GSK3B, glycogen synthase kinase 3 beta

GSK3B, glycogen synthase kinase 3 beta

• The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]

• Gene Synonyms (glycogen synthase kinase-3 beta, GSK-3 beta, GSK3beta isoform, serine/threonine-protein kinase GSK3B,)
• NCBI Gene ID: 2932
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P49841
  UNIPROT ID#>>Q6FI27
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glycogen synthase kinase 3 beta interacts with:

• 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
  actin like 6B
  acyl-CoA synthetase bubblegum family member 1
  adipogenesis regulatory factor
  A-kinase anchoring protein 11
  AKT serine/threonine kinase 3
  ALMS1 centrosome and basal body associated protein
  aminoacyl tRNA synthetase complex interacting multifunctional protein 1
  aminopeptidase puromycin sensitive
  ankyrin repeat domain 6
  apoptosis resistant E3 ubiquitin protein ligase 1
  ArfGAP with dual PH domains 1
  arginyl aminopeptidase
  arginyl-tRNA synthetase 1
  asparaginase and isoaspartyl peptidase 1
  ataxin 3
  ATP binding cassette subfamily E member 1
  ATP synthase inhibitory factor subunit 1
  aurora kinase A
  autophagy related 2B
  axin 1
  axin 1
  axin 2
  BAG cochaperone 6
  BAR/IMD domain containing adaptor protein 2 like 1
  basic helix-loop-helix family member e41
  basic leucine zipper and W2 domains 2
  beta-transducin repeat containing E3 ubiquitin protein ligase
  BICD cargo adaptor 2
  biogenesis of ribosomes BRX1
  brain expressed X-linked 1
  calcium binding tyrosine phosphorylation regulated
  calmodulin regulated spectrin associated protein family member 3
  cAMP responsive element binding protein 3 like 3
  catenin (cadherin associated protein), beta 1
  CCAAT enhancer binding protein zeta
  CD274 molecule
  cell adhesion molecule 1
  cell cycle associated protein 1
  cell division cycle 37, HSP90 cochaperone
  centriolar coiled-coil protein 110
  centrosomal protein 131
  centrosomal protein 152
  centrosomal protein 350
  centrosomal protein 43
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  claspin
  class II major histocompatibility complex transactivator
  coiled-coil domain containing 138
  coiled-coil domain containing 6
  cold shock domain containing E1
  COP9 signalosome subunit 5
  COPI coat complex subunit beta 2
  COPI coat complex subunit gamma 1
  copine 3
  crystallin beta-gamma domain containing 3
  C-type lectin domain family 3 member B
  cyclase associated actin cytoskeleton regulatory protein 1
  cyclin dependent kinase 5 regulatory subunit 1
  cysteine sulfinic acid decarboxylase
  cytoplasmic linker associated protein 2
  DEAD-box helicase 20
  DEAF1 transcription factor
  DEAF1, transcription factor
  DEAH-box helicase 36
  decapping mRNA 1A
  decapping mRNA 1B
  DExH-box helicase 34
  dickkopf WNT signaling pathway inhibitor 3
  dipeptidyl peptidase 3
  DISC1 scaffold protein
  discs large MAGUK scaffold protein 5
  dishevelled segment polarity protein 1
  DNA damage inducible transcript 4
  DNA methyltransferase 3 like
  DNA polymerase delta interacting protein 2
  DNA topoisomerase II alpha
  DnaJ heat shock protein family (Hsp40) member C13
  dynactin subunit 2
  dynactin subunit 3
  dynamin 1 like
  dynein light chain LC8-type 1
  ecdysoneless cell cycle regulator
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  endoplasmic reticulum aminopeptidase 1
  endosome associated trafficking regulator 1
  enhancer of mRNA decapping 3
  EPM2A glucan phosphatase, laforin
  erbb2 interacting protein
  ergosterol biosynthesis 28 homolog
  erythrocyte membrane protein band 4.1 like 3
  eukaryotic translation initiation factor 2B subunit epsilon
  eukaryotic translation initiation factor 3 subunit B
  eukaryotic translation initiation factor 3 subunit C
  exportin 1
  exportin 6
  FA core complex associated protein 20
  family with sequence similarity 193 member B
  family with sequence similarity 83 member D
  far upstream element binding protein 1
  F-box and WD repeat domain containing 11
  F-box and WD repeat domain containing 7
  F-box protein 7
  FGF1 intracellular binding protein
  fibrillin 3
  FKBP prolyl isomerase 14
  FMR1 autosomal homolog 1
  FRAT regulator of WNT signaling pathway 1
  FRAT regulator of WNT signaling pathway 2
  frizzled class receptor 1
  frizzled class receptor 5
  gelsolin
  gem nuclear organelle associated protein 4
  GID complex subunit 8 homolog
  GIPC PDZ domain containing family member 1
  glucosidase II alpha subunit
  glutaminyl-tRNA synthetase 1
  glycogen phosphorylase L
  glycogen synthase 1
  glycogen synthase kinase 3 beta
  GSK3B interacting protein
  guanine monophosphate synthase
  HAUS augmin like complex subunit 4
  HAUS augmin like complex subunit 5
  HCLS1 associated protein X-1
  heat shock protein 90 alpha family class A member 1
  heat shock protein 90 alpha family class B member 1
  heat shock protein 90 beta family member 1
  heat shock protein family A (Hsp70) member 1A
  heat shock protein family A (Hsp70) member 4
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 8
  heat shock protein family A (Hsp70) member 9
  heat shock protein family D (Hsp60) member 1
  heat shock protein family H (Hsp110) member 1
  heat shock transcription factor 1
  HECT domain E3 ubiquitin protein ligase 1
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  heme oxygenase 2
  heterogeneous nuclear ribonucleoprotein A2/B1
  heterogeneous nuclear ribonucleoprotein D
  heterogeneous nuclear ribonucleoprotein K
  heterogeneous nuclear ribonucleoprotein M
  heterogeneous nuclear ribonucleoprotein U
  hexokinase 1
  histocompatibility 2, class II antigen A, alpha
  histone deacetylase 4
  histone deacetylase 6
  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
  hydroxysteroid 17-beta dehydrogenase 4
  ILK associated serine/threonine phosphatase
  immunoglobin superfamily member 21
  importin 5
  importin 7
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  inosine monophosphate dehydrogenase 2
  insulin like growth factor 2 mRNA binding protein 1
  insulin like growth factor 2 mRNA binding protein 3
  insulin receptor substrate 1
  integrin linked kinase
  integrin subunit beta 1
  intelectin 1
  interferon regulatory factor 1
  IQ motif containing G
  IQ motif containing GTPase activating protein 1
  isoleucyl-tRNA synthetase 2, mitochondrial
  Jun proto-oncogene, AP-1 transcription factor subunit
  karyopherin subunit beta 1
  KH-type splicing regulatory protein
  KIAA1191
  kinase D interacting substrate 220
  kinesin family member 5B
  KN motif and ankyrin repeat domains 2
  KRAB-A domain containing 1
  KRAB-A domain containing 1
  Kruppel like factor 2
  La ribonucleoprotein 1B
  lactate dehydrogenase B
  lamin A/C
  lamin B1
  LDL receptor related protein 6
  lectin, mannose binding 2
  leucine rich repeat containing 49
  leucine rich repeat containing 59
  leucine zipper, putative tumor suppressor 2
  leukotriene A4 hydrolase
  LIM domain only 4
  limb development membrane protein 1 like
  LTV1 ribosome biogenesis factor
  LUC7 like 2, pre-mRNA splicing factor
  lysine demethylase 1A
  lysophosphatidylcholine acyltransferase 1
  major vault protein
  malate dehydrogenase 1
  malate dehydrogenase 2
  mannan binding lectin serine peptidase 1
  mannosyl-oligosaccharide glucosidase
  MAP7 domain containing 3
  MCL1 apoptosis regulator, BCL2 family member
  MDM2 proto-oncogene
  mediator complex subunit 24
  melanocyte inducing transcription factor
  membrane palmitoylated protein 1
  MET proto-oncogene, receptor tyrosine kinase
  metal response element binding transcription factor 2
  methionyl-tRNA synthetase 1
  methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
  microtubule actin crosslinking factor 1
  microtubule associated monooxygenase, calponin and LIM domain containing 1
  microtubule associated protein 1B
  microtubule associated protein 4
  microtubule associated protein tau
  MID1 interacting protein 1
  minichromosome maintenance complex component 3
  minichromosome maintenance complex component 6
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase kinase 7
  mitogen-activated protein kinase kinase kinase 1
  mitogen-activated protein kinase kinase kinase 11
  mitogen-activated protein kinase kinase kinase 11
  mitogen-activated protein kinase kinase kinase 2
  mitogen-activated protein kinase kinase kinase 4
  moesin
  mucin 1, cell surface associated
  MYC associated zinc finger protein
  MYC proto-oncogene, bHLH transcription factor
  myocardin
  myocardin related transcription factor A
  myoferlin
  myosin heavy chain 9
  myosin IB
  N-acetyltransferase 9 (putative)
  NADH:ubiquinone oxidoreductase core subunit S1
  NADH:ubiquinone oxidoreductase subunit A9
  nascent polypeptide associated complex subunit alpha
  NBR1 autophagy cargo receptor
  NBR1, autophagy cargo receptor
  negative regulator of ubiquitin like proteins 1
  niban apoptosis regulator 2
  ninein
  NLR family pyrin domain containing 2
  N-myc downstream regulated 1
  non-POU domain containing octamer binding
  non-POU-domain-containing, octamer binding protein
  NOP2/Sun RNA methyltransferase 2
  notch receptor 1
  notch receptor 2
  notch receptor 3
  NSFL1 cofactor
  nuclear factor kappa B subunit 1
  nuclear factor of activated T cells 1
  nuclear factor of activated T cells 2
  nuclear factor, erythroid 2 like 1
  nuclear factor, erythroid 2 like 2
  nuclear factor, erythroid 2 like 3
  nuclear FMR1 interacting protein 1
  nuclear receptor binding protein 1
  nuclear receptor coactivator 3
  nucleolin
  nucleoporin 205
  nucleosome assembly protein 1 like 1
  OFD1 centriole and centriolar satellite protein
  O-GlcNAcase
  O-linked N-acetylglucosamine (GlcNAc) transferase
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  p21 (RAC1) activated kinase 2
  paxillin
  PDZ and LIM domain 1
  peroxisomal biogenesis factor 5
  PH domain and leucine rich repeat protein phosphatase 1
  phenylalanyl-tRNA synthetase subunit beta
  phorbol-12-myristate-13-acetate-induced protein 1
  phosphodiesterase 4D
  phosphoglycerate dehydrogenase
  Pim-2 proto-oncogene, serine/threonine kinase
  pleckstrin homology domain containing A4
  pleiotrophin
  poly(A) binding protein cytoplasmic 1
  poly(ADP-ribose) polymerase family member 10
  poly(ADP-ribose) polymerase family member 3
  polypyrimidine tract binding protein 1
  PPARG coactivator 1 alpha
  predicted gene 4779
  presenilin 1
  programmed cell death 6 interacting protein
  proline rich coiled-coil 2C
  prolyl 4-hydroxylase subunit beta
  prospero homeobox 2
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 2
  proteasome activator subunit 3
  protein disulfide isomerase family A member 4
  protein inhibitor of activated STAT 1
  protein kinase C alpha
  protein kinase C and casein kinase substrate in neurons 2
  protein kinase C beta
  protein kinase C delta
  protein kinase C substrate 80K-H
  protein kinase C zeta
  protein kinase cAMP-activated catalytic subunit alpha
  protein kinase cAMP-activated catalytic subunit beta
  protein kinase cAMP-dependent type I regulatory subunit alpha
  protein kinase cAMP-dependent type I regulatory subunit beta
  protein kinase cAMP-dependent type II regulatory subunit alpha
  protein kinase, DNA-activated, catalytic subunit
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 1 catalytic subunit beta
  protein phosphatase 1 catalytic subunit gamma
  protein phosphatase 1 regulatory inhibitor subunit 2
  protein phosphatase 2 catalytic subunit alpha
  protein phosphatase 2 regulatory subunit B'delta
  protein phosphatase 3 catalytic subunit alpha
  protein phosphatase 3 catalytic subunit gamma
  protein phosphatase 6 regulatory subunit 1
  protein phosphatase 6 regulatory subunit 3
  protein regulator of cytokinesis 1
  protein tyrosine kinase 2
  protein tyrosine phosphatase non-receptor type 1
  protein tyrosine phosphatase non-receptor type 11
  prune exopolyphosphatase
  prune exopolyphosphatase 1
  pyridoxal kinase
  pyruvate kinase M1/2
  Ras association domain family member 1
  Ras suppressor protein 1
  recombination signal binding protein for immunoglobulin kappa J region
  RecQ like helicase 4
  regulation of nuclear pre-mRNA domain containing 1B
  regulator of calcineurin 2
  regulator of chromosome condensation 2
  RELA proto-oncogene, NF-kB subunit
  RELB proto-oncogene, NF-kB subunit
  replication protein A1
  retinoic acid induced 1
  retinoid X receptor alpha
  Rho guanine nucleotide exchange factor (GEF) 11
  Rho guanine nucleotide exchange factor 11
  ribonucleotide reductase catalytic subunit M1
  ribosomal protein L36a like
  ribosomal protein L39
  ribosomal protein L6
  ribosomal protein lateral stalk subunit P0
  ribosomal protein lateral stalk subunit P1
  ribosomal protein S2
  ribosomal protein S6 kinase A1
  ribosome production factor 2 homolog
  ring finger protein 220
  RNA binding motif protein 33
  RPTOR independent companion of MTOR complex 2
  SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
  SAP30 binding protein
  SEC16 homolog A, endoplasmic reticulum export factor
  septin 9
  serine/threonine kinase 11
  serine/threonine kinase receptor associated protein
  serum/glucocorticoid regulated kinase 1
  serum/glucocorticoid regulated kinase family member 3
  SET and MYND domain containing 2
  SET nuclear proto-oncogene
  signal recognition particle 72
  signal sequence receptor subunit 1
  SMAD family member 1
  SMAD family member 3
  SMAD specific E3 ubiquitin protein ligase 2
  small nuclear ribonucleoprotein U1 subunit 70
  snail family transcriptional repressor 1
  snail family transcriptional repressor 2
  solute carrier family 25 member 13
  solute carrier family 3 member 2
  Sp1 transcription factor
  Sp7 transcription factor
  spectrin beta, non-erythrocytic 4
  spectrin repeat containing nuclear envelope family member 4
  sperm associated antigen 5
  spindle and centriole associated protein 1
  spindle and centriole associated protein 1
  splicing factor 3b subunit 1
  splicing factor proline and glutamine rich
  Src like adaptor
  SRY-box transcription factor 10
  SRY-box transcription factor 9
  staphylococcal nuclease and tudor domain containing 1
  sterol regulatory element binding transcription factor 1
  stonin 1
  structure specific recognition protein 1
  survival of motor neuron 2, centromeric
  switching B cell complex subunit SWAP70
  synuclein alpha
  synuclein alpha interacting protein
  tafazzin
  TANK binding kinase 1
  t-complex 1
  testis specific serine kinase substrate
  thioredoxin reductase 1
  thymopoietin
  tight junction protein 1
  TLE family member 1, transcriptional corepressor
  TNF receptor associated factor 2
  TNF receptor associated factor 6
  TNF receptor associated protein 1
  tonsoku like, DNA repair protein
  TRAF family member associated NFKB activator
  trafficking kinesin protein 1
  trafficking kinesin protein 2
  transferrin receptor
  transmembrane protein 132A
  transmembrane protein 44
  tripartite motif containing 25
  tripartite motif containing 28
  TSC complex subunit 1
  TSC complex subunit 2
  tubulin alpha 1a
  tubulin alpha 1b
  tubulin polyglutamylase complex subunit 1
  tubulin polymerization promoting protein
  tubulin tyrosine ligase like 12
  tumor protein p53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  tyrosyl-tRNA synthetase 1
  U2 small nuclear RNA auxiliary factor 1
  ubiquitin C
  ubiquitin conjugating enzyme E2 D1
  ubiquitin fold modifier 1
  ubiquitin like modifier activating enzyme 1
  ubiquitin protein ligase E3 component n-recognin 1
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 48
  UBX domain protein 2B
  UBX domain protein 6
  UDP-glucose 6-dehydrogenase
  UPF3A regulator of nonsense mediated mRNA decay
  vacuolar protein sorting 13 homolog D
  valosin containing protein
  vesicle (multivesicular body) trafficking 1
  vesicle trafficking 1
  vimentin
  vinculin
  VPS35 retromer complex component
  WD repeat and SOCS box containing 1
  WD repeat domain 62
  X-prolyl aminopeptidase 1
  Y-box binding protein 1
  Y-box binding protein 3
  Yes1 associated transcriptional regulator
  zinc finger protein 135
  zinc finger protein 227
  zinc finger protein 281
  zinc finger protein 746
  zinc finger protein, FOG family member 1
  zinc finger, BED type containing 3
  zinc fingers and homeoboxes 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.