
  chromosome 9 open reading frame 64
  chromosome alignment maintaining phosphoprotein 1
  coactivator associated arginine methyltransferase 1
  coiled-coil domain containing 47
  coiled-coil domain containing 8
  coiled-coil-helix-coiled-coil-helix domain containing 3
  COP9 signalosome subunit 5
  COPI coat complex subunit gamma 1
  COPI coat complex subunit gamma 2
  COPI coat complex subunit zeta 1
  coronin 1B
  coronin 1C
  CTP synthase 2
  cullin associated and neddylation dissociated 1
  cullin associated and neddylation dissociated 2 (putative)
  cyclin dependent kinase 12
  cytidine monophosphate N-acetylneuraminic acid synthetase
  cytochrome c, somatic
  cytoplasmic FMR1 interacting protein 1
  DAZ associated protein 1
  DDB1 and CUL4 associated factor 13
  DEAD-box helicase 17
  DEAD-box helicase 19A
  DEAD-box helicase 19B
  DEAD-box helicase 24
  DEAH-box helicase 33
  DEAH-box helicase 37
  DExD-box helicase 39A
  DExD-box helicase 52
  DExH-box helicase 29
  DExH-box helicase 30
  DIMT1 rRNA methyltransferase and ribosome maturation factor
  diphthamine biosynthesis 6
  distal membrane arm assembly complex 2
  DnaJ heat shock protein family (Hsp40) member A2
  DnaJ heat shock protein family (Hsp40) member C9
  dual specificity phosphatase 23
  dynactin subunit 4
  dynactin subunit 5
  eEF1A lysine and N-terminal methyltransferase
  EH domain containing 4
  elongation factor like GTPase 1
  elongator acetyltransferase complex subunit 2
  ENAH actin regulator
  endoplasmic reticulum-golgi intermediate compartment 1
  epiplakin 1
  ER lipid raft associated 2
  ER membrane protein complex subunit 1
  ethylmalonyl-CoA decarboxylase 1
  euchromatic histone lysine methyltransferase 1
  euchromatic histone lysine methyltransferase 2
  eukaryotic translation initiation factor 2A
  eukaryotic translation initiation factor 3 subunit L
  exocyst complex component 4
  exosome component 1
  exosome component 3
  exosome component 8
  Fas associated factor 1
  Fas associated factor family member 2
  F-box protein 6
  fibronectin type III domain containing 3A
  GCN1 activator of EIF2AK4
  GDP-mannose pyrophosphorylase A
  GDP-mannose pyrophosphorylase B
  gem nuclear organelle associated protein 7
  glutamate rich WD repeat containing 1
  guanosine monophosphate reductase 2
  haloacid dehalogenase like hydrolase domain containing 5
  HAUS augmin like complex subunit 2
  HAUS augmin-like complex, subunit 4
  HCLS1 associated protein X-1
  HEAT repeat containing 1
  heat shock protein family A (Hsp70) member 14
  heterogeneous nuclear ribonucleoprotein L like
  heterogeneous nuclear ribonucleoprotein R
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 10
  HIV-1 Tat specific factor 1
  HtrA serine peptidase 2
  huntingtin interacting protein K
  hydroxysteroid 17-beta dehydrogenase 7
  hydroxysteroid dehydrogenase like 1
  ILK associated serine/threonine phosphatase
  IMP U3 small nucleolar ribonucleoprotein 3
  importin 4
  importin 8
  insulin like growth factor 2 mRNA binding protein 1
  insulin like growth factor 2 mRNA binding protein 2
  insulin like growth factor 2 mRNA binding protein 3
  integrator complex subunit 11
  integrin alpha FG-GAP repeat containing 1
  IQ motif containing GTPase activating protein 2
  IQ motif containing GTPase activating protein 3
  isoleucyl-tRNA synthetase 2, mitochondrial
  Jupiter microtubule associated homolog 1
  karyopherin (importin) alpha 1
  karyopherin (importin) alpha 2
  karyopherin (importin) alpha 4
  karyopherin subunit alpha 6
  KDEL endoplasmic reticulum protein retention receptor 1
  KH RNA binding domain containing, signal transduction associated 1
  kinase suppressor of ras 1
  kinesin family binding protein
  kinesin family member 13B
  KRAB box domain containing 4
  L3MBTL histone methyl-lysine binding protein 1
  La ribonucleoprotein 7, transcriptional regulator
  leucine aminopeptidase 3
  leucine carboxyl methyltransferase 1
  leucine rich repeat containing 47
  leucine rich repeats and WD repeat domain containing 1
  leucyl-tRNA synthetase 1
  lin-28 homolog B
  LINE1 type transposase domain containing 1
  lipid droplet associated hydrolase
  listerin E3 ubiquitin protein ligase 1
  LSM12 homolog
  lysine demethylase 1A
  lysophospholipase 1
  lysophospholipase 2
  lysophospholipase like 1
  MAGE family member A2B
  MAGE family member C2
  MAGE family member E1
  matrix AAA peptidase interacting protein 1
  mediator of cell motility 1
  membrane bound O-acyltransferase domain containing 7
  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
  methylphosphate capping enzyme
  methylthioribose-1-phosphate isomerase 1
  methyltransferase like 14
  methyltransferase like 3
  mex-3 RNA binding family member C
  microtubule associated protein 1S
  microtubule associated serine/threonine kinase 3
  minichromosome maintenance complex component 3
  minichromosome maintenance complex component 6
  MIS12 kinetochore complex component
  misato mitochondrial distribution and morphology regulator 1
  mitochondrial poly(A) polymerase
  mitochondrial ribosomal protein L11
  mitochondrial ribosomal protein L22
  mitochondrial ribosomal protein L24
  mitochondrial ribosomal protein L37
  mitochondrial ribosomal protein L9
  mitochondrial ribosomal protein S10
  mitochondrial ribosomal protein S15
  mitochondrial ribosomal protein S18B
  mitochondrial ribosomal protein S22
  mitochondrial ribosomal protein S23
  mitochondrial ribosomal protein S24
  mitochondrial ribosomal protein S26
  mitochondrial ribosomal protein S27
  mitochondrial ribosomal protein S30
  mitochondrial ribosomal protein S31
  mitochondrial ribosomal protein S34
  mitochondrial ribosomal protein S35
  mitochondrial ribosomal protein S9
  MORC family CW-type zinc finger 2
  Mtr4 exosome RNA helicase
  musashi RNA binding protein 2
  MYB binding protein 1a
  myosin light chain 12A
  NAD(P) dependent steroid dehydrogenase-like
  NBAS subunit of NRZ tethering complex
  NCK associated protein 1
  negative elongation factor complex member B
  NIPBL cohesin loading factor
  nitric oxide synthase interacting protein
  non-SMC condensin I complex subunit G
  non-SMC condensin I complex subunit H
  non-SMC condensin II complex subunit D3
  non-SMC condensin II complex subunit G2
  NOP2/Sun RNA methyltransferase 5
  NOP56 ribonucleoprotein
  NOP58 ribonucleoprotein
  NOP9 nucleolar protein
  notchless homolog 1
  NSE3 homolog, SMC5-SMC6 complex component
  nuclear factor, erythroid derived 2, like 2
  nuclear RNA export factor 1
  nucleolar pre-rRNA processing protein NIP7
  nucleolar protein 11
  nucleolar protein 6
  nucleophosmin/nucleoplasmin 3
  nucleoporin 133
  nucleoporin 160
  nucleoporin 188
  nucleoporin 205
  nucleoporin 35
  nucleoporin 62
  nucleoside-triphosphatase, cancer-related
  obscurin like cytoskeletal adaptor 1
  O-sialoglycoprotein endopeptidase
  paired box 3
  PAK1 interacting protein 1
  Parkinsonism associated deglycase
  PDS5 cohesin associated factor A
  PDS5 cohesin associated factor B
  pescadillo ribosomal biogenesis factor 1
  phosphodiesterase 12
  PIH1 domain containing 1
  pleckstrin homology domain containing A2
  pleckstrin homology domain containing A4
  pogo transposable element derived with KRAB domain
  polycomb group ring finger 6
  pre-mRNA processing factor 31
  pre-mRNA processing factor 38A
  pre-mRNA processing factor 39
  pre-mRNA processing factor 6
  pre-mRNA processing factor 8
  programmed cell death 11
  prohibitin 2
  proliferating cell nuclear antigen
  proteasome 26S subunit, non-ATPase 14
  protein arginine methyltransferase 3
  protein kinase D2
  protein phosphatase 4 regulatory subunit 3B
  protein phosphatase methylesterase 1
  protein tyrosine phosphatase non-receptor type 23
  PTEN induced kinase 1
  pyridoxal phosphatase
  pyrroline-5-carboxylate reductase 2
  pyruvate dehydrogenase phosphatase regulatory subunit
  RAB1B, member RAS oncogene family
  RAB21, member RAS oncogene family
  RAB3 GTPase activating non-catalytic protein subunit 2
  RAB3 GTPase activating protein catalytic subunit 1
  RAD18 E3 ubiquitin protein ligase
  RALY heterogeneous nuclear ribonucleoprotein
  RANBP2 like and GRIP domain containing 3
  ras homolog family member T1
  ras homolog family member T2
  RAS related 2
  receptor for activated C kinase 1
  replication termination factor 2
  retinol dehydrogenase 11
  ribonuclease P/MRP subunit p30
  ribosomal L24 domain containing 1
  ribosomal protein S19 binding protein 1
  ribosomal RNA processing 1 homolog B (S. cerevisiae)
  ribosomal RNA processing 1B
  RIC8 guanine nucleotide exchange factor A
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 20
  ring finger protein 31
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA polymerase I subunit A
  RNA polymerase I subunit B
  RNA polymerase II associated protein 1
  RNA polymerase III subunit A
  RNA polymerase III subunit B
  RuvB like AAA ATPase 2
  SAC1 like phosphatidylinositide phosphatase
  salt inducible kinase 2
  SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
  scribble planar cell polarity protein
  sec1 family domain containing 1
  SEC11 homolog A, signal peptidase complex subunit
  SEC23 homolog B, COPII coat complex component
  SEC31 homolog A, COPII coat complex component
  SEC61 translocon subunit alpha 1
  septin 9
  serine palmitoyltransferase long chain base subunit 1
  serine/threonine kinase 26
  serrate, RNA effector molecule
  SERTA domain containing 1
  SET nuclear oncogene
  SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
  sideroflexin 1
  signal peptidase complex subunit 3
  SIN3 transcription regulator family member A
  single stranded DNA binding protein 3
  sirtuin 1
  sirtuin 6
  SMAD specific E3 ubiquitin protein ligase 1
  small nuclear ribonucleoprotein U5 subunit 200
  SMU1 DNA replication regulator and spliceosomal factor
  solute carrier family 25 member 13
  solute carrier family 25 member 22
  sorting nexin 27
  spermatid perinuclear RNA binding protein
  spindle apparatus coiled-coil protein 1
  SprT-like N-terminal domain
  SPT16 homolog, facilitates chromatin remodeling subunit
  SSU72 homolog, RNA polymerase II CTD phosphatase
  staphylococcal nuclease and tudor domain containing 1
  staufen double-stranded RNA binding protein 2
  stomatin like 2
  stromal antigen 1
  stromal cell derived factor 4
  structural maintenance of chromosomes 2
  SUMO specific peptidase 3
  SUMO specific peptidase 7
  suppressor of variegation 3-9 1
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  syntaxin 18
  TAR DNA binding protein
  target of EGR1, exonuclease
  TBC1 domain family member 23
  TBL1X receptor 1
  testin LIM domain protein
  thioredoxin interacting protein
  thioredoxin related transmembrane protein 1
  THO complex 6
  THUMP domain containing 1
  THUMP domain containing 3
  TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
  TP53 regulating kinase
  TRAF2 and NCK interacting kinase
  trafficking protein particle complex 11
  transformer 2 alpha homolog
  translational activator of cytochrome c oxidase I
  translocase of inner mitochondrial membrane 21
  translocase of inner mitochondrial membrane 44
  translocase of inner mitochondrial membrane 50
  translocase of outer mitochondrial membrane 22
  translocase of outer mitochondrial membrane 34
  transmembrane and coiled-coil domains 1
  tripartite motif containing 11
  tripartite motif containing 17
  tripartite motif containing 28
  tripartite motif containing 33
  tripartite motif containing 6
  tripartite motif-containing 24
  tripartite motif-containing 28
  tRNA methyltransferase 1
  tubulin alpha 1b
  tubulin beta 2B class IIb
  tubulin beta 3 class III
  tubulin beta 4A class IVa
  tubulin beta 4B class IVb
  tubulin beta 6 class V
  tubulin beta class I
  tubulin tyrosine ligase like 12
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 C
  ubiquitin conjugating enzyme E2 U
  ubiquitin like with PHD and ring finger domains 1
  ubiquitin protein ligase E3 component n-recognin 4
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitination factor E4B
  UPF2 regulator of nonsense mediated mRNA decay
  UTP15 small subunit processome component
  UTP20 small subunit processome component
  UTP4 small subunit processome component
  UTP6 small subunit processome component
  valosin containing protein interacting protein 1
  vesicle trafficking 1
  vir like m6A methyltransferase associated
  VPS16 core subunit of CORVET and HOPS complexes
  VPS26, retromer complex component B
  VPS33B late endosome and lysosome associated
  WASH complex subunit 4
  WD repeat and HMG-box DNA binding protein 1
  WD repeat domain 18
  WD repeat domain 33
  WD repeat domain 61
  WD repeat domain 82
  WRN helicase interacting protein 1
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  YME1 like 1 ATPase
  YTH domain containing 2
  YTH N6-methyladenosine RNA binding protein 2
  ZFP1 zinc finger protein
  ZFP57 zinc finger protein
  zinc finger and BTB domain containing 1
  zinc finger CCCH-type containing 7B
  zinc finger containing ubiquitin peptidase 1
  zinc finger imprinted 2
  zinc finger MIZ-type containing 1
  zinc finger MYND-type containing 8
  zinc finger protein 114
  zinc finger protein 197
  zinc finger protein 211
  zinc finger protein 250
  zinc finger protein 256
  zinc finger protein 267
  zinc finger protein 268
  zinc finger protein 273
  zinc finger protein 274
  zinc finger protein 30
  zinc finger protein 320
  zinc finger protein 324B
  zinc finger protein 326
  zinc finger protein 331
  zinc finger protein 333
  zinc finger protein 350
  zinc finger protein 354C
  zinc finger protein 382
  zinc finger protein 416
  zinc finger protein 420
  zinc finger protein 445
  zinc finger protein 460
  zinc finger protein 462
  zinc finger protein 471
  zinc finger protein 496
  zinc finger protein 517
  zinc finger protein 573
  zinc finger protein 585B
  zinc finger protein 595
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger protein 616
  zinc finger protein 620
  zinc finger protein 621
  zinc finger protein 622
  zinc finger protein 624
  zinc finger protein 658
  zinc finger protein 669
  zinc finger protein 689
  zinc finger protein 695
  zinc finger protein 701
  zinc finger protein 707
  zinc finger protein 720
  zinc finger protein 721
  zinc finger protein 732
  zinc finger protein 738
  zinc finger protein 746
  zinc finger protein 747
  zinc finger protein 764
  zinc finger protein 766
  zinc finger protein 77
  zinc finger protein 785
  zinc finger protein 829
  zinc finger protein 845
  zinc finger protein 93
  zinc finger RNA binding protein
  ZW10 interacting kinetochore protein

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